Methods and compositions for reducing skin damage

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Quick Facts

Patent No.: US 8,114,422
App. No.: 11/497,870
Granted: Feb 14, 2012
Kind: B2

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Abstract

The Notch signal transduction pathway has been identified as a target for screening and treatment methods for the prevention and/or reduction of short- and long-term UVB-induced skin damage, e.g., the prevention and/or reduction of UVB-induced wrinkles. The invention thus features screening and treatment methods for prevention or reduction of UVB-induced sin damage, and related compositions, e.g., cosmetic compositions.

Claims (25)

1. A method of treating skin damage caused by ultraviolet radiation in a subject, the method comprising:

identifying a subject in need of treatment for skin damage caused by ultraviolet radiation; and

administering to the subject a composition comprising an agent that increases Notch pathway activity for the purpose of treating the identified skin damage, wherein the agent is selected from the group consisting of: AG-370, AG-1296 (6,7-dimethoxy-3-phenylquinoxaline), nigericin•Na, cytochalasin D, FCCP (carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone), and SP600125, thereby treating the skin damage in the subject.

2. The method of claim 1 , wherein the composition is administered topically.

3. The method of claim 1 , wherein the Notch is Notch1.

4. The method of claim 1 , wherein the skin damage is caused by UVB radiation.

5. The method of claim 1 , wherein the skin damage is wrinkles.

6. The method of claim 1 , wherein the agent is AG-370.

7. The method of claim 1 , wherein the agent is AG-1296.

8. The method of claim 1 , wherein the agent is nigericin.Na.

9. The method of claim 1 , wherein the agent is SP600125.

10. A method of protecting against skin damage caused by ultraviolet radiation in a subject, the method comprising:

identifying a subject in need of reduction of skin damage caused by ultraviolet radiation; and

administering to the subject a composition comprising an agent that increases Notch pathway activity for the purpose of reducing skin damage in the subject, wherein the agent is selected from the group consisting of: AG-370, AG-1296 (6,7-dimethoxy-3-phenylquinoxaline), cytochalasin D, FCCP (carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone), and SP600125.

11. The method of claim 10 , wherein the agent is administered topically.

12. The method of claim 10 , wherein the Notch is Notch1.

13. The method of claim 10 , wherein the skin damage is caused by UVB radiation.

14. The method of claim 10 , wherein the skin damage is wrinkles.

15. The method of claim 10 , wherein the agent is AG-370.

16. The method of claim 10 , wherein the agent is AG-1296.

17. The method of claim 10 , wherein the agent is SP600125.

18. The method of claim 1 , wherein the agent is cytochalasin D.

19. The method of claim 1 , wherein the agent is FCCP.

20. The method of claim 10 , wherein the agent is cytochalasin D.

21. The method of claim 10 , wherein the agent is FCCP.

Assignments (5)