Choroid plexus device
View Patent ↗Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
1. A device comprising:
a semi-permeable component comprising a confluent tissue coating of choroid plexus epithelial cells cultured on a porous scaffold;
at least one structural component that is at least partially composed of porous bone that is in contact with and supports the semi-permeable component;
wherein the semi-permeable component either substantially surrounds the at least one structural component or the semi-permeable component is substantially surrounded by the at least one structural component;
wherein the device forms an internal cavity that is substantially surrounded by the semi-permeable component and the porous bone;
wherein the semi-permeable component has at least one characteristic of the choroid plexus epithelium that is different from the characteristics of the peripheral epithelium.
2. The device of claim 1 , wherein the at least one structural component at least partially forms the internal cavity.
3. The device of claim 1 , for implantation in a subject,
wherein the porous bone is autologous, allogeneic or xenogeneic with respect to the subject.
4. The device of claim 3 , wherein the subject is an animal.
5. The device of claim 4 , wherein the animal is selected from the group consisting of a domesticated animal, a farm animal, a marine animal, a sport animal, a wild animal, a research animal, a zoo animal, a bird, an amphibian, a reptile, a fish and a mammal.
6. The device of claim 5 , wherein the mammal is a human.
7. The device of claim 1 , wherein the porous bone is genetically engineered.
8. The device of claim 1 , wherein the porous bone binds one or more biologically active molecules.
9. The device of claim 1 , wherein the porous bone is selected from the group consisting of organic, anorganic, demineralized, freeze-dried, and artificial.
10. The device of claim 1 , wherein the porous bone is engineered to at least partially prevent restructuring when implanted in a subject.
11. The device of claim 1 , wherein the porous bone is designed to be at least partially restructured when implanted in a subject.
12. The device of claim 1 , for implantation in a subject, wherein the porous bone is immunogenic with respect to the subject.
13. The device of claim 1 , for implantation in a subject, wherein the porous bone is non-immunogenic with respect to the subject.
14. The device of claim 1 , for implantation in a subject, wherein the porous bone is recognized as self by the subject.
15. The device of claim 1 , wherein the porous bone is micromachined.
16. The device of claim 1 , wherein the semi-permeable component substantially surrounds the at least one structural component.
17. The device of claim 1 , wherein the semi-permeable component is substantially surrounded by the at least one structural component.
18. The device of claim 1 , wherein the porous bone of the at least one structural component further comprises living bone cells.