System and method for use of agent in combination with subatmospheric pressure tissue treatment
A method and apparatus for the introduction to a wound under subatmospheric pressure therapy of a wound healing agent, generally comprises a foam pad ( 11 ) for insertion substantially into a wound site ( 12 ), and a wound drape ( 13 ) for sealing enclosure of the foam pad at the wound site. The foam pad is placed in fluid communication with a subatmospheric pressure source for promotion of fluid drainage. Additionally, the foam pad is predisposed, through grafting or other techniques known to those of ordinary skill in the art, with basic fibroblast growth factor (bFGF), anti-microbial or other factors, also known to those of ordinary skill in the art, for the promotion of increased wound healing.
1 . A system for treating tissue, the system comprising:
a screen placed in contact with the tissue;
a source of subatmospheric pressure;
a cover defining a space between the cover and the tissue;
a conduit connected between the source of subatmospheric pressure and the cover, wherein the conduit provides a pathway for application of a subatmospheric pressure within the space defined by the cover;
wherein the surfaces of at least a portion of the screen are uniformly covered with a coating solution comprising a plurality of silver ions;
wherein interior and exterior surfaces of the at least a portion of the screen are uniformly covered with a coating; and
wherein the coating releases a plurality of silver ions within the spaced defined by the cover.
2 . The system of claim 1 , wherein the coating releases the plurality of silver ions in the presence of an aqueous environment.
3 . The system of claim 1 , wherein the plurality of silver ions reduce bacterial density within the space defined by the cover.
4 . The system of claim 1 , wherein the uniformly covered portion of the screen includes at least one material selected from a group including foam, yarn, film, filament, fiber, fabric, and filler material.
5 . The system of claim 4 , wherein the foam comprises polyurethane or polyvinylalcohol.
6 . The system of claim 4 , wherein the fiber includes at least one substance selected from the group including nylon, polyester, acrylic, rayon, cotton, polyurethane, other polymeric materials and cellulose.
7 . The system of claim 1 , further comprising an area of contact between the tissue and the uniformly covered portion of the screen, wherein the area of contact increases as the screen conforms to the contacted tissue surface during application of the subatmospheric pressure within the space defined by the cover.
8 . The system of claim 7 , wherein the coating releases the plurality of silver ions to the increased area of contacted tissue.
9 . The system of claim 8 , wherein the plurality of silver ions reduce bacterial density on the increased area of contacted tissue.
10 . The system of claim 1 , wherein the screen further comprises a plurality of flow ports to allow gas and body-liquid to pass through the screen.
11 . The system of claim 10 , wherein the plurality of flow ports are uniformly covered with the coating.
12 . The system of claim 11 , wherein the plurality of flow ports are impregnated with the plurality of silver ions released from the coating.
13 . The system of claim 12 , wherein the plurality of silver ions reduce bacterial density within the screen.
14 . The system of claim 1 , wherein the uniformly covered portion of the screen comprises a coating selected from a group including a metallic coating and a polymer coating.
15 . The system of claim 14 , wherein application of the coating utilizing an electroless reduction-oxidation process.
16 . The system of claim 1 , wherein the coating includes at least one wound healing factor selected from a group including antimicrobial agents, debriding agents, anesthetic agents, chemotherapeutic agents, indicating agents, and growth factors.
17 . The system of claim 16 , wherein the growth factor is at least one growth factor selected from a group including basic fibroblast growth factor, transforming growth factor, epidermal growth factor, platelet derived growth factor, insulin-like growth factor, keratinocyte growth factor, fibroblast growth factor, granulocyte macrophage colony stimulating factor, and granulocyte colony stimulating factor.
18 . The system of claim 1 , wherein the tissue is at least one tissue selected from a group including bone tissue, adipose tissue, muscle tissue, dermal tissue, vascular tissue, connective tissue, cartilage, tendon, and ligament.
19 . The system of claim 1 , wherein the tissue is at least a portion of a wound.
20 . The system of claim 19 , wherein the wound is at least one wound selected from a group including partial thickness burns, traumatic wounds, surgical wounds, dehisced wounds, diabetic wounds, pressure ulcers, leg ulcers, flaps and grafts.
21 . A system for treating tissue, the system comprising:
a screen placed in contact with the tissue;
a source of subatmospheric pressure;
a cover defining a space between the cover and the tissue;
a pathway connected between the source of subatmospheric pressure and the cover, wherein the pathway provides for application of a subatmospheric pressure within the space defined by the cover; and
wherein at least a portion of the screen comprises silver and releases silver ions within the space defined by the cover.
22 . The system of claim 21 , wherein the silver ions reduce bacterial density within the space defined by the cover.
23 . The system of claim 21 , wherein the at least a portion of the screen further includes at least one material selected from a group including foam, yarn, film, filament, fiber, fabric, and filler material.
24 . The system of claim 23 , wherein the foam comprises polyurethane or polyvinylalcohol.
25 . The system of claim 23 , wherein the fiber includes at least one substance selected from the group including nylon, polyester, acrylic, rayon, cotton, polyurethane, other polymeric materials and cellulose.
26 . The system of claim 21 , further comprising an area of contact between the tissue and the at least a portion of the screen, wherein the area of contact increases as the screen conforms to the contacted tissue surface during application of the subatmospheric pressure within the space defined by the cover.
27 . The system of claim 26 , wherein the silver ions are released to the increased area of contacted tissue.
28 . The system of claim 27 , wherein the silver ions reduce bacterial density on the increased area of contacted tissue.
29 . The system of claim 21 , wherein the at least a portion of the screen further comprises a plurality of flow ports to allow gas and body-liquid to pass through the at least a portion of the screen.
30 . The system of claim 29 , wherein the at least a portion of the screen is impregnated with the silver ions.
31 . The system of claim 30 , wherein the silver ions reduce bacterial density within the at least a portion of the screen.
32 . The system of claim 21 , wherein the tissue is at least one tissue selected from a group including bone tissue, adipose tissue, muscle tissue, dermal tissue, vascular tissue, connective tissue, cartilage, tendon, and ligament.
33 . The system of claim 21 , wherein the tissue is at least a portion of a wound.
34 . The system of claim 33 , wherein the wound is at least one wound selected from a group including partial thickness burns, traumatic wounds, surgical wounds, dehisced wounds, diabetic wounds, pressure ulcers, leg ulcers, flaps and grafts.
35 . A method for treating tissue, the method comprising the steps of:
forming a screen, wherein the screen comprises a substrate uniformly covered with a coating solution comprising silver ions, and wherein at least one coated surface of the uniformly covered substrate is exposed when the screen is severed for fitting a tissue site;
positioning the screen in contact with the tissue;
placing a cover over the screen to define a space between the cover and the tissue;
connecting a conduit between the space defined by the cover and a source of subatmospheric pressure to provide a pathway for applying a subatmospheric pressure within the space defined by the cover; and
releasing silver ions within the space defined by the cover
36 . The method of claim 35 , wherein the silver ions are released in the presence of an aqueous environment.
37 . The method of claim 35 , further comprising the step of reducing bacterial density within the space defined by the cover.
38 . The method of claim 3 5 , wherein the substrate includes at least one material selected from a group including foam, yarn, film, filament, fiber, fabric, and filler material.
39 . The method of claim 38 , wherein the foam comprises polyurethane or polyvinylalcohol.
40 . The method of claim 38 , wherein the fiber includes at least one substance selected from the group including nylon, polyester, acrylic, rayon, cotton, polyurethane, other polymeric materials and cellulose.
41 . The method of claim 35 , further comprising the step of increasing an area of contact between the tissue and the screen by applying the subatmospheric pressure within the space defined by the cover.
42 . The method of claim 41 , further comprising the step of releasing the silver ions to the increased area of contacted tissue.
43 . The method of claim 42 , further comprising the step of reducing bacterial density on the increased area of contacted tissue.
44 . The method of claim 35 , wherein the tissue is at least one tissue selected from a group including bone tissue, adipose tissue, muscle tissue, dermal tissue, vascular tissue, connective tissue, cartilage, tendon, and ligament.
45 . The method of claim 3 . 5 , wherein the tissue is at least a portion of a wound.
46 . The method of claim 45 , wherein the wound is at least one wound selected from a group including partial thickness burns, traumatic wounds, surgical wounds, dehisced wounds, diabetic wounds, pressure ulcers, leg ulcers, flaps and grafts.
47 . A system for promoting wound healing, the system comprising:
a screen, wherein the screen is permeable to gases and body-liquid, and wherein at least a first healing factor is grafted into the screen,
a conduit having a first end in fluid communication with the screen and a second end in fluid communication with a source of subatmospheric pressure;
wherein the screen is adapted for positioning within a sealable space defined in part by a wound surface; and
wherein the source of subatmospheric pressure applies subatmospheric pressure to the screen through the conduit.
48 . The system of claim 47 , wherein the first healing factor comprises basic fibroblast growth factor.
49 . The system of claim 47 , wherein the first healing factor comprises an antimicrobial agent.
50 . The system of claim 49 , wherein the antimicrobial agent is bacteriostatic.
51 . The system of claim 47 , wherein a second healing factor comprises an antimicrobial agent.
52 . The system of claim 47 , wherein the subatmospheric pressure wound therapy system further comprises a cover for sealing the screen within the sealable space.