Granted Patent B2

US 7,824,659 · App. 11/492,729 · Granted Nov 2, 2010

Abstract

Claims (31)

1. A compound of formula (I)

wherein

Sup is a solid support, resin, polymer, or macromolecular matrix;

X and Y are independently at each occurrence S, O, or —(CH 2 )—;

n is 0 to 6; and

R is C 1-6 alkyl.

2. The following is an examiner's statement of reasons for allowance: the compounds of the instant claims are free of the prior art. The closest prior art U.S. Pat. No. 7,344,702 provides for the compounds,

but does not teach of the compounds above bound to the —OSO 2 -Sup group of the instant claims.

3. The compound of claim 1 of formula (II)

4. A radiopharmaceutical kit for the preparation of an 18 F-labeled tracer for use in Positron Emission Tomography, comprising

(i) a vessel containing a compound of formula (I)

 or a pharmaceutically acceptable salt thereof, wherein

Sup is a solid support, resin, polymer, or macromolecular matrix;

X and Y are independently at each occurrence S, O, or —(CH 2 )—;

n is 0 to 6; and

R is C 1-6 alkyl;

(ii) means for eluting the vessel with a source of 18 F − ;

(iii) an ion-exchange cartridge for removal of excess 18 F − ; and

(iv) an optional cartridge for solid-phase purification of a compound of formula (Ia)

wherein

X and Y are independently each occurrence S, O, or —(CH 2 )—;

n is 0 to 6; and

R is C 1-6 alkyl.

5. A cartridge for a radiopharmaceutical kit used in the preparation of an 18 F-labeled tracer for use in Positron Emission Tomography comprising

(i) a vessel containing a compound of formula (I)

 or a pharmaceutically acceptable salt thereof, wherein

Sup is a solid support, resin, polymer, or macromolecular matrix;

X and Y are independently at each occurrence S, O, or —(CH 2 )—;

n is 0 to 6; and

R is C 1-6 alkyl; and

(ii) means for eluting the vessel with a source of 18 F − .

Assignments (13)