Pyrimidine compounds
This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject in need thereof an effective amount of one or more compounds of formula (I). Each variable in this formula is defined in the specification.
1. A compound of formula (I):
wherein
X is —N(R a )—
is C 1 -C 10 alkylene or —C(O)—
L 2 is deleted or C 1 -C 10 alkylene;
L 3 is C 3 -C 20 cycloalkyl;
each of R 1 , R 2 , and R 3 , independently, is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, heteroaryl, halo, CN, OR c , COOR c , OC(O)R c , C(O)R c , C(O)NR c R d , or NR c R d ;
R 4 is H; and
R 5 is C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, heteroaryl, or C 1 -C 10 alkyl substituted with C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, or N(R e R f );
in which each of R a , R b , R c , R d , R e , and R f , independently, is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, heteroaryl, or —C(O)R; R being H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, or heteroaryl;
or a salt thereof.
2. The compound of claim 1 , wherein L 3 is cyclohexylene.
3. The compound of claim 1 , wherein R 5 is C 1 -C 10 alkyl substituted with N(R e R f ).
4. The compound of claim 3 , R 5 is
5. The compound of claim 1 , R 3 is C 3 -C 20 heterocycloalkyl substituted with C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, OR′, C(O)R′, COOR′, C(O)N(R′R″), SO 2 R′, or C(S)N(R′R″), in which each of R′and R″, independently, is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, or heteroaryl.
6. A compound, wherein the compound is
7. A compound, wherein the compound is
8. A compound of formula (I):
wherein
X is —N(R a )—;
L 1 is C 1 -C 10 alkylene, or —C(O)—;
L 2 is deleted or C 1 -C 10 alkylene;
L 3 is C 3 -C 20 cycloalkyl;
R 1 is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, aryl, heteroaryl, halo, CN, OR c , COOR c , OC(O)R c , C(O)R c , C(O)NR c R d , or NR c R d ;
each of R 2 and R 3 , independently, is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, heteroaryl, halo, CN, OR e , COOR e , OC(O)R e , C(O)R e , C(O)NR e R f , or NR e R f ;
R 4 is H; and
R 5 is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, or heteroaryl; or R 4 and R 5 together are C 1 -C 10 alkylene or C 1 -C 10 heteroalkylene;
in which each of R a , R b , R c , R d , R e , and R f , independently, is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, or heteroaryl;
or a salt thereof.