IP Library › Patent Application 11472044
Patent Application
App. No. 11/472,044

Dominant negative proteins and methods thereof

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
11/472,044
Abstract

The invention relates to novel proteins with TNFSF antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNFSF-related disorders.

Claims (4)

1 - 44 . (canceled)

45 . Method of treating a TNFSF mediated disease comprising: administration to a patient a variant TNFSF protein, wherein said variant TNFSF protein is capable of interacting with a naturally occurring TNFSF protein to form a mixed-dimer or mixed-trimer, and wherein said TNFSF mixed-dimer or mixed-trimer is substantially incapable of activating receptor signaling in the naturally occurring receptors in said patient.

46 . The method of claim 45 , wherein said TNFSF protein antagonized said naturally occurring TNFSF protein.

47 . The method of claim 45 , wherein said patient is human.