IP Library Granted Patent US 7,563,223
Granted Patent B2
US 7,563,223 · App. 11/500,675 · Granted Jul 21, 2009

Tumescent skin spacing method

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Quick Facts
Patent No.
US 7,563,223
App. No.
11/500,675
Granted
Jul 21, 2009
Kind
B2
Abstract

A method for increasing the distance between outer surface of tissue proximate to a surgical extraction site and a patient's sensitive body tissues comprising the infusion of a solution at a location of minimum distance between the extraction site and the sensitive body tissue until the accumulation of fluid distends the sensitive body tissue away from the extraction site.

Claims (29)

1. A method for increasing the distance between the outer surface of tissue proximate to a surgical extraction site and sensitive body tissue comprising: infusing a solution directly into the tissue at or near a location of minimum distance between said outer surface of the tissue and said sensitive body tissue until the accumulation of fluid distends said sensitive body tissue away from said outer surface of the tissue.

2. The method of claim 1 , wherein said sensitive body tissue is skin.

3. The method of claim 1 , wherein said surgical extraction site is a lumpectomy cavity.

4. The method of claim 1 , wherein said solution contains a polymer that can undergo a gel transition.

5. The method of claim 4 , wherein said polymer is bio-absorbable.

6. The method of claim 4 , wherein said solution further comprises additives to aid in the detection of said gel.

7. The method of claim 1 , wherein said solution contains an anesthetic.

8. A method for increasing the distance between a cavity left by surgical removal of a tumor and a patient's skin comprising:

(a) inserting a device into the subcutaneous region between a cavity left by surgical removal of a tumor and a patient's skin; and

(b) injecting a solution directly into the tissue at or near the location of minimum distance between said cavity and said patient's skin until the accumulation of fluid distends the skin away from said cavity such that a threshold distance between the cavity and the patient's skin is obtained.

9. The method of claim 8 , wherein said threshold distance is greater than 5 millimeters.

10. The method of claim 8 , wherein said tumor is a breast tumor.

11. The method of claim 8 , wherein said solution contains a polymer that can undergo a gel transition.

12. The method of claim 11 , wherein said polymer is bio-absorbable.

13. The method of claim 11 , wherein said solution further comprises additives to aid in the detection of said gel.

14. The method of claim 8 , wherein said solution contains an anesthetic.

15. A method for increasing the distance between a cavity left by surgical removal of a tumor and a patient's skin comprising:

(a) surgically removing at least a portion of a tumor thereby creating a cavity in a patients remaining tissue;

(b) placing an inflatable treatment device in said cavity, said treatment device being connected by a catheter to an injection receptacle;

(c) implanting said injection receptacle subcutaneously;

(d) locating said injection receptacle by imaging the patient's body;

(e) assessing the distance from said injection receptacle to the patient's skin;

(f) inserting a device into the subcutaneous region between a cavity left by surgical removal of a tumor and a patient's skin; and

(g) infusing a solution directly into the tissue at the location of minimum distance between said cavity and said patient's skin until the accumulation of fluid distends the skin away from said cavity such that a threshold distance between the cavity and the patient's skin is obtained.

16. The method of claim 15 , wherein said an inflatable treatment device is a balloon brachytherapy catheter.

17. The method of claim 15 , wherein said solution contains a polymer that can undergo a gel transition.

18. The method of claim 17 , wherein said polymer is bio-absorbable.

19. The method of claim 17 , wherein said solution further comprises additives to aid in the detection of said gel.

20. The method of claim 15 , wherein said solution contains an anesthetic.

Assignments (11)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 26, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024892/0001 →
PATENT SECURITY AGREEMENT Recorded Jul 29, 2008
From: CYTYC CORPORATION
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 021301/0879 →
PATENT SECURITY AGREEMENT Recorded Oct 26, 2007
From: CYTYC CORPORATION
To: GOLDMAN SACHS CREDIT PARTNERS L.P.
Reel/Frame 020018/0529 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 8, 2006
From: SAMPSON, RUSSEL M.
To: CYTEC CORPORATION
Reel/Frame 018168/0325 →