IP Library Granted Patent US 7,390,834
Granted Patent B2
US 7,390,834 · App. 11/462,631 · Granted Jun 24, 2008

Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents

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Quick Facts
Patent No.
US 7,390,834
App. No.
11/462,631
Granted
Jun 24, 2008
Kind
B2
Abstract

Cyanophenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration, treatment of disease and preparation are provided as well.

Claims (18)

1. A method of regulating reproductive function in a patient in need thereof comprising administering an effective amount of a composition comprising:

(A) an active agent; and

(B) at least one compound having the formula:

or a salt thereof, wherein

R 1 , R 2 , R 3 , R 4 and R 5 are independently H, —CN, —OH, —OCH 3 , or halogen, at least one of R 1 , R 2 , R 3 , R 4 and R 5 being —CN; and

R 6 is C 1 -C 12 linear or branched alkylene, alkenylene, arylene, alkyl(arylene) or aryl(alkylene),

with the proviso that when R 1 is —CN, R 4 is H or —CN, and R 2 , R 3 , and R 2 are H, then R 6 is not (CH 2 ) 1 .

2. The method of claim 1 , wherein the active agent is luteinzing hormone releasing hormone.

3. A method of regulating reproductive function in a patient in need thereof comprising administering an effective amount of a composition comprising:

(A) an active agent; and

(B) a compound selected from the group consisting of:

and salts thereof.

4. The method of claim 3 wherein the active agent is luteinizing hormone releasing hormone.

5. The method of claim 1 wherein the active agent is follicle stimulating hormone.

6. The method of claim 3 wherein the active agent is follicle stimulating hormone.

7. The method of claim 3 , wherein the delivery agent is selected from compounds 1, 3, 4 and 9 and salts thereof.

8. The method of claim 4 , wherein the delivery agent is selected from compounds 1, 3, 4and 9and salts thereof.

9. The method of claim 6 , wherein the delivery agent is selected from compounds 1, 3, 4and 9and salts thereof.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 22, 2021
From: EMISPHERE TECHNOLOGIES, INC.
To: NOVO NORDISK NORTH AMERICA OPERATIONS A/S
Reel/Frame 056750/0169 →
SECURITY AGREEMENT Recorded Aug 8, 2006
From: EMISPHERE TECHNOLOGIES, INC.
To: MHR INSTITUTIONAL PARTNERS IIA LP
Reel/Frame 018073/0035 →