Compositions and methods for inhibition of the JAK pathway
View Patent ↗The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
1. A compound selected from the group consisting of N2-(3-Aminosulfonyl-4-methylphenyl)-5-fluoro-N4-[4-(prop-2-ynyloxy)phenyl]-2,4-pyrimidinediamine and 5-Fluoro-N2-(4-methyl-3-propionylaminosulfonylphenyl)-N4-[4-(prop-2-ynyloxy)phenyl]-2,4-pyrimidinediamine.
2. A compound which is N2-(3-Aminosulfonyl-4-methylphenyl)-5-fluoro-N4-[4-(prop-2-ynyloxy)phenyl]-2,4-pyrimidinediamine.
3. A compound which is 5-Fluoro-N2-(4-methyl-3-propionylaminosulfonylphenyl)-N4-[4-(prop-2-ynyloxy)phenyl]-2,4-pyrimidinediamine.
4. A pharmaceutical composition comprising the compound of claim 1 and at least one pharmaceutically acceptable excipient, diluent, preservative, stabilizer, or mixtures thereof.
5. A pharmaceutical composition comprising the compound of claim 2 and at least one pharmaceutically acceptable excipient, diluent, preservative, stabilizer, or mixtures thereof.
6. A pharmaceutical composition comprising the compound of claim 3 and at least one pharmaceutically acceptable excipient, diluent, preservative, stabilizer, or mixtures.