Compounds, their preparation and use

1. A compound of the general formula (I):

wherein X 1 is aryl optionally substituted with one or more substituents selected from

halogen, hydroxy, cyano, amino or carboxy; or

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, aralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, C 1-6 -alkylthio, arylthio, C 3-6 -cycloalkylthio, C 1-6 -alkylcarbonyl, arylcarbonyl, C 1-6 -alkylsulfonyl, arylsulfonyl, C 1-6 -alkyl-sulfonyloxy, arylsulfonyloxy, C 1-6 -alkylamido, arylamido, C 1-6 -alkyl-aminocarbonyl, C 1-6 -alkylamino, C 1-6 -dialkylamino or C 3-6 -cycloalkylamino each of which is optionally substituted with one or more halogens; and

X 2 is arylene optionally substituted with one or more substituents selected from

halogen, hydroxy, cyano, amino or carboxy; or

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, C 1-6 -alkylthio, C 3-6 -cycloalkylthio, C 1-6 -alkylamino, C 1-6 -dialkylamino or C 3-6 -cycloalkylamino each of which is optionally substituted with one or more halogens; and

X 3 is aryl optionally substituted with one or more substituents selected from

halogen, hydroxy, cyano, amino or carboxy; or

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, C 1-6 -alkylthio, C 3-6 -cycloalkylthio, C 1-6 -alkylcarbonyl, C 1-6 -alkyl-sulfonyl, C 1-6 -alkylsulfonyloxy, C 1-6 -alkylamido, C 1-6 -alkylaminocarbonyl, C 1-6 -alkylamino, C 1-6 -dialkylamino or C 3-6 -cycloalkylamino each of which is optionally substituted with one or more halogens; and

Ar is arylene which is optionally substituted with one or more substituents selected from

halogen, hydroxy or cyano; or

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, aralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, C 1-6 -alkylthio, arylthio or C 3-6 -cycloalkylthio each of which is optionally substituted with one or more halogens; and

Y 1 is O or S; and

Y 2 is O or S; and

Z is —(CH 2 ) n — wherein n is 1, 2 or 3; and

R 1 is hydrogen, halogen or a substituent selected from

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aralkyl, heteroaralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, heteroaralkoxy, C 1-6 -alkylthio, arylthio or C 3-6 -cycloalkylthio each of which is optionally substituted with one or more halogens; and

R 2 is hydrogen, C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 4-6 -alkenynyl or aryl; or

a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, tautomeric form, stereoisomer, mixture of stereoisomers or racemic mixture thereof.

2. A compound according to claim 1 , wherein X 1 is aryl optionally substituted with one or more substituents selected from

halogen; or

C 1-6 -alkyl, aryl, C 1-6 -alkoxy, C 1-6 -alkylsulfonyl or C 1-6 -alkylsulfonyloxy each of which is optionally substituted with one or more halogens.

3. A compound according to claim 2 , wherein X 1 is phenyl optionally substituted with one or more substituents selected from

halogen; or

C 1-6 -alkyl, aryl, C 1-6 -alkoxy, C 1-6 -alkylsulfonyl or C 1-6 -alkylsulfonyloxy each of which is optionally substituted with one or more halogens.

4. A compound according to claim 3 , wherein X 1 is phenyl optionally substituted with one or more substituents selected from halogen, C 1-6 -alkyl, aryl or perhalomethyl.

5. A compound according to claim 4 , wherein X 1 is phenyl optionally substituted with one or more substituents selected from phenyl or trifluoromethyl.

6. A compound according to claim 5 , wherein X 1 is phenyl.

7. A compound according to claim 1 , wherein X 2 is arylene optionally substituted with one or more substituents selected from

halogen; or

C 1-6 -alkyl or C 1-6 -alkoxy each of which is optionally substituted with one or more halogens.

8. A compound according to claim 7 , wherein X 2 is phenylene optionally substituted with one or more substituents selected from

halogen; or

C 1-6 -alkyl or C 1-6 -alkoxy each of which is optionally substituted with one or more halogens.

9. A compound according to claim 8 , wherein X 2 is phenylene optionally substituted with one or more halogens.

10. A compound according to claim 9 , wherein X 2 is phenylene.

11. A compound according to claim 1 , wherein X 3 is aryl optionally substituted with one or more substituents selected from

halogen; or

C 1-6 -alkyl, C 1-6 -alkoxy, C 1-6 -alkylsulfonyl or C 1-6 -alkylsulfonyloxy each of which is optionally substituted with one or more halogens.

12. A compound according to claim 11 , wherein X 3 is phenyl optionally substituted with one or more substituents selected from

halogen; or

C 1-6 -alkyl, C 1-6 -alkoxy, C 1-6 -alkylsulfonyl or C 1-6 -alkylsulfonyloxy each of which is optionally substituted with one or more halogens.

13. A compound according to claim 12 , wherein X 3 is phenyl optionally substituted with one or more halogens.

14. A compound according to claim 12 , wherein X 3 is phenyl optionally substituted with one or more substituents selected from C 1-6 -alkyl or perhalomethyl.

15. A compound according to claim 12 , wherein X 3 is phenyl.

16. A compound according to claim 1 , wherein Ar is phenylene which is optionally substituted with one or more substituents selected from

halogen, hydroxy or cyano; or

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, aralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, C 1-6 -alkylthio, arylthio or C 3-6 -cycloalkylthio each of which is optionally substituted with one or more halogens.

17. A compound according to claim 16 , wherein Ar is phenylene which is optionally substituted with one or more substituents selected from

halogen; or

C 1-6 -alkyl, C 1-6 -alkoxy, aryloxy or aralkoxy each of which is optionally substituted with one or more halogens.

18. A compound according to claim 17 , wherein Ar is phenylene which is optionally substituted with methyl.

19. A compound according to claim 18 , wherein Ar is phenylene.

20. A compound according to claim 1 , wherein Y 1 is S.

21. A compound according to claim 1 , wherein Y 2 is O.

22. A compound according to claim 1 , wherein n is 1.

23. A compound according to claim 1 , wherein R 1 is hydrogen or a substituent selected from C 1-6 -alkyl, aralkyl, C 1-6 -alkoxy, aryloxy, aralkoxy each of which is optionally substituted with one or more halogens.

24. A compound according to claim 23 , wherein R 1 is hydrogen or a substituent selected from C 1-6 -alkyl or C 1-6 -alkoxy each of which is optionally substituted with one or more halogens.

25. A compound according to claim 24 , wherein R 1 is hydrogen.

26. A compound according to claim 1 , wherein R 2 is hydrogen.

27. A compound according to claim 1 , wherein R 2 is methyl or ethyl.

28. A compound according to claim 1 , which is selected from the following:

(E/Z) {4-[3-Biphenyl-4-yl-3-(4-bromo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid, and

(E/Z) {4-[3-(4-Bromo-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid; or

a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, tautomeric form, stereoisomer, mixture of stereoisomers, or racemic mixture thereof.

29. A compound according to claim 1 , which is selected from the following:

{4-[3-(4-Bromo-phenyl)-3-[1, 1′; 4′,1″]terphenyl-4″-yl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, tautomeric form, stereoisomer, mixture of stereoisomers or racemic mixture thereof.

30. A compound according to claim 1 , which is selected from the following:

(E) {4-[3-Biphenyl-4-yl-3-(2-fluoro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(2-fluoro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(2-chloro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(2-chloro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(2-bromo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(2-bromo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(2-iodo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(2-iodo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(2-methoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(2-methoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(2-trifluoromethoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(2-trifluoromethoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(2-methyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(2-methyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(2-trifluoromethyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(2-trifluoromethyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(3-fluoro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(3-fluoro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(3-chloro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(3-chloro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(3-bromo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(3-bromo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(3-iodo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(3-iodo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(3-methoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(3-methoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(3-trifluoromethoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(3-trifluoromethoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(3-methyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(3-methyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(3-trifluoromethyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(3-trifluoromethyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(4-fluoro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(4-fluoro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(4-chloro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(4-chloro-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E/Z) {4-[3-Biphenyl-4-yl-3-(4-bromo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(4-bromo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(4-bromo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(4-iodo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(4-iodo-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(4-methoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(4-methoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(4-trifluoromethoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(4-trifluoromethoxy-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(4-methyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(4-methyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-Biphenyl-4-yl-3-(4-trifluoromethyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(Z) {4-[3-Biphenyl-4-yl-3-(4-trifluoromethyl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid;

(E) {4-[3-(4-Fluoro-phenyl)-3-(2′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Fluoro-phenyl)-3-(2′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E/Z) {4-[3-(4-Fluoro-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Fluoro-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Fluoro-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Fluoro-phenyl)-3-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Fluoro-phenyl)-3-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Fluoro-phenyl)-3-(3′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Fluoro-phenyl)-3-(3′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Fluoro-phenyl)-3-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Fluoro-phenyl)-3-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Fluoro-phenyl)-3-(3′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Fluoro-phenyl)-3-(3′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Fluoro-phenyl)-3-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Fluoro-phenyl)-3-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Chloro-phenyl)-3-(2′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Chloro-phenyl)-3-(2′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E/Z) {4-[3-(4-Chloro-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Chloro-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Chloro-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Chloro-phenyl)-3-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Chloro-phenyl)-3-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Chloro-phenyl)-3-(3′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Chloro-phenyl)-3-(3′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Chloro-phenyl)-3-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Chloro-phenyl)-3-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Chloro-phenyl)-3-(3′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Chloro-phenyl)-3-(3′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Chloro-phenyl)-3-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Chloro-phenyl)-3-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Bromo-phenyl)-3-(2′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Bromo-phenyl)-3-(2′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E/Z) {4-[3-(4-Bromo-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Bromo-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Bromo-phenyl)-3-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Bromo-phenyl)-3-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Bromo-phenyl)-3-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Bromo-phenyl)-3-(3′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Bromo-phenyl)-3-(3′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Bromo-phenyl)-3-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Bromo-phenyl)-3-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Bromo-phenyl)-3-(3′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(Z) {4-[3-(4-Bromo-phenyl)-3-(3′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid;

(E) {4-[3-(4-Bromo-phenyl)-3-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid; and

(Z) {4-[3-(4-Bromo-phenyl)-3-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid; or

a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, tautomeric form, stereoisomer, mixture of stereoisomers or racemic mixture thereof.

31. A compound according to claim 1 , which is a PPARδ agonist.

32. A compound according to claim 31 , which is a selective PPARδ agonist.

33. A pharmaceutical composition comprising, as an active ingredient, at least one compound according to claim 1 , together with one or more pharmaceutically acceptable carriers or excipients.

34. A pharmaceutical composition according to claim 33 in unit dosage form, comprising from about 0.05 mg to about 1000 mg to about 200 mg per day of compound according to claim 1 .

35. A pharmaceutical composition according to any one of the claim 33 for oral, nasal, transdermal, pulmonal, or parenteral administration.