IP Library › Patent Application 11423605
Patent Application
App. No. 11/423,605

System, Method, and Computer Software Product for Gain Adjustment in Biological Microarray Scanner

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Quick Facts
Patent No.
US None
App. No.
11/423,605
Abstract

In accordance with some embodiments of the present invention, a method for gain adjustment is described that comprises (a) receiving a user selection of one or more parameters that includes a first resolution value; (b) obtaining a plurality of pixel intensity values using the user selected parameters and a gain value, wherein the obtained pixel intensity values are representative of a distribution of pixel intensity values; (c) generating a measure of comparison between the representative distribution and a desired distribution of pixel intensity values; (d) adjusting the gain value using the measure of comparison; and (e) obtaining a plurality of pixel intensity values using a second resolution value and the adjusted gain value.

Claims (43)

1 . A method for gain adjustment, comprising:

(a) receiving a user selection of one or more parameters that includes a first resolution value;

(b) obtaining a plurality of pixel intensity values using the user selected parameters and a gain value, wherein the obtained pixel intensity values are representative of a distribution of pixel intensity values;

(c) generating a measure of comparison between the representative distribution and a desired distribution of pixel intensity values;

(d) adjusting the gain value using the measure of comparison; and

(e) obtaining a plurality of pixel intensity values using a second resolution value and the adjusted gain value.

2 . The method of claim 1 , wherein:

the first resolution value includes a measure of resolution that is less than the second resolution value.

3 . The method of claim 1 , wherein:

the first resolution value is indicative of an average value of two or more pixels.

4 . The method of claim 1 , wherein:

the first resolution value is indicative of obtaining values from non-neighboring pixels, wherein one or more pixels are positioned between each pixel value obtained.

5 . The method of claim 1 , wherein:

the first resolution value is indicative of obtaining lines of pixel values from non-neighboring lines of pixels, wherein one or more lines of pixels are positioned between each line of pixel values obtained.

6 . The method of claim 1 , wherein:

the parameters include one or more values associated with a scan area.

7 . The method of claim 6 , wherein:

the values associated with a scan area comprise a value associated with the X axis and a value associated with the Y axis.

8 . The method of claim 7 , wherein:

the value associated with the X axis includes a measure of distance from a first point of reference, and the value associated with the Y axis includes a measure of distance from a first point of reference.

9 . The method of claim 1 , further comprising:

repeating steps (b)-(d) using the adjusted gain value at each iteration until an acceptable gain value is determined; and

obtaining a plurality of pixel intensity values using a second resolution value and the acceptable gain value.

10 . A system for gain adjustment, comprising:

a gain data manager that receives a user selection of one or more parameters that includes a first resolution value;

an intensity manager that obtains a plurality of pixel intensity values using the user selected parameters and a gain value, wherein the obtained pixel intensity values are representative of a distribution of pixel intensity values;

a comparison manager that generates a measure of comparison between the representative distribution and a desired distribution of pixel intensity values;

a gain adjuster that adjusts the gain value using the measure of comparison; and

a controller that obtains a plurality of pixel intensity values using a second resolution value and the adjusted gain value.

11 . The system of claim 10 , wherein:

the first resolution value includes a measure of resolution that is less than the second resolution value.

12 . The system of claim 10 , wherein:

the first resolution value is indicative of an average value of two or more pixels.

13 . The system of claim 10 , wherein:

the first resolution value is indicative of obtaining values from non-neighboring pixels, wherein one or more pixels are positioned between each pixel value obtained.

14 . The system of claim 10 , wherein:

the first resolution value is indicative of obtaining lines of pixel values from non-neighboring lines of pixels, wherein one or more lines of pixels are positioned between each line of pixel values obtained.

15 . The method of claim 10 , wherein:

the parameters include one or more values associated with a scan area.

16 . The method of claim 15 , wherein:

the values associated with a scan area comprise a value associated with the X axis and a value associated with the Y axis.

17 . The method of claim 16 , wherein:

the value associated with the X axis includes a measure of distance from a first point of reference, and the value associated with the Y axis includes a measure of distance from a first point of reference.