IP Library › Granted Patent US 7,531,504
Granted Patent B2
US 7,531,504 · App. 11/500,429 · Granted May 12, 2009

Pharmaceutical composition and method for inhibiting gastrointestinal inflammation

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,531,504
App. No.
11/500,429
Granted
May 12, 2009
Kind
B2
Abstract

Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions.

Claims (10)

1. A pharmaceutical composition for treating intestinal inflammation comprising an effective amount of a peptide, the amino acid sequence of the peptide consisting of SEQ ID NO:15.

2. The pharmaceutical composition of claim 1 , wherein the composition is an oral dosage composition.

3. The pharmaceutical composition of claim 2 , wherein the oral dosage composition is formulated for delivery to the small intestine.

4. The pharmaceutical composition of claim 3 , wherein the pharmaceutical composition is a tablet.

5. The pharmaceutical composition of claim 4 , wherein the tablet is gastroresistant.

6. The pharmaceutical composition of claim 3 , wherein the composition is a capsule.

7. The pharmaceutical composition of claim 6 , wherein the capsule is gastroresistant.

8. The pharmaceutical composition of claim 6 , wherein the capsule comprises at least one bead.

9. The pharmaceutical composition of claim 8 , wherein the bead is gastroresistant.

10. A purified peptide consisting of SEQ ID NO: 15.

Assignments (1)
EXECUTIVE ORDER 9424, CONFIRMATORY LICENSE Recorded May 28, 2008
From: UNIVERSITY OF MARYLAND, BALTIMORE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 021010/0528 →