IP Library › Patent Application 11467509
Patent Application
App. No. 11/467,509

COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PYY PEPTIDE

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Patent No.
US None
App. No.
11/467,509
Abstract

Pharmaceutical compositions are described comprising PYY(3-36) (SEQ ID NO: 2), a solubilizing agent, a lipid, a polyol.

Claims (29)

1 . A peptide YY (PYY) composition comprised of PYY(3-36) (SEQ ID NO: 2), a solubilizing agent, a lipid, a polyol selected from the group consisting of sucrose, mannitol, sorbitol, lactose, L-arabinose, D-erythrose, D-ribose, D-xylose, D-mannose, trehalose, D-galactose, lactulose, cellobiose, gentibiose, glycerin and polyethylene glycol.

2 . The PYY composition of claim 1 wherein the solubilizing agent is selected from the group consisting of a cyclodextrin, hydroxypropyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin and methyl-β-cyclodextrin.

3 . The PYY composition of claim 2 wherein the solubilizing agent is a methyl-β-cyclodextrin.

4 . The PYY composition of claim 1 wherein the lipid is a phospholipid.

5 . The PYY composition of claim 4 wherein the phospholipid is a phosphatidylcholine.

6 . The PYY composition of claim 5 wherein the phosphatidylcholine is L-α-phosphatidylcholine didecanoyl (DDPC).

7 . The PYY composition of claim 1 wherein the polyol is sorbitol.

8 . The PYY composition of claim 1 wherein the composition is further comprised of a chelating agent.

9 . The PYY composition of claim 8 wherein the chelating agent is ethylene diamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA).

10 . The PYY composition of claim 9 wherein the chelating agent is EDTA.

11 . The PYY composition of claim 1 wherein the composition is an aqueous PYY composition further comprised of water.

12 . The PYY composition of claim 11 wherein the aqueous PYY composition has a pH of about of about 3 to about 6.

13 . The PYY composition of claim 12 wherein the pH of the aqueous PYY composition is 5.0±0.5.

14 . A PYY composition comprised of a solubilizing agent, a phosphatidylcholine, a polyol, and PYY(3-36) (SEQ ID NO: 2).

15 . The PYY composition of claim 14 wherein the polyol is selected from the group consisting of sucrose, mannitol, sorbitol, lactose, L-arabinose, D-erythrose, D-ribose, D-xylose, D-mannose, trehalose, D-galactose, lactulose, cellobiose, gentibiose, glycerin and polyethylene glycol.

16 . The PYY composition of claim 15 wherein the polyol is sorbitol.

17 . The PYY composition of claim 14 wherein the composition further comprises a chelating agent.

18 . The PYY composition of claim 17 wherein the chelating agent is ethylene diamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA).

19 . The PYY composition of claim 18 wherein the chelating agent is EDTA.

20 . The PYY composition of claim 14 wherein the solubilizing agent is selected from the group consisting of a cyclodextrin, hydroxypropyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin and methyl-β-cyclodextrin.

21 . The PYY composition of claim 20 wherein the solubilizing agent is a methyl-β-cyclodextrin.

22 . The PYY composition of claim 14 wherein the phosphatidylcholine is L-α-phosphatidylcholine didecanoyl (DDPC).

23 . The PYY composition of claim 14 wherein the composition is an aqueous PYY composition further comprised of water.

24 . The PYY composition of claim 23 wherein the aqueous PYY composition has a pH of about 3 to about 6.

25 . The PYY composition of claim 25 wherein the pH of the aqueous PYY composition is 5.0±0.5.

26 . A peptide YY (PYY) composition comprised of PYY(3-36) (SEQ ID NO: 2), a polyol, EDTA, and a surfactant selected from the group consisting of Tween 20, Tween 80, cetyl alcohol, and lanolin alcohol lipid.

27 . The PYY composition of claim 26 , where in polyol is selected from the group consisting of sucrose, mannitol, sorbitol, lactose, L-arabinose, D-erythrose, D-ribose, D-xylose, D-mannose, trehalose, D-galactose, lactulose, cellobiose, gentibiose, glycerin and polyethylene glycol.

28 . The PYY composition of claim 26 wherein the aqueous PYY composition has a pH of about 3 to about 6.

29 . The PYY composition of claim 26 wherein the pH of the aqueous PYY composition is 5.0±0.5.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2006
From: QUAY, STEVEN C.; BRANDT, GORDON; KLEPPE, MARY S.; MACEVILLY, CONOR J.
To: NASTECH PHARMACEUTICAL COMPANY INC.
Reel/Frame 018281/0513 →