Gel compositions for control of ecto-parasites
View Patent ↗Semi-solid compositions comprising metaflumizone, a gelling agent and a non-aqueous solvent. The semi-solid compositions of this invention may be topically administered to animals, and are useful for preventing or treating, ectoparasitic infestations in warm-blooded animals for prolonged periods of time.
1. A composition for topical administration which comprises on a weight to weight basis
from about 5% to about 30% of metaflumizone;
from about 1% to about 15% of a gelling agent;
from about 0% to about 8% of a surfactant; and
from about 45% to about 80% of a non-aqueous solvent system.
2. The composition according to claim 1 which comprises from about 5% to about 20% of the metaflumizone compound.
3. The composition according to claim 1 , which comprises from about 2% to 15% of the gelling agent.
4. The composition according to claim 2 , which comprises from about 2% to 15% of the gelling agent.
5. The composition according to claim 1 wherein the gelling agent is selected from the group consisting of colloidal silicone dioxide, ethyl cellulose, methyl cellulose, methacrylic esters copolymers, carboxylated vinyl acetate terpolymer, PVP/Vinyl acetate copolymers or an equivalent non-aqueous solvent soluble polymer.
6. The composition according to claim 2 wherein the gelling agent is selected from the group consisting of colloidal silicone dioxide, ethyl cellulose, methyl cellulose, methacrylic esters copolymers, carboxylated vinyl acetate terpolymer, PVP/Vinyl acetate copolymers or an equivalent non-aqueous solvent soluble polymer.
7. The composition according to claim 1 wherein the surfactant is a non-ionic surfactant.
8. The composition according to claim 2 wherein the surfactant is a non-ionic surfactant.
9. The composition according to claim 1 wherein the surfactant is polyoxyothylene 20 sorbitan monooleate.
10. The composition according to claim 2 wherein the surfactant is polyoxyethylene 20 sorbitan monooleate.
11. The composition according to claim 1 wherein the amount of the surfactant is about 3% to about 5%.
12. The composition according to claim 2 wherein the amount of the surfactant is about 3% to about 5%.
13. The composition according to claim 1 wherein the solvent system comprises a mixture of approximately 7:1:2 ratio by weight of γ-hexalactone:N, N-diethyl-m-toluamide:propylene glycol dicaprylate/dicaprate.
14. The composition according to claim 2 wherein the solvent system comprises a mixture of approximately 7:1:2 ratio by weight of γ-hexalactone:N, N-diethyl-m-toluamide:propylene glycol dicaprylate/dicaprate.
15. The composition according to claim 1 which additionally contains up to about 8% by weight of one or more preservatives, colorants, antioxidants, or stabilizers.
16. The composition according to claim 1 which additionally includes an anti-syneresis agent.
17. A method for preventing or treating ectoparasitic infection or infestation in a warm-blooded animal which method comprises topically administering to the animal an ectoparasiticidally effective amount of a composition according to claim 1 .
18. A method for preventing or treating ectoparasitic infection or infestation in a warm-blooded animal which method comprises topically administering to the animal an ectoparasiticidally effective amount of a composition according to claim 2 .
19. The method according to claim 17 wherein the animal is selected from the group consisting of, a cow, a sheep, a horse, a camel, a deer, a swine, a goat, a dog, a cat, and a bird.
20. The method according to claim 18 wherein the animal is selected from the group consisting of a cow, a sheep, a horse, a camel, a deer, a swine, a goat, a dog, a cat, and a bird.