Substituted sulphonamide compound and uses thereof
View Patent ↗The present invention relates to compounds of the formula (I), wherein R 1 and R 2 are as defined in the description; to pharmaceutical formulations comprising these compounds, and to the use of the compounds for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, and/or CNS disorders, to achieve reduction of body weight and/or body weight gain.
1. A compound of the formula (I):
or a pharmaceutically acceptable salt thereof, wherein either:
R 1 is methoxy and R 2 is methyl; or
R 1 is methoxy and R 2 is hydroxymethyl; or
R 1 is hydroxyl and R 2 is methyl.
2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is methoxy and R 2 is methyl.
3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is methoxy and R 2 is hydroxymethyl.
4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is hydroxyl and R 2 is methyl.
5. A pharmaceutical formulation comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof as an active ingredient, in combination with a pharmaceutically acceptable diluent or carrier.
6. A method for treatment of obesity, comprising administering an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
7. A method for treatment of type II diabetes, comprising administering an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
8. A method of treating type II diabetes by reducing body weight or reducing body weight gain, comprising administering to a subject in need thereof an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
9. A method for modulating 5-HT 6 receptor activity, comprising administering to a subject in need thereof an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.