Postpartum cells derived from umbilical cord tissue, and methods of making and using the same

1. A homogeneous population of cells isolated from umbilicus tissue substantially free of blood wherein said homogeneous population of cells expresses CD10, CD13, CD44, CD73, CD90, PDGFr-alpha, and HLA-A,B,C, and does not express CD31, CD34, CD 45, CD117, CD141, and HLA-DR,DP,DQ.

2. The isolated cell population of claim 1 , wherein the cell population expresses a gene for one or more of interleukin 8; reticulon 1; chemokine (C-X-C motif) ligand 1; chemokine (C-X-C motif) ligand 6; chemokine (C-X-C motif) ligand 3; or tumor necrosis factor-alpha-induced protein 3.

3. The isolated cell population of claim 1 , wherein the cell population expresses a gene for each of interleukin 8; reticulon 1; chemokine (C-X-C motif) ligand 1; chemokine (C-X-C motif) ligand 6; chemokine (C-X-C motif) ligand 3; and tumor necrosis factor-alpha-induced protein 3.

4. The isolated cell population of claim 3 wherein the expression is increased relative to that of a human cell which is a fibroblast, a mesenchymal stem cell or an iliac crest bone marrow cell.

5. The isolated cell population of claim 1 , which relative to a human cell that is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell, has reduced expression of one or more genes selected from the group consisting of: short stature homeobox 2; heat shock 27 kDa protein 2; chemokine (C-X-C motif) ligand 12; elastin; Homo sapiens mRNA; cDNA DKFZp586M2022 (from clone DKFZp586M2022); mesenchyme homeobox 2; sine oculis homeobox homolog 1 ( Drosophila ); crystallin, alpha B; dishevelled associated activator of morphogenesis 2; DKFZP586B2420 protein; similar to neuralin 1; tetranectin; src homology three (SH3) and cysteine rich domain; B-cell translocation gene 1, anti-proliferative; cholesterol 25-hydroxylase; runt-related transcription factor 3; hypothetical protein FLJ23191; interleukin 11 receptor-alpha; procollagen C-endopeptidase enhancer; frizzled homolog 7 ( Drosophila ); hypothetical gene BC008967; collagen type VIII, alpha 1; tenascin C (hexabrachion); iroquois homeobox protein 5; hephaestin; integrin beta 8; synaptic vesicle glycoprotein 2; Homo sapiens cDNA FLJ12280 fis, clone MAMMA1001744; cytokine receptor-like factor 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; integrin alpha 7; DKFZP586L151 protein; transcriptional co-activator with PDZ-binding motif; sine oculis homeobox homolog 2 ( Drosophila ); KIAA1034 protein; early growth response 3; distal-less homeobox 5; hypothetical protein FLJ20373; aldo-keto reductase family 1, member C3; biglycan; fibronectin 1; proenkephalin; integrin beta-like 1 (with EGF-like repeat domains); Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1968422; EphA3; KIAA0367 protein; natriuretic peptide receptor C/guanylate cyclase C; hypothetical protein FLJ14054; Homo sapiens mRNA; cDNA DKFZp564B222 (from clone DKFZp564B222); vesicle-associated membrane protein 5; EGF-containing fibulin-like extracellular matrix protein 1; BCL2/adenovirus EIB 19 kpa interacting protein 3-like; AE binding protein 1; cytochrome c oxidase subunit VIIa polypeptide; neuroblastoma suppression of tumorigenicity 1; and insulin-like growth factor binding protein 2, 36 kDa.

6. The isolated cell population of claim 5 , wherein the cell population expresses a gene for one or more of interleukin 8; reticulon 1; chemokine (C-X-C motif) ligand; chemokine (C-X-C motif) ligand 6; chemokine (C-X-C motif) ligand 3; or tumor necrosis factor alpha-induced protein 3, wherein the expression is increased relative to that of a human cell which is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell.

7. The isolated cell population of claim 6 , which relative to a human cell that is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell, has reduced expression of genes for each of: short stature homeobox 2; heat shock 27 kDa protein 2; chemokine (C-X-C motif) ligand 12; elastin; Homo sapiens mRNA; cDNA DKFZp586M2022 (from clone DKFZp586M2022); mesenchyme homeobox 2; sine oculis homeobox homolog 1 ( Drosophila ); crystallin alpha B; dishevelled associated activator of morphogenesis 2; DKFZP586B2420 protein; similar to neuralin 1; tetranectin; src homology three (SH3) and cysteine rich domain; B-cell translocation gene 1 anti-proliferative; cholesterol 25-hydroxylase; runt-related transcription factor 3; hypothetical protein FLJ23191; interleukin 11 receptor alpha; procollagen C-endopeptidase enhancer; frizzled homolog 7 ( Drosophila ); hypothetical gene BC008967; collagen type VIII, alpha 1; tenascin C (hexabrachion); iroquois homeobox protein 5; hephaestin; integrin, beta 8; synaptic vesicle glycoprotein 2; Homo sapiens cDNA FLJ12280 fis, clone MAMMA1001744; cytokine receptor-like factor 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; integrin, alpha 7; DKFZP586L151 protein; transcriptional co-activator with PDZ-binding motif (TAZ); sine oculis homeobox homolog 2 ( Drosophila ); KIAA1034 protein; early growth response 3; distal-less homeobox 5; hypothetical protein FLJ20373; aldo-keto reductase family 1 member C3; biglycan; fibronectin 1; proenkephalin; integrin beta-like 1; Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1968422; EphA3; KIAA0367 protein; natriuretic peptide receptor C/guanylate cyclase C; hypothetical protein FLJ14054; Homo sapiens mRNA; cDNA DKFZp564B222 (from clone DKFZp564B222); vesicle-associated membrane protein 5; EGF-containing fibulin-like extracellular matrix protein 1; BCL2/adenovirus E1B 19 kDa interacting protein 3-like; AE binding protein 1; cytochrome c oxidase subunit VIIa polypeptide 1; neuroblastoma suppression of tumorigenicity 1; and insulin-like growth factor binding protein 2, 36 kDa.

8. The isolated cell population of claim 7 , wherein the cell population expresses a gene for each of interleukin 8; reticulon 1; chemokine (C-X-C motif) ligand; chemokine (C-X-C motif) ligand 6; chemokine (C-X-C motif) ligand 3; and tumor necrosis factor alpha-induced protein 3, wherein the expression is increased relative to that of a human cell which is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell.

9. The isolated cell population of claim 1 , wherein the cell population shows increased expression of a gene for each of interleukin 8; reticulon 1; and chemokine (C-X-C motif) ligand 3 relative to that of a human cell which is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell.