Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents
View Patent ↗Cyanophenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration, treatment of disease and preparation are provided as well.
1. A method of regulating reproductive function in a patient in need thereof comprising administering an effective amount of a composition comprising:
(A) an active agent; and
(B) at least one compound having the formula:
or a salt thereof, wherein
R 1 , R 2 , R 3 , R 4 and R 5 are independently H, —CN, —OH, —OCH 3 , or halogen, at least one of R 1 , R 2 , R 3 , R 4 and R 5 being —CN; and
R 6 is C 1 -C 12 linear or branched alkylene, alkenylene, arylene, alkyl(arylene) or aryl(alkylene),
with the proviso that when R 1 is —CN, R 4 is H or —CN, and R 2 , R 3 , and R 2 are H, then R 6 is not (CH 2 ) 1 .
2. The method of claim 1 , wherein the active agent is luteinzing hormone releasing hormone.
3. A method of regulating reproductive function in a patient in need thereof comprising administering an effective amount of a composition comprising:
(A) an active agent; and
(B) a compound selected from the group consisting of:
and salts thereof.
4. The method of claim 3 wherein the active agent is luteinizing hormone releasing hormone.
5. The method of claim 1 wherein the active agent is follicle stimulating hormone.
6. The method of claim 3 wherein the active agent is follicle stimulating hormone.
7. The method of claim 3 , wherein the delivery agent is selected from compounds 1, 3, 4 and 9 and salts thereof.
8. The method of claim 4 , wherein the delivery agent is selected from compounds 1, 3, 4and 9and salts thereof.
9. The method of claim 6 , wherein the delivery agent is selected from compounds 1, 3, 4and 9and salts thereof.