Amino acid-based nutritional formulations
View Patent ↗The present invention relates to an amino acid-based nutritional formulation comprising, per 100 g total amino acids, between about 4.5 and about 5 g glutamate. The ratio of cysteine:methionine is in the range of about 0.9:1 to about 1:1.2. The nutritional formulation may also comprise a lipid source, a carbohydrate source, an emulsifier comprising CITREM or DATEM, and amino acids, wherein glutamate is present in an amount of between about 4.5 and about 5 g per 100 g total amino acids.
1. A protein-free, amino acid-based infant formula comprising, per 100 g total amino acids, between 4.5 and 5 g glutamate, wherein the ratio of cysteine:methionine is 0.9:1 to 1:1.2 and wherein an average particle size of the infant formula is in a range of 0.6 μm to 3.5 μm.
2. The infant formula of claim 1 comprising 5 g glutamate.
3. The infant formula of claim 1 comprising between 150 and 200 mg glutamate per 100 kcal of the infant formula.
4. The infant formula of claim 1 comprising between 160 and 180 mg glutamate per 100 kcal of the infant formula.
5. The infant formula of claim 1 comprising 167 mg glutamate per 100 kcal of the infant formula.
6. The infant formula of claim 1 wherein glutamate comprises 5% of the total amino acids.
7. The infant formula of claim 1 , wherein the ratio of cysteine:methionine is 1:1.138.
8. The infant formula of claim 1 comprising between 50 and 100 mg cysteine per 100 kcal of the infant formula.
9. The infant formula of claim 1 comprising between 60 and 80 mg cysteine per 100 kcal of the infant formula.
10. The infant formula of claim 1 comprising between 70 and 75 mg cysteine per 100 kcal of the infant formula.
11. The infant formula of claim 1 comprising 73.5 mg cysteine per 100 kcal of the infant formula.
12. The infant formula of claim 1 comprising between 50 and 100 mg methionine per 100 kcal of the infant formula.
13. The infant formula of claim 1 comprising between 60 and 80 mg methionine per 100 kcal of the infant formula.
14. The infant formula of claim 1 comprising between 60 and 70 mg methionine per 100 kcal of the infant formula.
15. The infant formula of claim 1 comprising 64.6 mg methionine per 100 kcal of the infant formula.
16. The infant formula of claim 1 , further comprising citric acid glyceride ester.
17. The infant formula of claim 1 in a form selected from the group consisting of powder, liquid, and ready-to-use.
18. A protein-free infant formula comprising:
a) 3 to 7 grams of a lipid source per 100 kcal of infant formula;
b) 8 to 12 grams of a carbohydrate source per 100 kcal of infant formula;
c) an emulsifier comprising citric acid glyceride ester; and
d) amino acids, wherein glutamate is present in an amount of between 4.5 and 5 g per 100 g total amino acids, wherein the ratio of cysteine:methionine is 0.9:1 to 1:1.2 and wherein an average particle size of the infant formula is in a range of 0.6 μm to 3.5 μm.
19. The infant formula according to claim 18 , wherein citric acid glyceride ester is present in an amount of between 0.1 and 1.0 kg/100 kg infant formula.
20. The infant formula according to claim 18 , wherein citric acid glyceride ester is present in an amount of between 0.4 and 0.5 kg/100 kg infant formula.
21. The infant formula according to claim 18 , wherein citric acid glyceride ester is present in an amount of 0.488 kg/100 kg infant formula.
22. The infant formula according to claim 18 , wherein the pH of the infant formula is between 6 and 7.
23. The infant formula of claim 18 in a form selected from the group consisting of powder, liquid, and ready-to-use.
24. The infant formula of claim 18 , wherein the viscosity of the infant formula is less than 20 cps at ambient temperature.
25. The infant formula of claim 1 , wherein the infant formula contains no measurable amount of protein.
26. A protein-free, nutritionally complete infant formula comprising, 3 to 7 grams of a lipid source per 100 kcal of infant formula; 8 to 12 grams of a carbohydrate source per 100 kcal of infant formula; and between 4.5 and 5 g glutamate per 100 g total amino acids, wherein the ratio of cysteine:methionine is 0.9:1 to 1:1.2 and wherein an average particle size of the infant formula is in a range of 0.6 μm to 3.5 μm.
27. The infant formula of claim 26 comprising 5 g glutamate.
28. The infant formula of claim 26 comprising between 150 and 200 mg glutamate per 100 kcal of the infant formula.
29. The infant formula of claim 26 comprising between 160 and 180 mg glutamate per 100 kcal of the infant formula.
30. The infant formula of claim 26 , wherein glutamate comprises 5% of the total amino acids.
31. The infant formula of claim 26 , wherein the ratio of cysteine:methionine is 1:1.138.
32. The infant formula of claim 26 comprising between 50 and 100 mg cysteine per 100 kcal of the nutritional formulation.
33. The infant formula of claim 26 comprising between 60 and 80 mg cysteine per 100 kcal of the infant formula.
34. The infant formula of claim 26 comprising between 70 and 75 mg cysteine per 100 kcal of the infant formula.
35. The infant formula of claim 26 comprising 73.5 mg cysteine per 100 kcal of the infant formula.
36. The infant formula of claim 26 comprising between 50 and 100 mg methionine per 100 kcal of infant formula.
37. The infant formula of claim 26 comprising between 60 and 80 mg methionine per 100 kcal of the infant formula.
38. The infant formula of claim 26 , further comprising citric acid glyceride ester.
39. The infant formula of claim 26 in a form selected from the group consisting of powder, liquid, and ready-to-use.