Botulinum toxin and the treatment of primary disorders of mood and affect
View Patent ↗The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and CNS disorders comprising the administration of a neurotoxin.
1. A method of treating sleep onset insomnia or sleep maintenance insomnia comprising the steps of:
a) identifying a subject with said sleep disorder; and
b) administering an effective amount of a composition comprising a botulinum toxin immunotype A and a pharmaceutically acceptable carrier to said subject thereby reducing at least one symptom of said sleep disorder.
2. The method of claim 1 , wherein the botulinum toxin is botulinum toxin type A from Hall strain Clostridium botulinum.
3. The method of claim 1 , wherein the composition is administered by injection.
4. The method of claim 3 , wherein the injection is multifocal.
5. The method of claim 3 , wherein the composition is administered to the forehead.
6. The method of claim 3 , wherein the composition is administered to the scalp.
7. The method of claim 3 , wherein the composition is administered to the neck.
8. The method of claim 1 , wherein there are at least two injection sites.
9. The method of claim 1 , wherein the composition is administered transdermally.
10. A method of treating sleep onset insomnia or sleep maintenance insomnia comprising the steps of:
a) identifying a subject with said sleep disorder;
b) administering to said subject a composition comprising a botulinum toxin immunotype A and a pharmaceutically acceptable carrier by injection.
11. The method of claim 10 , wherein said composition decreases choline acetyltransferase activity.
12. The method of claim 10 , wherein said composition decreases synthesis of acetylcholine.
13. The method of claim 10 , wherein said botulinum toxin immunotype A is of the Hall strain.
14. The method of claim 10 , wherein injection is transcutaneous, subcutaneous, transdermal, or intramuscular.
15. The method of claim 14 , wherein the injection is multifocal.
16. The method of claim 14 , wherein the composition is administered to the brow or forehead.
17. The method of claim 14 , wherein the composition is administered to the scalp.
18. The method of claim 14 , wherein the composition is administered to the neck.
19. The method of claim 10 , wherein the composition is administered transdermally.