Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.
1. An implantable medical device comprising:
a random copolymer composition disposed on a structure;
the random copolymer composition and the structure being configured for implanting into a subject;
the random copolymer composition comprising a therapeutic agent and a butyl methacrylate-co-acrylamido-methyl-propane sulfonate random copolymer; wherein the random copolymer composition provides controlled release of the therapeutic active agent from the medical device into the subject; and wherein the medical device is selected from the group consisting of vascular devices, peripheral cardiovascular devices, surgical devices, orthopedic devices, dental devices, drug delivery devices, ophthalmic devices, urological devices, synthetic prostheses, respiratory devices, neurological devices, ear nose and throat devices, biosensor devices, oncological implants and pain management implants.
2. The device of claim 1 , wherein the random copolymer comprises acrylamido-methyl-propane sulfonate at about 1.5 mol-%, about 3 mol-%, or about 9 mol-%.
3. The device of claim 1 , wherein the random copolymer comprises acid form of acrylamido-methyl-propane sulfonate.
4. The device of claim 1 , wherein the random copolymer comprises alkali metal salt of acrylamido-methyl-propane sulfonate.
5. The device of claim 1 , the structure comprising a base material.
6. The device of claim 1 , the structure comprising a surface, the composition being disposed on the surface.
7. The device of claim 1 , wherein the therapeutic active-agent is charged.
8. The device of claim 1 , wherein the therapeutic agent has a molecular weight of less than 2 kD and has a water solubility of greater than 10 mg/mL at 25° C.
9. The device of claim 1 , wherein the random copolymer composition comprises a plurality of therapeutic agents.
10. The device of claim 9 , wherein the plurality of therapeutic agents comprises a charged therapeutic agent and a hydrophobic therapeutic agent.
11. The device of claim 1 , wherein the random copolymer composition further comprises a second (blend) polymer.
12. The device of claim 1 , wherein the random copolymer composition is hemocompatible.
13. An implantable medical device comprising:
a random copolymer composition disposed on a structure
the random copolymer and the structure being configured for implanting into a subject;
the random copolymer composition comprising a butyl methacrylate-co-acrylamido-methyl-propane sulfonate random copolymer;
wherein the random copolymer composition is hemocompatible; and wherein the medical device is selected from the group consisting of vascular devices, peripheral cardiovascular devices, surgical devices, orthopedic devices, dental devices, drug delivery devices, ophthalmic devices, urological devices, synthetic prostheses, respiratory devices, neurological devices, ear nose and throat devices, biosensor devices, oncological implants, and pain management implants.
14. The device of claim 13 , wherein the random copolymer comprises about 10 to about 20 mol-% acrylamido-methyl-propane sulfonate.
15. The device of claim 13 , wherein the random copolymer comprises the acid form of acrylamido-methyl-propane sulfonate.
16. The device of claim 13 , wherein the random copolymer comprises alkali metal salt of acrylamido-methyl-propane sulfonate.
17. The device of claim 13 , further comprising a polymer composition including elutable active agent disposed between the structure and the hemocompatible random copolymer composition.
18. The device of claim 17 , wherein the polymer composition including elutable active agent comprises the random copolymer composition.
19. The device of claim 13 , the structure comprising a base material.
20. The device of claim 13 , the structure comprising a surface, the composition being disposed on the surface.
21. The device of claim 13 , wherein the device is implanted into a subject.
22. The device of claim 13 , wherein the random copolymer composition further comprises a second (blend) polymer.
23. The device of claim 13 , wherein the random copolymer comprises about 15 mol-% acrylamido-methyl-propane sulfonate.