Aryl pyridines and methods of their use
View Patent ↗Aryl pyridines, compositions comprising them, and methods of their use for the treatment, prevention and management of a variety of diseases and disorders are disclosed.
1. A compound of formula I:
or a pharmaceutically acceptable salt or solvate thereof, wherein:
A is
R a is hydrogen, halogen or optionally substituted alkyl;
R b is hydrogen, halogen or optionally substituted alkyl;
each of R 1 , R 2 , R 3 , R 4 , R 5 is independently hydrogen, halogen, or optionally substituted heterocycle; or R 1 and R 2 , R 2 and R 3 , R 3 and R 4 , or R 4 and R 5 , together with the carbon atoms to which they are attached, form a pyrrolidinone ring;
each of R 6 and R 7 is independently hydrogen, halogen or optionally substituted alkyl; and
R 8 is an optionally substituted heterocycle or —NR c R d , —C(O)NR c R d , or —C(O)R e ,
wherein each of R c , R d and R e is independently hydrogen or optionally substituted alkyl;
provided that if each of R a , R b and R 1 -R 7 is hydrogen, then R 8 is not NH 2 .
2. The compound of claim 1 , wherein R 1 is the same as R 5 .
3. The compound of claim 1 , wherein R 1 is the same as R 4 and R 5 .
4. The compound of claim 1 , wherein R 1 is hydrogen.
5. The compound of claim 1 , wherein R 2 is an optionally substituted Heterocycle.
6. The compound of claim 1 , wherein R 3 is hydrogen.
7. The compound of claim 1 , wherein R 4 is hydrogen.
8. The compound of claim 1 , wherein R 5 is hydrogen.
9. The compound of claim 1 , wherein R 6 is the same as R 7 .
10. The compound of claim 1 , wherein R 6 is hydrogen.
11. The compound of claim 1 , wherein R 7 is hydrogen.
12. The compound of claim 1 , wherein R 8 is —C(O)NH 2 .
13. The compound of claim 1 , wherein R 8 is —C(O)-alkyl.
14. The compound of claim 1 , wherein R 8 is tetrazole.
15. A compound of formula II:
or a pharmaceutically acceptable salt or solvate thereof, wherein:
R a is hydrogen, halogen or optionally substituted alkyl;
R b is hydrogen, halogen or optionally substituted alkyl;
each of R 1 , R 2 , R 3 , R 4 , R 5 is independently hydrogen, halogen, or optionally substituted heterocycle; or R 1 and R 2 , R 2 and R 3 , R 3 and R 4 , or R 4 and R 5 , together with the carbon atoms to which they are attached, form a pyrrolidinone ring;
each of R 6 and R 7 is independently hydrogen, halogen or optionally substituted alkyl; and
R 8 is an optionally substituted heterocycle or —NR c R d , —C(O)NR c R d , or —C(O)R e ,
wherein each of R c , R d and R e is independently hydrogen or optionally substituted alkyl;
provided that if each of R a , R b and R 1 -R 7 is hydrogen, then R 8 is not NH 2 .