Self-preserving composition
The invention provides self-preserving compositions and methods for their production.
1 . A self-preserving composition comprising:
an anti-microbial buffer; and
an anti-microbial metal ion,
wherein a pH of the composition is between about 6.0 and about 8.0 and an osmolality of the composition is between about 200 and about 400 mOsm/kg.
2 . The composition of claim 1 , wherein the anti-microbial buffer includes at least one of the following: a borate buffer, an ethanolamine/biguanide buffer, a tricine buffer, a cetylpyridinium chloride buffer, and a cationic polysaccharide buffer.
3 . The composition of claim 2 , wherein the borate buffer includes at least one soluble salt of borate selected from a group consisting of: boric acid, sodium borate, and potassium borate.
4 . The composition of claim 1 , wherein the anti-microbial metal ion includes at least one of the following: a zinc ion, a silver ion, a nickel ion, an iron ion, a cobalt ion, a copper ion, a manganese ion, a gold ion, a chromium ion, a platinum ion, and a palladium ion.
5 . The composition of claim 1 , further comprising an antioxidant.
6 . The composition of claim 5 , wherein the antioxidant includes ascorbate.
7 . The composition of claim 6 , wherein the ascorbate includes at least one of ascorbic acid and a salt of ascorbic acid.
8 . The composition of claim 1 , further comprising a surfactant.
9 . The composition of claim 8 , wherein the surfactant includes polyoxyethylene sorbitan monooleate.
10 . The composition of claim 1 , further comprising a chelating agent.
11 . The composition of claim 10 , wherein the chelating agent includes ethylenediaminetetraacetic acid.
12 . The composition of claim 1 , wherein the composition is substantially free of preservatives.
13 . The composition of claim 12 , wherein the preservative is selected from a group consisting of: benzalkonium chloride, benzethonium chloride, benzyl alcohol, busan, cetrimide, chlorhexidine, chlorbutanol, edetate disodium, phenylmercuric nitrate, phenylmercuric acetate, thimerosal, methylparaben, propylparaben, phenylethyl alcohol, stabilized oxychloro compound, sorbic acid/potassium sorbate, polyaminopropyl biguanide, polyquaternium-1, polyhexamethylene biguanide, and polyvinylpyrrolidone-iodine complex.
14 . The composition of claim 1 , wherein the composition is suitable for at least one of the following: ophthalmic administration, otic administration, and nasal administration.
15 . A method for preserving a composition comprising:
incorporating into the composition an antimicrobial buffer; and
incorporating into the composition an antimicrobial metal ion.
16 . The method of claim 15 , wherein the anti-microbial buffer includes at least one of the following: a borate buffer, an ethanolamine/biguanide buffer, a tricine buffer, a cetylpyridinium chloride buffer, and a cationic polysaccharide buffer.
17 . The method of claim 16 , wherein the borate buffer includes at least one of the following: boric acid, sodium borate, and potassium borate.
18 . The method of claim 15 , wherein the anti-microbial metal ion includes at least one of the following: a zinc ion, a silver ion, a nickel ion, an iron ion, a cobalt ion, a copper ion, a manganese ion, a gold ion, a chromium ion, a platinum ion, and a palladium ion.
19 . The method of claim 15 , further comprising:
adjusting a pH of the composition to between about 6.5 and about 8.0.
20 . The method of claim 15 , further comprising:
adjusting an osmolality of the composition to between about 200 mOsm/kg and about 400 mOsm/kg.
21 . The method of claim 15 , further comprising:
incorporating into the composition an antioxidant.
22 . The method of claim 15 , further comprising:
incorporating into the composition a surfactant.
23 . The method of claim 15 , further comprising:
incorporating into the composition a chelating agent.
24 . The method of claim 15 , wherein the composition is selected from a group consisting of: ophthalmic compositions, otic compositions, and nasal compositions.
25 . A composition comprising:
an antimicrobial buffer;
ascorbic acid;
a source of zinc ions; and
polyoxyethylene sorbitan monooleate,
wherein precipitation of zinc is inhibited by the ascorbic acid.
26 . The composition of claim 25 , wherein the antimicrobial buffer includes a borate buffer.
27 . The composition of claim 25 , wherein the source of zinc ions includes at least one soluble salt of zinc selected from a group consisting of: zinc chloride, zinc sulfate, zinc acetate, and zinc lactate.
28 . The composition of claim 24 , wherein the composition is substantially free of preservatives.
29 . The composition of claim 28 , wherein the preservative is selected from a group consisting of: benzalkonium chloride, benzethonium chloride, benzyl alcohol, busan, cetrimide, chlorhexidine, chlorbutanol, edetate disodium, phenylmercuric nitrate, phenylmercuric acetate, thimerosal, methylparaben, propylparaben, phenylethyl alcohol, stabilized oxychloro compound, sorbic acid/potassium sorbate, polyaminopropyl biguanide, polyquaternium-1, polyhexamethylene biguanide, and polyvinylpyrrolidone-iodine complex.
30 . A method for treating an allergy symptom in an individual, the method comprising:
administering to a surface of at least one of an eye, an ear, and a nasal passage of an individual a composition comprising an effective amount of zinc,
wherein the zinc is capable of precipitating from the administered surface at least one protein causing a symptom of an allergic reaction.
31 . The method of claim 30 , wherein the effective amount of zinc includes at least one soluble salt of zinc selected from a group consisting of: zinc chloride, zinc sulfate, zinc acetate, and zinc lactate.
32 . The method of claim 30 , wherein the composition further comprises a quantity of ascorbic acid capable of inhibiting precipitation of zinc from the composition.
33 . The method of claim 30 , wherein the composition further includes an antimicrobial buffer.
34 . The method of claim 30 , wherein the composition further includes at least one antiallergy compound.
35 . The method of claim 34 , wherein the at least one antiallergy compound is selected from a group consisting of: cetirizine, olopatadine, cromolyn sodium, nephazoline, pheniramine, levocabastine, pemirolast, oxymetazoline, loratadine, tetrahydrozoline, nedocromil, and azelastine.
36 . A composition comprising:
a source of zinc,
wherein the source of zinc is capable of precipitating from a surface of at least one of an eye, an ear, and a nasal passage, at least one protein capable of causing at least one symptom of an allergic reaction.
37 . The composition of claim 36 , wherein the source of zinc includes at least one soluble salt of zinc selected from a group consisting of: zinc chloride, zinc sulfate, zinc acetate, and zinc lactate.
38 . The composition of claim 36 , further comprising:
a quantity of ascorbic acid capable of inhibiting precipitation of zinc from the composition.
39 . The composition of claim 36 , further comprising an antimicrobial buffer.
40 . The composition of claim 36 , further comprising at least one antiallergy compound.
41 . The composition of claim 40 , wherein the at least one antiallergy compound is selected from a group consisting of: cetirizine, olopatadine, cromolyn sodium, nephazoline, pheniramine, levocabastine, pemirolast, oxymetazoline, loratadine, tetrahydrozoline, nedocromil, and azelastine.