Substrate for sensors
It is an object of the present invention to provide a substrate for sensors and a container, wherein the adhesiveness of the substrate to a thin film is improved, a physiologically active substance can be immobilized without the peeling of the thin film from a plastic substrate, and non-specific adsorption during the analysis of interaction among biomolecules is small. The present invention provides a substrate for sensors, which has a thin film layer on a plastic substrate, wherein the plastic substrate has been treated with an organic primer before formation of the thin film.
1 . A substrate for sensors, which has a thin film layer on a plastic substrate, wherein the plastic substrate has been treated with an organic primer before formation of the thin film.
2 . The substrate for sensors according to claim 1 , wherein the treatment with an organic primer is carried out by coating the molded plastic substrate with a primer agent.
3 . The substrate for sensors according to claim 1 , wherein the treatment with an organic primer is carried out by previously mixing a primer agent into a plastic material in an amount of 0.1% by weight to 10% by weight based on the weight of the plastic material, and then molding the mixture into the plastic substrate.
4 . The substrate for sensors according to claim 1 , wherein the organic primer is a compound represented by the formula: R 1 —X—R 2 wherein each of R 1 and R 2 independently represents H or C n H 2n+1 wherein n represents an integer between 1 and 30; and X represents —C(═O)O—, —O—, —C═O—, —N(R)— wherein R represents a hydrogen atom or a lower alkyl group, or —N(R 2 )N(R 1 )— wherein each of R 1 and R 2 independently represents a hydrogen atom or a lower alkyl group.
5 . The substrate for sensors according to claim 4 , wherein n is an integer between 10 and 20.
6 . The substrate for sensors according to claim 1 , wherein the material of the thin film is a metal or a metal oxide.
7 . The substrate for sensors according to claim 6 , wherein the material of the thin film consists of a free electron metal selected from the group consisting of gold, silver, copper, platinum, and aluminum.
8 . The substrate for sensors according to claim 1 , which is a substrate for biosensors.
9 . The substrate for sensors according to claim 1 , which is used in non-electrochemical detection.
10 . The substrate for sensors according to claim 1 , which is used in surface plasmon resonance analysis.
11 . The substrate for sensors according to claim 1 , wherein a linker molecule having a functional group capable of immobilizing a physiologically active substance is bound to the surface of a vacuum formed film layer via a chemical bond.
12 . The substrate for sensors according to claim 1 , wherein a polymer film having a functional group capable of immobilizing a physiologically active substance is formed on the surface of a vacuum formed film layer.
13 . The substrate for sensors according to claim 11 , wherein the functional group capable of immobilizing a physiologically active substance is —OH, —SH, —COOH, —NR 1 R 2 (wherein R 1 and R 2 each independently represents a hydrogen atom or lower alkyl group), —CHO, —NR 3 NR 1 R 2 (wherein each of R 1 , R 2 , and R 3 independently represents a hydrogen atom or lower alkyl group), —NCO, —NCS, an epoxy group, or a vinyl group.
14 . The substrate for sensors according to claim 12 , wherein the functional group capable of immobilizing a physiologically active substance is —OH, —SH, —COOH, —NR 1 R 2 (wherein R 1 and R 2 each independently represents a hydrogen atom or lower alkyl group), —CHO, —NR 3 NR 1 R 2 (wherein each of R 1 , R 2 , and R 3 independently represents a hydrogen atom or lower alkyl group), —NCO, —NCS, an epoxy group, or a vinyl group.
15 . The substrate for sensors according to claim 1 , wherein the plastic substrate is substantially transparent.
16 . The substrate for sensors according to claim 1 , wherein the plastic material that constitutes the substrate is a material having a norbornene skeleton.
17 . The substrate for sensors according to claim 1 , wherein a physiologically active substance is bound to the surface via a covalent bond.
18 . A container having a thin film layer on a plastic substrate, wherein the plastic substrate has been treated with an organic primer before formation of the thin film.