Apparatus for producing tissue arrays
View Patent ↗An apparatus for producing a tissue array is described. At least one receiver block ( 1 ), and at least one donor block ( 2 ) that comprises tissue ( 3 ) to be investigated, are provided, a first hollow needle ( 4 ) for creating a cavity in the receiver block ( 1 ), and a second hollow needle ( 5 ) for removing a sample from the tissue ( 3 ) and introducing the sample ( 3 ) into the cavity of the receiver block ( 1 ), being present. A pantograph ( 6 ) is provided for positioning the first and/or the second hollow needle ( 4; 5 ) above the receiver block ( 1 ).
1. An apparatus for transferring a sample of tissue from a donor block containing tissue to be investigated to a receiver block of paraffin, the apparatus comprising:
a first hollow needle for creating a cavity in a receiver block;
a second hollow needle for removing a sample of tissue from a donor block and introducing the sample into the cavity in the receiver block; and
a pantograph including a first scissor arm and a second scissor arm joined to one another, wherein a position of the second scissor arm determines a position of the first scissor arm;
a needle holder joined to the first scissor arm for movement therewith, the needle holder carrying the first hollow needle and the second hollow needle;
a receptacle carried by the first scissor arm for movement therewith, the receptacle- and needle holder being movable relative to one another to align a selected one of the first and second hollow needles with the receptacle;
a punching lever operable through the receptacle to actuate the selected one of the first and second hollow needles; and
a turntable supporting the donor block and the receiver block for movement in a fixed plane relative to the pantograph.
2. The apparatus according to claim 1 , wherein the scissor arms are rotatably joined to one another at an intersection point.
3. The apparatus for according to claim 2 , wherein the second scissor arm includes a detent pin.
4. The apparatus according to claim 3 , further comprising a positioning array, wherein the detent pin is associated with the positioning array.
5. The apparatus according to claim 4 , wherein the positioning array comprises a plurality of detent holes for receiving the detent pin, each of the plurality of detent holes defining a position of the receptacle relative to the receiver block.
6. The apparatus according to claim 1 , wherein a plurality of first hollow needles and a plurality of second hollow needles, having different diameters, are arranged next to one another in a circular arc on the needle holder.