Process for milling and preparing powders and compositions produced thereby
View Patent ↗A method of milling a powder comprising introducing a gas stream containing a cryogenic liquid and a drug carrier gas into a jet mill, and milling a powder with the jet mill in one or more milling passes. A product produced by the method. A milling apparatus comprising a cryogenic gas input system, a powder feeder, a main jet-mill, and at least one output port for collecting the powder.
1. A method of milling a powder, comprising:
introducing a powder to be milled into a jet mill impact chamber,
introducing a cold stream comprising a mixture of cryogenic liquid and a carrier gas into the jet mill impact chamber; and
milling the powder in the impact chamber of said jet mill in one or more milling passes.
2. The method of claim 1 , wherein the milling is a batch operation.
3. The method of claim 2 , wherein the one or more milling passes is/are done successively.
4. The method of claim 1 , wherein said cryogenic liquid comprises liquid nitrogen.
5. The method of claim 1 , wherein said powder comprises one or more disintegrants, dispersion agents, solubilizers, surfactants, sugars, salts, fatty acid permeation enhancers, or drugs.
6. The method of claim 1 , wherein said milling is performed in two or more successive milling passes.
7. The method of claim 1 , further comprising a shear mixing or grinding step of said powder.
8. The method of claim 1 , wherein said powder comprises particles having diameters ranging from about 100 nanometers to about 1 millimeter.
9. The method of claim 1 , wherein said milling occurs at a temperature of about 20 degrees Celsius or lower.
10. The method of claim 1 , wherein said milling occurs at a temperature of about −100 degrees Celsius to about 20 degrees Celsius.
11. A method of milling a powder, comprising:
introducing a powder to be milled comprising particles having a diameter ranging from about 100 nanometers to about 1 millimeter into a jet mill impact chamber;
introducing a cold stream comprising a mixture of liquid nitrogen and a nitrogen gas into the jet mill impact chamber; and
milling the powder in said jet mill impact chamber in two or more milling passes.
12. The method of claim 11 , wherein said milling is a batch operation.
13. The method of claim 12 , wherein said two or more milling passes are done successively.
14. A milling apparatus, comprising:
a cryogenic gas input system;
a powder feeder;
a main jet-mill comprising an impact chamber; and
at least one output port from said jet-mill for collecting said powder;
wherein said cryogenic gas input system comprises a cryogenic liquid input and a carrier gas input, wherein said cryogenic liquid input and said carrier gas input are in communication to provide a mixture of cryogenic liquid and a carrier gas prior to the introduction of said mixture into said main jet mill impact chamber.
15. The method of claim 1 , wherein said milling occurs at a temperature of about 0 degrees Celsius or lower.
16. The method of claim 1 , wherein said milling occurs at a temperature of about −100 degrees Celsius to about 0 degrees Celsius.
17. The method of claim 11 , wherein said milling occurs at a temperature of about 0 degrees Celsius or lower.
18. The method of claim 11 , wherein said milling occurs at a temperature of about −100 degrees Celsius to about 0 degrees Celsius.