IP Library Granted Patent US 7,609,809
Granted Patent B2
US 7,609,809 · App. 11/459,143 · Granted Oct 27, 2009

System and method of generating contour structures using a dose volume histogram

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Quick Facts
Patent No.
US 7,609,809
App. No.
11/459,143
Granted
Oct 27, 2009
Kind
B2
Abstract

A system and method of defining a new region of interest for an existing region of interest using a dose volume histogram. The method includes the acts of generating a dose volume histogram of radiation dose for a pre-existing region of interest, selecting a subset of the dose volume histogram, and defining a new region of interest that corresponds to the selected subset of the dose volume histogram.

Claims (73)

1. A method of defining a new region of interest for an existing region of interest using a dose volume histogram, the method comprising using a computer to carry out the steps of:

generating a dose volume histogram of radiation dose for a pre-existing region of interest;

selecting a subset of the dose volume histogram; and

defining a new region of interest that corresponds to the selected subset of the dose volume histogram.

2. A method as set forth in claim 1 and further comprising displaying a region on an image that corresponds to the selected subset of the dose volume histogram.

3. A method as set forth in claim 1 wherein the radiation dose is a dose delivered in one or more previous treatments.

4. A method as set forth in claim 1 wherein the radiation dose is a planned dose to be delivered to the patient.

5. A method as set forth in claim 1 and further comprising generating a treatment plan for the patient and wherein the new region of interest is used to modify the treatment plan.

6. A method as set forth in claim 1 wherein the new region of interest is an updated version of the existing region of interest.

7. A method as set forth in claim 1 wherein the radiation dose is a combination of a planned radiation dose to be delivered to the patient and a radiation dose previously delivered to the patient.

8. A method as set forth in claim 1 wherein the image is a dose map of a portion of the patient.

9. A method as set forth in claim 1 and further comprising adapting a treatment plan for the patient based on the new region of interest.

10. A method of defining a new region of interest for an existing region of interest using a dose volume histogram, the method comprising using a computer to carry out the steps of:

generating a dose volume histogram of radiation dose for a pre-existing region of interest;

selecting a subset of the dose volume histogram; and

defining a new region of interest that corresponds to the selected subset of the dose volume histogram,

wherein the dose volume histogram is a dose volume histogram of a comparison between at least two dose volumes.

11. A method as set forth in claim 10 wherein one of the dose volumes is a planned radiation dose to be delivered to the patient.

12. A method as set forth in claim 10 wherein one of the dose volumes is a radiation dose previously delivered to the patient.

13. A method as set forth in claim 10 wherein one of the dose volumes is a combination of a planned radiation dose to be delivered to the patient and a radiation dose previously delivered to the patient.

14. A method as set forth in claim 10 wherein one of the dose volumes is one of a sum of or difference between previously delivered doses.

15. A method comprising using a computer to carry out the steps of:

generating a first dose volume representing a first radiation dose for a patient;

generating a second dose volume representing a second radiation dose for the patient;

comparing the first dose volume and the second dose volume;

generating a dose volume histogram based on the comparison;

selecting a subset on the dose volume histogram; and

generating a region of interest based on the selected subset.

16. The method as set forth in claim 15 wherein the comparison is a difference between the first radiation dose and the second radiation dose.

17. The method as set forth in claim 16 wherein the first radiation dose is a planned dose and the second radiation dose is a delivered dose.

18. The method as set forth in claim 15 wherein the region of interest is automatically generated.

19. The method as set forth in claim 15 wherein the delivered radiation dose is a sum of a plurality of delivered doses.

20. The method as set forth in claim 19 wherein the delivered doses are summed using deformation.

21. The method as set forth in claim 15 and further comprising generating a treatment plan for the patient and adapting the treatment plan based on the region of interest.

22. A system for generating contours using a dose volume histogram, the system comprising:

a radiation therapy treatment device including a computer processor, the radiation therapy treatment device operable to deliver a treatment plan to a patient; and

a software program stored in a computer readable medium accessible by the computer processor, the software being operable to generate a dose volume histogram of radiation dose for a pre-existing region of interest, select a subset of the dose volume histogram, and define a new region of interest that corresponds to the selected subset of the dose volume histogram.

23. The system as set forth in claim 22 wherein the software program includes an analysis module operable to generate the dose volume histogram of the patient radiation therapy dose.

24. The system as set forth in claim 22 wherein the software program includes a contour module operable to generate a contour on the image that corresponds to the dose volume histogram.

25. The system as set forth in claim 22 wherein the software program is further operable to generate a treatment plan and modify the treatment plan based on the new region of interest.

26. A method of defining a new region of interest using a dose volume histogram, the method comprising using a computer to carry out the steps of:

generating a first dose volume;

generating a second dose volume;

comparing the first dose volume and the second dose volume;

generating a histogram based on the comparison;

selecting a subset on the histogram; and

generating a region of interest based on the selected subset.

27. The method as set forth in claim 26 wherein the comparison is a difference between the first dose volume and the second dose volume.

28. The method as set forth in claim 26 wherein the region of interest is automatically generated.

29. The method as set forth in claim 26 and further comprising generating a treatment plan for the patient and adapting the treatment plan based on the region of interest.

30. The method as set forth in claim 26 wherein the comparison is based on a gamma index.

31. The method as set forth in claim 26 wherein the comparison is based on a xi function.

32. A method of defining a new region of interest using a histogram, the method comprising using a computer to carry out the steps of:

generating a histogram of radiation dose for a pre-existing region of interest;

selecting a subset of the histogram; and

defining a new region of interest that corresponds to the selected subset of the histogram.

33. A method as set forth in claim 32 wherein the histogram is a dose volume histogram.

34. A method as set forth in claim 32 and further comprising displaying a region on an image that corresponds to the selected subset of the histogram.

35. A method as set forth in claim 32 wherein the radiation dose is a dose delivered in one or more previous treatments.

36. A method as set forth in claim 32 wherein the radiation dose is a planned dose to be delivered to the patient.

37. A method as set forth in claim 32 and further comprising generating a treatment plan for the patient and wherein the new region of interest is used to modify the treatment plan.

38. A method as set forth in claim 32 wherein the new region of interest is an updated version of the existing region of interest.

39. A method as set forth in claim 32 wherein the radiation dose is a combination of a planned radiation dose to be delivered to the patient and a radiation dose previously delivered to the patient.

40. A method as set forth in claim 32 and further comprising adapting a treatment plan for the patient based on the new region of interest.

41. A method as set forth in claim 32 wherein the image is a dose map of a portion of the patient.

42. A method of defining a new region of interest using a histogram, the method comprising using a computer to carry out the steps of:

generating a histogram of radiation dose for a pre-existing region of interest;

selecting a subset of the histogram; and

defining a new region of interest that corresponds to the selected subset of the histogram, wherein the histogram is a dose volume histogram of a comparison between at least two dose volumes.

43. A method as set forth in claim 42 wherein one of the dose volumes is a planned radiation dose to be delivered to the patient.

44. A method as set forth in claim 42 wherein one of the dose volumes is a radiation dose previously delivered to the patient.

45. A method as set forth in claim 42 wherein one of the dose volumes is a combination of a planned radiation dose to be delivered to the patient and a radiation dose previously delivered to the patient.

46. A method as set forth in claim 42 wherein one of the dose volumes is one of a sum of or difference between previously delivered doses.

Assignments (12)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 8, 2025
From: ACCURAY INCORPORATED
To: ACCURAY LLC
Reel/Frame 072189/0891 →
RELEASE OF SECURITY INTEREST Recorded Jun 6, 2025
From: FIRST-CITIZENS BANK & TRUST COMPANY
To: ACCURAY INCORPORATED
Reel/Frame 071638/0034 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 11, 2023
From: TOMOTHERAPY INCORPORATED
To: ACCURAY INCORPORATED
Reel/Frame 064218/0337 →
RELEASE OF SECURITY INTEREST Recorded May 20, 2021
From: MIDCAP FINANCIAL TRUST
To: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
Reel/Frame 056318/0751 →
RELEASE OF SECURITY INTEREST Recorded May 20, 2021
From: MIDCAP FUNDING IV TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING X TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING IV TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST)
To: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
Reel/Frame 056318/0559 →
SECURITY INTEREST Recorded May 14, 2021
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: SILICON VALLEY BANK, AS ADMINISTRATIVE AND COLLATERAL AGENT
Reel/Frame 056247/0001 →
ASSIGNMENT OF SECURITY AGREEMENTS Recorded Mar 1, 2019
From: MIDCAP FUNDING X TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING IV TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST), AS EXISTING ADMINISTRATIVE AGENT
To: MIDCAP FUNDING IV TRUST, AS SUCCESSOR TO EXISTING ADMINISTRATIVE AGENT
Reel/Frame 048481/0804 →
SECURITY INTEREST Recorded Dec 19, 2017
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: MIDCAP FINANCIAL TRUST
Reel/Frame 044910/0685 →
SECURITY INTEREST Recorded Jun 15, 2017
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: MIDCAP FUNDING IV TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST)
Reel/Frame 042826/0358 →
RELEASE OF SECURITY INTEREST Recorded Jun 15, 2017
From: CERBERUS BUSINESS FINANCE, LLC. AS COLLATERAL AGENT
To: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
Reel/Frame 042821/0580 →
ASSIGNMENT FOR SECURITY - PATENTS Recorded Jan 13, 2016
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: CERBERUS BUSINESS FINANCE, LLC, AS COLLATERAL AGENT
Reel/Frame 037513/0170 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 22, 2006
From: KAPATOES, JEFFREY M.; OLIVERA, GUSTAVO H.; SCHNARR, ERIC; LU, WEIGUO; RUCHALA, KENNETH J.; RECKWERDT, PAUL J.; HUGHES, JOHN H.; MACKIE, THOMAS R.
To: TOMOTHERAPY INCORPORATED
Reel/Frame 018292/0761 →