Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same
Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
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10 . A method for the treatment of disorders of the urogenital region and cancer comprising administering to a patient in need thereof an effective amount of a compound of formula (I)
in which
n represents a number 2, 3 or 4,
R 1 represents hydrogen or (C 1 -C 4 )-alkyl
and
R 2 represents pyridyl or thiazolyl which for its part may be substituted by (C 1 -C 4 )-alkyl, halogen, amino, dimethylamino, acetylamino, guanidino, pyridylamino, thienyl, furyl, imidazolyl, pyridyl, morpholinyl, thiomorpholinyl, piperdinyl, piperazinyl, N—(C 1 -C 4 )-alkylpiperazinyl, pyrrolidinyl, oxazolyl, isoxazolyl, pyrimidinyl, pyrazinyl, optionally (C 1 -C 4 )-alkyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by halogen, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy,
or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
11 . A method for the treatment of inflammatory and neuroinflammatory disorders, neurodegenerative disorders and pain comprising administering to a patient in need thereof an effective amount of a compound of formula (I)
in which
n represents a number 2, 3 or 4,
R 1 represents hydrogen or (C 1 -C 4 )-alkyl
and
R 2 represents pyridyl or thiazolyl which for its part may be substituted by (C 1 -C 4 )-alkyl, halogen, amino, dimethylamino, acetylamino, guanidino, pyridylamino, thienyl, furyl, imidazolyl, pyridyl, morpholinyl, thiomorpholinyl, piperidinyl, piperazinyl, N—(C 1 -C 4 )-alkylpiperazinyl, pyrrolidinyl, oxazolyl, isoxazolyl, pyrimidinyl, pyrazinyl, optionally (C 1 -C 4 )-alkyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by halogen, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy,
or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
12 . The method of claim 10 , wherein the compound of formula (I) is characterized
n represents the number 2,
R 1 represents hydrogen, methyl or ethyl,
and
R 2 represents pyridyl or thiazolyl which for its part may be substituted by methyl, ethyl, fluorine, chlorine, amino, dimethylamino, acetylamino, guanidino, 2-pyridylamino, 4-pyridylamino, thienyl, pyridyl, morpholinyl, piperidinyl, optionally methyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by chlorine or methoxy,
or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
13 . The method of claim 10 , wherein the compound of formula (I) is characterized
n represents the number 2,
R 1 represents hydrogen or methyl
and
R 2 represents pyridyl or thiazolyl which for its part may be substituted by methyl, chlorine, amino, dimethylamino, acetylamino, guanidino, 2-pyridylamino, 4-pyridylamino, thienyl, pyridyl, morpholinyl, 2-methylthiazol-5-yl, phenyl, 4-chlorophenyl or 3,4,5-trimethoxyphenyl,
or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
14 . The method of claim 10 , wherein the compound of formula (I) has the following structure
or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
15 . The method of claim 11 , wherein the compound of formula (I) is characterized
n represents the number 2,
R 1 represents hydrogen, methyl or ethyl,
and
R 2 represents pyridyl or thiazolyl which for its part may be substituted by methyl, ethyl, fluorine, chlorine, amino, dimethylamino, acetylamino, guanidino, 2-pyridylamino, 4-pyridylamino, thienyl, pyridyl, morpholinyl, piperidinyl, optionally methyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by chlorine or methoxy,
or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
16 . The method of claim 11 , wherein the compound of formula (I) is characterized
n represents the number 2,
R 1 represents hydrogen or methyl
and
R 2 represents pyridyl or thiazolyl which for its part may be substituted by methyl, chlorine, amino, dimethylamino, acetylamino, guanidino, 2-pyridylamino, 4-pyridylamino, thienyl, pyridyl, morpholinyl, 2-methylthiazol-5-yl, phenyl, 4-chlorophenyl or 3,4,5-trimethoxyphenyl,
or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
17 . The method of claim 11 , wherein the compound of formula (I) has the following structure
or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.