Compositions and method for the reduction of post-operative pain
View Patent ↗At least three component, body-implantable, absorbable, biocompatible, putty, and non-putty pain-relieving compositions for use in surgery comprising in intimate admixture: an analgesic having local pain-relieving activity for internal relief of pain, a finely powdered bulking material, preferably less than 50 microns, e.g. the metal salts of fatty acid, hydroxyapatite, DBM, polyglycolide, polylactide, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. An organic liquid capable of solubilizing, dispensing or suspending the analgesic, such as esters of monohydric alcohols with aliphatic monocarboxylic acids; C 2 -C 18 monohydric alcohols with polycarboxylic acids; C 8 -C 30 monohydric alcohols; tocopherol and esters thereof with mono or polycarboxylic acids; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; polyhydroxy compounds and esters and ethers thereof; random or block copolymers of ethylene oxide and propylene oxide.
1. An anhydrous, body-absorbable, mechanically hemostatic putty composition comprising the following Components 1, 2, and 3:
Component 1: a finely powdered metal salt of a fatty acid having a carboxylate anion and a metallic cation;
Component 2: an anhydrous organic liquid comprising:
(a) a tocopherol selected from the group consisting of tocopherol, a C 2 -C 10 aliphatic monocarboxylic acid ester of tocopherol, a polycarboxylic acid ester of tocopherol, and mixtures thereof, and
(b) a block copolymer of ethylene oxide and propylene oxide, and
Component 3: a free base form of an analgesic;
wherein Component 2 makes up 20 to 60% of the composition by weight and wherein member (a) of Component 2 makes up 5 to 44% of the composition by weight.
2. The composition of claim 1 , further comprising an acid addition salt of the analgesic.
3. The composition of claim 1 wherein the carboxylate anion is selected from saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms.
4. The composition of claim 1 wherein the carboxylate salt cation is calcium, magnesium, zinc, aluminum, or barium or mixtures thereof.
5. The composition of claim 4 wherein the carboxylate salt cation is calcium.
6. The composition of claim 4 wherein the carboxylate salt cation is aluminum.
7. The composition of claim 1 wherein the carboxylic acid supplying the carboxylate anion is an aliphatic acid selected from caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, and intervening homologs thereof.
8. The composition of claim 7 wherein the carboxylate anion is derived from stearic acid.
9. The composition of claim 7 wherein the carboxylate anion is derived from palmitic acid.
10. The composition of claim 1 , wherein the C 2 -C 10 aliphatic monocarboxylic acid ester of tocopherol is tocopheryl acetate.
11. The composition of claim 1 , wherein the analgesic is selected from the group consisting of benzocaine, bupivacaine, dibucaine, lidocaine, mepivacaine, prilocaine, procaine, chloroprocaine, etidocaine, tetracaine, and ropivacaine.
12. The composition of claim 11 , wherein the analgesic is lidocaine.
13. The composition of claim 2 , wherein the analgesic is selected from the group consisting of benzocaine, bupivacaine, dibucaine, lidocaine, mepivacaine, prilocaine, procaine, chloroprocaine, etidocaine, tetracaine, and ropivacaine.
14. The composition of claim 13 , wherein the analgesic is lidocaine.
15. The composition of claim 2 , wherein the acid addition salt of the analgesic is a hydrohalide.
16. The composition of claim 15 , wherein the hydrohalide is hydrochloride or hydrobromide.
17. The composition of claim 2 , wherein the analgesic is released over a period of from about 0 to 8 days.
18. The composition of claim 17 , wherein the analgesic is released over a period of about 8 days.