Hat for treating a tumor or the like
View Patent ↗An article of clothing is pro-vided for selectively destroying dividing cells in living tissue formed of dividing cells and non-dividing cells. The dividing cells contain polarizable intracellular members and during late anaphase or telophase, the dividing cells are connected to one another by a cleavage furrow. The article of clothing includes insulated electrodes to be coupled to a generator for subjecting the living tissue to electric field conditions sufficient to cause movement of the polarizable intracellular members toward the cleavage furrow in response to a non-homogeneous electric field being induced in the dividing cells. The non-homogeneous electric field produces an increased density electric field in the region of the cleavage furrow. The movement of the polarizable intracellular intracellular members towards the cleavage furrow causes the breakdown thereof which adversely impacts the multiplication of the dividing cells.
1. A hat for treatment of an intra-cranial tumor or lesion by selectively destroying dividing cells of the tumor, the dividing cells having polarizable or polar or charged intracellular members, the hat comprising: a hat body to be worn over a head and including a predetermined number of openings formed therein; at least one insulated electrode unit for placement in one of the openings of the hat, each unit being a member having an insulated electrode disposed at one face thereof and a biasing mechanism for applying a biasing force against the insulated electrode in a direction away from the hat body, the insulated electrode being disposed at one face of the hat body when the unit is inserted and securely held within the opening; and an electric field source for applying an alternating electric potential across at least two insulated electrodes to create an electric field in the dividing cells, wherein passage of the electric field through the dividing cells in late anaphase or telophase transforms the electric field into a non-homogenous electric field that produces an increased density electric field in a region of a cleavage furrow of the dividing cells, wherein the non-homogeneous electric field produced within the dividing cells has amplitude and frequency characteristics such that long-term application of the electric field causes the destruction of cells as they divide, but wherein the electric field is sufficiently small so that during long-term application of the electric field, the destruction of the dividing cells is not caused by heat.
2. The hat of claim 1 , wherein the unit includes a first electric connector for attachment to a conductor which is coupled at its opposite end to the electric field source.
3. The hat of claim 1 , wherein the unit is securely retained within the opening by an adhesive member that has an adhesive layer formed on at least one side thereof, the adhesive member being disposed around a peripheral edge of the insulated electrode and over a peripheral edge of the hat body around the opening for securely positioning and retaining the unit within the opening with the insulated electrode being positioned at one face of the hat body.
4. The hat of claim 1 , wherein the alternating electric potential has a frequency of between about 50 KHz to about 500 KHz.
5. The hat of claim 1 , wherein the electric field source comprises a generator that generates an alternating voltage waveform at frequencies between about 50 KHz to about 500 KHz that activate each insulated electrode.
6. The hat of claim 5 , wherein the generator is disposed within the hat body.
7. The hat of claim 1 , wherein the biasing mechanism includes a spring that applies a biasing force against one of the first and second electrodes in the direction toward the living tissue.
8. The hat of claim 7 , wherein the biasing mechanism is contained within a unit that is detachably coupled to the hat to permit removal and replacement thereof.
9. The hat of claim 1 , wherein the biasing mechanism comprises a body formed of an elastic material that is disposed within the article of clothing in close proximity to or in contact with one of the insulated electrodes.
10. The hat of claim 1 , wherein each insulated electrode includes a conductor and a dielectric member in contact therewith and for placement against the head to form a capacitor.
11. The hat of claim 10 , wherein the insulated electrode includes an intervening filler disposed on the respective dielectric member thereof, the intervening filler being formed of a material that has high conductance and a high dielectric constant.
12. The hat of claim 11 , wherein the intervening filler comprises a gel formed of at least one material selected from the group consisting of gelatins and agar.
13. The hat of claim 1 , wherein the at least one insulated electrode unit is removably disposed within one of the openings of the hat.
14. The hat of claim 1 , wherein the insulated electrode is free from a planar shape and is shaped to have a contour complementary to a skin surface of the head.
15. The hat of claim 1 , wherein the alternating electric potential has a frequency of between about 100 KHz to about 300 KHz.
16. The hat of claim 1 , wherein the electric field source comprises a generator that generates an alternating voltage waveform at frequencies between about 100 KHz to about 300 KHz that activate each insulated electrode.