Method of modulating stress-activated protein kinase system
View Patent ↗Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.
1. A compound selected from the group consisting of:
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or a pharmaceutically acceptable salt or ester thereof.
2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable excipient.
3. The pharmaceutical composition of claim 2 , wherein the composition contains an amount of said compound that is selected for administration to a patient on a schedule selected from: twice a day, once a day, once every two days, three times a week, twice a week, and once a week.
4. The pharmaceutical composition of claim 2 , wherein the composition consists of an amount of said compound that is selected for administration to a patient on a schedule selected from the group consisting of twice a day, once a day, once every two days, three times a week, twice a week, and once a week.
5. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
6. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
7. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
8. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
9. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
10. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
11. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
12. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
13. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
14. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
15. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
16. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
17. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
18. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.
19. The compound of claim 1 having a structure
or a pharmaceutically acceptable salt or ester thereof.