Versatile high load concentrate compositions for control of ecto- parasites
View Patent ↗High load concentrate compositions comprising metaflumizone, an optional bridging agent, a surfactant, and a suitable carrier solvent. These compositions may be topically administered to animals, and are useful for preventing or treating ectoparasitic infestations in warm-blooded animals for prolonged periods of time. Additionally, they may be further diluted to provide other types of formulations useable for both topical and oral administration.
1. A composition for topical administration which comprises on a weight to volume basis:
about 5% to about 25% of metaflumizone;
about 2% to about 15% of a surfactant selected from an alcohol alkoxylate surfactant, nonylphenol ethoxylate surfactant or polyoxyl 35 castor oil surfactant; and
about 50% to 80% of a carrier solvent.
2. The composition according to claim 1 , which comprises about 15% to 25% metaflumizone.
3. The composition according to claim 1 wherein the surfactant is an alcohol alkoxylate surfactant.
4. The composition according to claim 2 wherein the surfactant is a nonylphenol ethoxylate surfactant.
5. The composition according to claim 1 wherein the surfactant is present at a level of about 2% to about 8% w/v.
6. The composition according to claim 2 wherein the surfactant is present at a level of about 2% to about 8% w/v.
7. The composition according to claim 1 wherein the composition further comprises a bridging agent.
8. The composition according to claim 7 wherein the bridging agent is dimethyl sulfoxide.
9. The composition according to claim 1 wherein the carrier solvent is γ-hexylactone.
10. The composition according to claim 2 wherein the carrier solvent is γ-hexalactone.
11. The composition according to claim 1 wherein the carrier solvent is 1-methoxy-2-propyl acetate.
12. The composition according to claim 1 which additionally contains up to 2% of one or more preservatives, colorants, antioxidants, or stabilizers.
13. A method for preventing or treating ectoparasitic infection or infestation in a warm-blooded animal which method comprises topically administering to the animal effective amount of a composition according to claim 1 .
14. The method according to claim 13 wherein the animal is selected from the group consisting of a cow, a sheep, a horse, a camel, a deer, a swine, a goat, a dog, a cat, and a bird.
15. The method according to claim 13 wherein the composition comprises about 5% to about 25% metaflumizone; about 10% of a bridging agent; about 2% to about 8% surfactant; and about 50% to about 60% carrier solvent.
16. The method according to claim 13 wherein the composition comprises γ-hexylactone as the carrier solvent.
17. The method according to claim 13 wherein the composition is further diluted for use as a pour-on composition.
18. The method according to claim 16 wherein the composition further comprises 1-methoxy-2-propyl acetate.
19. The method according to claim 13 wherein the composition is further diluted for use as a spray or feed/water additive.
20. A method for preventing or treating ectoparasitic infection or infestation in a warm-blooded animal which method comprises topically administering to the animal an effective amount of a pour-on composition, comprising: the composition according to claim 1 ; and a diluent.