IP Library Granted Patent US 7,463,353
Granted Patent B2
US 7,463,353 · App. 11/444,241 · Granted Dec 9, 2008

Modular, micro-scale, optical array and biodetection system

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Quick Facts
Patent No.
US 7,463,353
App. No.
11/444,241
Granted
Dec 9, 2008
Kind
B2
Abstract

A modular, micro-scale, optical array and biodetection device for quantifying fluorescence intensities of a plurality of substantially separated, and dimensionally uniform elements of a bioarray that are located at known positions on a plain support includes a light guide that directs bioarray illumination light from a respective light source to opposing sides of the plain support. An optical module collecting light individually from the bioarray elements includes an optical member, a filter, and a sensor, such as a CCD chip. The optical member collects and transfers emitted light from the bioarray elements via the filter to the sensor. The filter transfers light from the elements having a predefined wavelength spectrum and blocks light outside the predefined wavelength spectrum. The sensor receives transferred light from the elements and produces a signal corresponding to respective elements of the bioarray.

Claims (19)

1. A modular, micro-scale, optical array and biodetection device for quantifying fluorescence intensities of a plurality of substantially separated, and dimensionally uniform elements of a bioarray, said bioarray elements located at known positions on a plain support comprising:

a light guide directing bioarray illumination light from a respective light source to opposing sides of the plain support;

an optical module collecting light individually from the bioarray elements; said optical module including an optical member, a filter, and a sensor;

said optical member collects and transfers emitted light from the bioarray elements via the filter to the sensor; said optical member including a micro-lens array and a fiber optic faceplate;

said micro-lens array focusing emitted light from the bioarray elements, said micro-lens array having consistent scale and dimensionality with the bioarray elements;

said filter transfers light from the elements having a predefined wavelength spectrum and blocks light outside the predefined wavelength spectrum; and said sensor receives transferred light from the elements and produces a signal corresponding to respective elements of the bioarray.

2. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said sensor is a charge-coupled-device (CCD) chip.

3. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said fiber optic faceplate has consistent scale and dimensionality with the bioarray elements, said fiber optic faceplate transferring emitted light from the bioarray elements.

4. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said filter is located below said optical member proximate to said bioarray.

5. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said filter is located above said optical member proximate to said sensor.

6. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said optical member proximate to said bioarray.

7. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said fiber optic faceplate is located proximate to said bioarray.

8. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said filter is located between said micro- lens array and said fiber optic faceplate.

9. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said filter is located proximate to said sensor above said micro-lens array and said fiber optic faceplate.

10. A modular, micro-scale, optical array and biodetection device as recited in claim 1 wherein said sensor includes a charge coupled device (CCD) chip.

11. A modular, micro-scale, optical array and biodetection device as recited in claim 1 includes a reaction chamber, said reaction chamber containing said bioarray elements.

12. A modular, micro-scale, optical array and biodetection device as recited in claim 11 includes a temperature control coupled to said reaction chamber.

13. A modular, micro-scale, optical array and biodetection device as recited in claim 12 wherein said temperature control coupled said reaction chamber for controlling temperature in a range between from +4° C. and +95° C.

14. A modular, micro-scale, optical array and biodetection device as recited in claim 11 wherein said reaction chamber includes at least two ports.

Assignments (3)
CONFIRMATORY LICENSE Recorded Oct 23, 2006
From: UNIVERSITY OF CHICAGO, THE
To: UNITED STATES DEPARTMENT OF ENERGY
Reel/Frame 018426/0387 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2006
From: UNIVERSITY OF CHICAGO, THE
To: U CHICAGO ARGONNE LLC
Reel/Frame 018385/0618 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 31, 2006
From: YERSHOV, GENNADIY M.
To: CHICAGO, THE UNIVERSITY OF
Reel/Frame 017947/0493 →