Iontophoresis device and method of controlling the same
An iontophoresis device, and a control method thereof, may be capable of increasing movement speed of a drug into a living body and/or may be capable of administering a drug having a high molecular weight. The iontophoresis device may include an active electrode assembly comprising: a first electrode; a drug holding part that receives a current from the first electrode; and a first ion exchange membrane that selectively passes ions of a first polarity, the first ion exchange membrane being placed on a front side of the drug holding part. Drug ions of the first polarity generated by the dissociation of a drug held in the drug holding part may be administered to a living body through the first ion exchange membrane in contact with skin of the living body. The iontophoresis device may include heating means to heat the skin in contact with the first ion exchange membrane.
1 . An iontophoresis device, comprising:
an active electrode assembly comprising:
a first electrode;
a drug holding part that holds a drug and to which an electrical potential of a first polarity is applied via the first electrode, drug ions of the first polarity being generated by dissociation of the drug held in the drug holding part; and
a first ion exchange membrane that selectively passes ions of the first polarity, the first ion exchange membrane being placed on a front side of the drug holding part, the drug ions of the first polarity being administered to a living body through the first ion exchange membrane in contact with skin of the living body; and
a heating means for heating the skin of the living body in contact with the first ion exchange membrane.
2 . An iontophoresis device according to claim 1 , wherein the heating means comprises a rubber heater.
3 . An iontophoresis device according to claim 1 , wherein the heating means comprises an infrared radiator.
4 . An iontophoresis device according to claim 1 , wherein the active electrode assembly further comprises:
a first electrolyte solution holding part that holds an electrolyte solution in contact with the first electrode; and
a second ion exchange membrane that selectively passes ions of a second polarity, the second ion exchange membrane being placed on a front side of the first electrolyte solution holding part,
wherein the drug holding part is placed on a front side of the second ion exchange membrane.
5 . An iontophoresis device according to claim 1 , further comprising a counter electrode assembly comprising:
a second electrode;
a second electrolyte solution holding part that holds an electrolyte solution in contact with the second electrode;
a third ion exchange membrane that selectively passes ions of the first polarity, the third ion exchange membrane being placed on a front side of the second electrolyte solution holding part;
a third electrolyte solution holding part that holds an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the third ion exchange membrane; and
a fourth ion exchange membrane that selectively passes ions of the second polarity, the fourth ion exchange membrane being placed on a front side of the third electrolyte solution holding part.
6 . A method of controlling an iontophoresis device, comprising:
a first electrode;
a drug holding part that holds a drug and to which an electrical potential of a first polarity is applied via the first electrode, drug ions of the first polarity being generated by dissociation of the drug held in the drug holding part; and
a first ion exchange membrane that selectively passes ions of the first polarity, the first ion exchange membrane being placed on a front side of the drug holding part, the drug ions of the first polarity being administered to a living body through the first ion exchange membrane in contact with skin of the living body; and
a heating means;
the method comprising applying a voltage of the first polarity to the first electrode while dissipating heat from the heating means to heat the skin of the living body in contact with the first ion exchange membrane.
7 . An iontophoresis device according to claim 2 wherein the active electrode assembly further comprises:
a first electrolyte solution holding part that holds an electrolyte solution in contact with the first electrode; and
a second ion exchange membrane that selectively passes ions of a second polarity, the second ion exchange membrane being placed on a front side of the first electrolyte solution holding part,
wherein the drug holding part is placed on a front side of the second ion exchange membrane.
8 . An iontophoresis device according to claim 2 further comprising a counter electrode assembly comprising:
a second electrode;
a second electrolyte solution holding part that holds an electrolyte solution in contact with the second electrode;
a third ion exchange membrane that selectively passes ions of the first polarity, the third ion exchange membrane being placed on a front side of the second electrolyte solution holding part;
a third electrolyte solution holding part that holds an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the third ion exchange membrane; and
a fourth ion exchange membrane that selectively passes ions of the second polarity, the fourth ion exchange membrane being placed on a front side of the third electrolyte solution holding part.
9 . An iontophoresis device according to claim 3 wherein the active electrode assembly further comprises:
a first electrolyte solution holding part that holds an electrolyte solution in contact with the first electrode; and
a second ion exchange membrane that selectively passes ions of a second polarity, the second ion exchange membrane being placed on a front side of the first electrolyte solution holding part,
wherein the drug holding part is placed on a front side of the second ion exchange membrane.
10 . An iontophoresis device according to claim 3 further comprising a counter electrode assembly comprising:
a second electrode;
a second electrolyte solution holding part that holds an electrolyte solution in contact with the second electrode;
a third ion exchange membrane that selectively passes ions of the first polarity, the third ion exchange membrane being placed on a front side of the second electrolyte solution holding part;
a third electrolyte solution holding part that holds an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the third ion exchange membrane; and
a fourth ion exchange membrane that selectively passes ions of the second polarity, the fourth ion exchange membrane being placed on a front side of the third electrolyte solution holding part.