Method for processing and treating a biological fluid with light
View Patent ↗Apparatus ( 10 ), systems and methods are disclosed for treating a biological fluid with light. A container ( 206 ) of biological fluid is introduced into a fluid treatment chamber ( 40 ) where it is contacted with light provided by one or more light sources ( 60, 70 ) in proximity to the fluid treatment chamber ( 40 ). A light sensing system ( 650 ) senses the intensity of illumination of the light. A radiometer ( 460 ) may be inserted into fluid treatment chamber ( 40 ) to calibrate the light sensing system ( 650 ). An electronic control system ( 600 ) utilizes an interface circuit board ( 606 ) to interface a computer circuit board ( 602 ) to a display panel ( 37 ), a user interface panel ( 39, 39 a ), a relay circuit board ( 640 ), light sensors 404 and various other sensors ( 649 ). A detector ( 385 ) senses agitating movement of a tray ( 90 ) that contains biological fluids. Methods include calibrating ( 781 - 785 ), sensing ( 770 - 773 ) and correcting ( 774 - 775 ) light intensity measurements, and determining the length of treatment ( 776 ) to reach a desired illumination dose. A radiometer ( 460 ) is equipped with a plurality of light sensors ( 469 ) disposed on both sides to measure light intensity in chamber ( 40 ) and to provide a reference for calibrating light sensing system ( 650 ).
1. A method of treating a biological fluid in an apparatus with a fluid treatment chamber for receiving a biological fluid, a light source with a plurality of lamps disposed either above or below said fluid treatment chamber to treat the biological fluid with light and a light sensing system with a plurality of light sensors, said method comprising the steps of:
sensing the amount of light emitted by said plurality of lamps with said plurality of light sensors;
developing a plurality of frequency signals from the plurality of light sensors, the frequency of each frequency signal from each of said plurality of light sensors related to the amount of light received by each light sensor;
providing said plurality of frequency signals to a first multiplexer;
multiplexing the plurality of frequency signals with said first multiplexer to provide a first multiplexed frequency signal; and
counting the plurality of frequency signals in said first multiplexed frequency signal with a first counter to provide a first counted output signal representative of the amount of light emitted by said plurality of lamps.
2. The method of claim 1 comprising the additional step of:
providing said plurality of frequency signals from said plurality of light sensors to a second multiplexer;
multiplexing the plurality of frequency signals with said second multiplexer to provide a second multiplexed frequency signal; and
counting the plurality of frequency signals in said second multiplexed frequency signal with a second counter to provide a second counted output signal also representative of the amount of light emitted by said plurality of lamps; and
comparing said first counted output signal with said second counted output signal to confirm the accuracy of said first and second counted output signals.
3. The method of claim 1 comprising the additional step of:
providing at least one test signal of a known frequency to said first multiplexer to enable said light sensing system to assess the counting accuracy of said first counter.
4. The method of claim 1 comprising the additional step of:
providing a power level input from a power source to said first multiplexer to provide information about noise that may be present in the power system.
5. The method of claim 1 wherein said light source consists of a plurality of lamps disposed in two arrays, with one array disposed above said fluid treatment chamber and another array disposed below said fluid treatment chamber.
6. The method of claim 5 comprising the additional step of:
providing said plurality of frequency signals from said plurality of light sensors to a second multiplexer;
multiplexing the plurality of frequency signals with said second multiplexer to provide a second multiplexed frequency signal; and
counting the plurality of frequency signals in said second multiplexed frequency signal with a second counter to provide a second counted output signal also representative of the amount of light emitted by said plurality of lamps; and
comparing said first counted output signal with said second counted output signal to confirm the accuracy of said first counted output signals.
7. The method of claim 5 comprising the additional step of:
providing at least one test signal of a known frequency to said first multiplexer to enable said light sensing system to assess the counting accuracy of said first counter.
8. The method of claim 5 comprising the additional step of:
providing a power level input from a power source to said first multiplexer to provide information about noise that may be present in the power system.