Method for banding hard capsules using hydroxypropylmethyl cellulose (HPMC) as a base
View Patent ↗The present invention provides a banding composition for hard capsules using hydroxypropylmethyl cellulose (HPMC) as a base comprising (1) low viscosity HPMC; (2) a component selected from the group consisting of methanol, ethanol, isopropanol, 1-propanol, acetone and/or ethyl acetate; (3) a surfactant; and (4) water; and a method for banding hard capsules using hydroxypropylmethyl cellulose as a base by using the banding composition described.
1. A method for banding a hydroxypropylmethyl cellulose (HPMC) hard capsule having a body and a cap with the inner circumference of said cap at its edge being greater than the outer circumference of the capsule body, said method comprising:
providing said HPMC hard capsule; and
contacting the juncture of the cap and body edge of said HPMC hard capsule with a banding composition, the banding composition comprising:
(1) low viscosity HPMC present in the banding composition in an amount of more than 15% by weight based on the entire weight of the banding composition, the low viscosity HPMC having a viscosity in the form of a 2% aqueous solution of not more than 15 centipoise at 20° C.;
(2) a component selected from the group consisting of methanol, ethanol, isopropanol, 1-propanol, and/or acetone and mixtures of two or more of the foregoing,
(3) a surfactant selected from the group consisting of sorbitan fatty acid esters, sucrose fatty acid esters, polyoxyethylene fatty acid esters, and sodium lauryl sulfate;
(4) water, wherein the proportion of component (2) and water (4) is in a range of from 40:60 to 60:40% by weight;
forming a continuous band locally at the juncture of the cap and body edge of the capsule with the banding composition; and
drying the sealed capsule.
2. The method according to claim 1 , wherein the low viscosity HPMC is present in the banding composition in an amount of more than 20% by weight based on the entire weight of the banding composition.
3. The method according to claim 1 , wherein the component (2) is selected from acetone, ethanol and mixtures thereof.
4. The method according to claim 1 , wherein component (2) is ethanol, the surfactant is sorbitan monolaurate, and the proportion of component (2) and water (4) is 50:50% by weight.
5. The method according to claim 1 , wherein the low viscosity HPMC is a HPMC having a viscosity, in the form of a 2% aqueous solution, of not more than 4.5 centipoise at 20° C.
6. The method according to claim 1 , further comprising distributing the banding composition between overlapping sections of the cap and the body.
7. A method for sealing a hard capsule having a body and a cap, comprising:
contacting a juncture of the body and the cap with a banding composition, the banding composition comprising
(1) low viscosity hydroxypropylmethyl cellulose (HPMC), wherein the low viscosity HPMC has a viscosity of not more than 4.5 centipoise at 20° C. as determined for a 2% aqueous solution and the HPMC is present in the banding composition in an amount of more than 15% by weight based on the entire weight of the banding composition,
(2) a component selected from the group consisting of methanol, ethanol, isopropanol, 1-propanol, acetone and mixtures of two or more of the foregoing, wherein component (2) is in an amount of more than 30% by weight and less than 60% by weight based on the entire weight of the banding composition,
(3) sorbitan monolaurate, and
(4) water, wherein the water is in an amount of more than 30% by weight and less than 60% by weight based on the entire weight of the banding composition, and wherein the proportion of component (2) and water is in a range of from 40:60 to 60:40% by weight; forming a continuous band locally at the juncture of the cap and body edge of the capsule with the banding composition; and
drying the continuous band on the capsule.
8. The method of claim 7 , wherein the contacting is performed at room temperature.
9. The method of claim 7 , wherein the low viscosity HPMC has a viscosity in the form of a 2% aqueous solution of from 3 centipoise to 4.5 centipoise at 20° C.
10. The method of claim 7 , wherein the low viscosity HPMC is present in the banding composition in an amount of from 15% to 24% by weight based on the entire weight of the banding composition.
11. The method of claim 1 , wherein the contacting is carried out at room temperature.
12. The method of claim 1 , wherein the low viscosity HPMC has a viscosity in the form of a 2% aqueous solution of from 3 centipoise to 15 centipoise at 20° C.
13. The method of claim 1 , wherein the low viscosity HPMC has a viscosity in the form of a 2% aqueous solution of from 4.5 centipoise to 15 centipoise at 20° C.
14. The method of claim 1 , wherein the low viscosity HPMC has a viscosity in the form of a 2% aqueous solution of from 6 centipoise to 15 centipoise at 20° C.
15. The method of claim 1 , wherein the low viscosity HPMC is present in the banding composition in an amount of from 15% to 24% by weight based on the entire weight of the banding composition.
16. A method for banding a hydroxypropylmethyl cellulose (HPMC) hard capsule having a body and a cap with the inner circumference of said cap at its edge being greater than the outer circumference of the capsule body, said method comprising:
providing said HPMC hard capsule; and
contacting the juncture of the cap and body edge of said HPMC hard capsule with a banding composition, the banding composition comprising:
(1) low viscosity HPMC present in the banding composition in an amount of more than 15% by weight based on the entire weight of the banding composition, the low viscosity HPMC having a viscosity in the form of a 2% aqueous solution of not more than 15 centipoise at 20° C.;
(2) a component selected from the group consisting of methanol, ethanol, isopropanol, 1-propanol, and/or acetone and mixtures of two or more of the foregoing,
(3) a surfactant selected from the group consisting of sorbitan fatty acid esters, sucrose fatty acid esters, polyoxyethylene fatty acid esters, and sodium lauryl sulfate;
(4) water;
forming a continuous band locally at the juncture of the cap and body edge of the capsule with the banding composition; and
drying the sealed capsule.
17. The method of claim 16 , wherein the contacting is carried out at room temperature.
18. The method of claim 16 , wherein the low viscosity HPMC has a viscosity in the form of a 2% aqueous solution of from 3 centipoise to 15 centipoise at 20° C.
19. The method of claim 16 , wherein the low viscosity HPMC has a viscosity in the form of a 2% aqueous solution of from 4.5 centipoise to 15 centipoise at 20° C.
20. The method of claim 16 , wherein the low viscosity HPMC is present in the banding composition in an amount of from 15% to 24% by weight based on the entire weight of the banding composition.