IP Library Patent Application 11438180
Patent Application
App. No. 11/438,180

Bio-inorganic conjugates

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Quick Facts
Patent No.
US None
App. No.
11/438,180
Abstract

A method for producing a bio-inorganic conjugate is provided comprising supplying a plurality of inorganic particles that are axially anisotropic; and positioning biomolecules intermediate the particles to form a chain-like structure. Also provided is an organized microscopic structure capable of vectorial electron transport within the structure, comprising a plurality of inorganic oxide particles, each particle having at least two ends; a first molecule covalently attached to each end to form a plurality of constructs; and a second molecule attached to the first molecule so as to link the constructs and form an elongated substrate.

Claims (30)

1 . A method for producing a bio-inorganic conjugate comprising:

c) supplying a plurality of inorganic particles that are axially anisotropic; and

b) positioning biomolecules intermediate the particles to form a predetermined-shape structure.

2 . The method as recited in claim 1 wherein each of the inorganic particles are elongate so as to define a longitudinal axis and at least two ends.

3 . The method as recited in claim 2 wherein each of the ends displays chemical activity specific for the biomolecules.

4 . The method as recited in claim 1 wherein the biomolecules are compounds selected from the group consisting of avidin, streptavidin, biotin, various biotin analogues such as iminobiotin, desthiobiotin, LC-biotin, and combinations thereof.

5 . The method as recited in claim 1 wherein steps a and b are repeated until the structure is approximately 1000 nanometers (nm) in length.

6 . The method as recited in claim 1 wherein the inorganic particles are oxides selected from the group consisting of TiO 2 , WO 3 , Fe 2 O 3 , ZrO 2 , SnO 2 , VO 2 , and combinations thereof.

7 . A bio-inorganic conjugate produced by the method recited in claim 1 .

8 . An organized microscopic structure capable of vectorial electron transport within the structure, comprising:

a) a plurality of inorganic oxide particles, each particle having at least two ends;

b) a first molecule covalently attached to each end to form a plurality of constructs; and

c) a second molecule attached to the first molecule so as to link the constructs and form an elongated substrate.

9 . The structure as recited in claim 8 wherein the ends are modified to facilitate attachment of the first molecules.

10 . The structure as recited in claim 8 having a length of between 500 nanometers and more than one micron.

11 . The structure as recited in claim 8 wherein a bidentate molecule is positioned intermediate the oxide particle and the first molecule.

12 . The structure as recited in claim 11 wherein the bidentate molecule is dopamine and wherein spacing between enediol groups of the dopamine match spacing of titanium atoms located at the ends.

13 . The structure as recited in claim 8 wherein the first molecule is biotin and the second molecule is avidin.

14 . A method for fabricating semiconductor particles, the method comprising:

a) supplying a semiconductor feedstock substrate shaped as a tube; and

b) subjecting the substrate to predetermined temperatures, pressures and pH for a time sufficient to produce single crystal particles emanating from surfaces of the tube, the particles defining at least a first termination point and a second termination point.

15 . The method as recited in claim 14 wherein the termination points define irregular crystal lattice structure.

16 . The method as recited in claim 14 wherein the substrate is comprised of TiO 2 .

17 . The method as recited in claim 14 wherein the particles define a geometric shape selected from the group consisting of rods, prisms, ellipses, spheres, stars, cubes, and pyramids.

18 . An electrical switch comprising:

a) a first inorganic semiconductor particle having a first end and a second end;

b) a complex of organic molecules attached to the first end and the second end to form an inorganic-organic construct having a first terminus and a second terminus; whereby the semiconductor induces a positive charge on the complex when the semiconductor is subjected to radiation; and

c) a second semiconductor particle attached to the first terminus, wherein the second semiconductor particle detaches from the first terminus when the semiconductor is subjected to radiation.

19 . The electrical switch as recited in claim 18 further comprising a third semiconductor particle attached to the second terminus.

20 . The electrical switch as recited in claim 18 whereby the semiconductor is a single crystal.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2006
From: UNIVERSITY OF CHICAGO, THE
To: U CHICAGO ARGONNE LLC
Reel/Frame 018385/0618 →
CONFIRMATORY LICENSE Recorded Sep 11, 2006
From: CHICAGO, THE UNIVERSITY OF
To: ENERGY, UNITED STATES DEPARTMENT
Reel/Frame 018289/0520 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2006
From: DIMITRIJEVIC, NADA; RAJH, TIJANA; SAPONJIC, ZORAN; RABATIC, BRYAN MILAN; TIEDE, DAVID M.; CHEN, LIN XIANG-QUN; ZAPOL, PETER
To: CHICAGO, UNIVERSITY OF, THE
Reel/Frame 018250/0294 →