Male anti-fertility agents
Methods and compositions for inhibiting or preventing spermatogenesis in a male mammal. Also disclosed are compounds and formulations for use in such methods.
1 - 42 . (canceled)
43 . A method for inhibiting the ability of a male mammal to conceive progeny, comprising administering to said male mammal, for a period time effective to sufficiently reduce or eliminate spermatozoa in the semen of said male mammal, an effective amount of a compound represented by the following structure:
or a pharmaceutically acceptable salt thereof, wherein:
X 2 is CH or N;
R 2 is H, F, or OCH 3 ;
R 2 * is H or F;
R 8 is H, or lower alkyl of 1 to 6 carbons; and
R 14 is 4-(lower-alkyl)phenyl.
44 . The method of claim 43 , wherein the effective amount of the compound is in a range of between about 0.5 mg/kg of body weight and about 0.001 mg/kg of body weight.
45 . The method of claim 44 , wherein the effective amount of the compound is in a range of between about 0.3 mg/kg of body weight and about 0.005 mg/kg of body weight.
46 . The method of claim 45 , wherein the effective amount of the compound is in a range of between about 0.075 mg/kg of body weight and about 0.01 mg/kg of body weight.
47 . A method for inhibiting the ability of a male mammal to conceive progeny, comprising administering to said male mammal, for a period time effective to sufficiently reduce or eliminate spermatozoa in the semen of said male mammal, an effective amount of a compound represented by the following structure:
or a pharmaceutically acceptable salt thereof.
48 . The method of claim 47 , wherein the effective amount of the compound is in a range of between about 0.5 mg/kg of body weight and about 0.001 mg/kg of body weight.
49 . The method of claim 48 , wherein the effective amount of the compound is in a range of between about 0.3 mg/kg of body weight and about 0.005 mg/kg of body weight.
50 . The method of claim 49 , wherein the effective amount of the compound is in a range of between about 0.075 mg/kg of body weight and about 0.01 mg/kg of body weight.
51 . A method for inhibiting spermatogenesis in a male mammal, comprising administering to said male mammal, over a period of time effective to prevent conception, an effective amount of a compound represented by the following structure:
or a pharmaceutically acceptable salt thereof, wherein:
X 2 is CH or N;
R 2 is H, F, or OCH 3 ;
R 2 * is H or F;
R 8 is H, or lower alkyl of 1 to 6 carbons; and
R 14 is 4-(lower-alkyl)phenyl.
52 . The method of claim 51 , wherein the effective amount of the compound is in a range of between about 0.5 mg/kg of body weight and about 0.001 mg/kg of body weight.
53 . The method of claim 52 , wherein the effective amount of the compound is in a range of between about 0.3 mg/kg of body weight and about 0.005 mg/kg of body weight.
54 . The method of claim 53 , wherein the effective amount of the compound is in a range of between about 0.075 mg/kg of body weight and about 0.01 mg/kg of body weight.
55 . A method for inhibiting spermatogenesis in a male mammal, comprising administering to said male mammal, over a period of time effective to prevent conception, an effective amount of a compound represented by the following structure:
or a pharmaceutically acceptable salt thereof.
56 . The method of claim 55 , wherein the effective amount of the compound is in a range of between about 0.5 mg/kg of body weight and about 0.001 mg/kg of body weight.
57 . The method of claim 56 , wherein the effective amount of the compound is in a range of between about 0.3 mg/kg of body weight and about 0.005 mg/kg of body weight.
58 . The method of claim 57 , wherein the effective amount of the compound is in a range of between about 0.075 mg/kg of body weight and about 0.01 mg/kg of body weight.