Multiphasic cellular regulation

1. A computer-implemented method comprising:

accepting, in a suitably programmed computing device, input identifying an epithelial target cell population;

accepting, in a suitably programmed computing device, input identifying at least one specified alteration in metabolic activity in at least a part of the epithelial target cell population;

accepting, in a suitably programmed computing device, input identifying at least one specified alteration in telomerase activity in at least a part of the epithelial target cell population;

selecting at least one metabolic-alteration agent in response to the input alteration in metabolic activity in the at least the part of the epithelial target cell population;

selecting at least one telomerase-activity-alteration agent in response to the input alteration in telomerase activity in the at least the part of the epithelial target cell population;

selecting at least one combination of at least one said metabolic-alteration agent and at least one said telomerase-activity-alteration agent, wherein the selected at least one combination is associated with at least one treatment option and is associated with topical administration; and

indicating, in a suitably programmed computing device, the selected at least one combination to at least one system user.

2. The method of claim 1 , wherein said accepting, in a suitably programmed computing device, input identifying an epithelial target cell population comprises:

accepting input identifying at least one melanoma cell, basal cell carcinoma cell, squamous cell carcinoma cell, wart cell, neoplastic cell, dysplastic cell, hyperplastic cell, freckle cell, or non-terminally differentiated cell.

3. The method of claim 1 , wherein said accepting, in a suitably programmed computing device, input identifying an epithelial target cell population comprises:

accepting input identifying a target cell population in situ, ex situ, in vivo, or ex vivo.

4. The method as in claim 1 wherein said accepting, in a suitably programmed computing device, input identifying at least one specified alteration in metabolic activity in at least a part of the epithelial target cell population further comprises:

accepting input identifying mitotic acceleration, mitotic deceleration, increased differentiation, stabilized differentiation, cell growth acceleration, cell growth deceleration, cell cycle progression, or cell cycle stasis.

5. The method as in claim 1 , further comprising:

accepting input identifying one or more cellular features associated with the epithelial target cell population.

6. The method as in claim 5 wherein said accepting input identifying one or more cellular features associated with the epithelial target cell population comprises:

accepting input identifying mitotic index, location, cell size, mass size, mutation, ploidy, or protein expression.

7. The method of claim 1 , further comprising:

selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population.

8. The method of claim 7 , wherein said selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

recalling one or more cellular feature characteristics associated with the epithelial target cell population; and

identifying at least one agent predicted to preferentially alter metabolic activity in response to the one or more cellular feature characteristics associated with the epithelial target cell population.

9. The method as in claim 7 , wherein said selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

identifying at least one agent associated with mitotic acceleration.

10. The method as in claim 7 , wherein said selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

identifying at least one metabolic-alteration agent in response to a desired alteration in metabolic activity related to differentiation, mitosis, cell growth, or cell cycle activity.

11. The method as in claim 7 , wherein said selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

identifying at least one agent that includes all trans retinoic acid in response to a desired alteration in metabolic activity related to mitosis.

12. The method as in claim 7 , wherein said selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

identifying at least one agent associated with a tumor necrosis factor (TNF) alpha related signaling pathway.

13. The method as in claim 7 , wherein said selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

identifying at least one agent associated with a Sonic Hedgehog related signaling pathway.

14. The method as in claim 7 , wherein said selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

identifying at least one agent associated with upregulation of endogenous p53 in at least one epithelial cell.

15. The method of claim 1 , further comprising:

selecting at least one telomerase-activity-alteration agent in response to the specified alteration in telomerase activity in the at least the part of the epithelial target cell population.

16. The method as in claim 15 , wherein said selecting at least one telomerase-activity-alteration agent in response to the specified alteration in telomerase activity in the at least the part of the epithelial target cell population further comprises:

selecting at least one telomerase-activity-alteration agent in response to a desired decrease in telomerase activity, decrease in activity of one or more cellular factors associated with telomerase or decrease in activity of one or more compounds required for telomerase activity.

17. The method as in claim 1 , wherein selecting at least one combination of at least one said metabolic-alteration agent and at least one said telomerase-activity-alteration agent comprises:

selecting at least one combination associated with cell death within the epithelial target cell population.

18. The method as in claim 1 , wherein the selected at least one combination that is associated with a treatment option comprises:

selecting at least one combination associated with substantially simultaneous administration of the at least one metabolic-alteration agent and the at least one telomerase-activity-alteration agent.

19. The method as in claim 1 , wherein the selected at least one combination that is associated with a treatment option comprises:

selecting at least one combination associated with acceptable toxicity.

20. A system comprising:

a recordable type, computer readable medium, bearing:

one or more instructions for accepting input identifying an epithelial target cell population, comprises:

one or more instructions for accepting input identifying at least one specified alteration in metabolic activity in at least a part of the epithelial target cell population,

one or more instructions for accepting input identifying at least one specified alteration in telomerase activity in at least a part of the epithelial target cell population;

one or more instructions for selecting at least one metabolic-alteration agent in response to the input alteration in metabolic activity in the at least the part of the epithelial target cell population;

one or more instructions for selecting at least one telomerase-activity-alteration agent in response to the input alteration in telomerase activity in the at least the part of the epithelial target cell population; and

one or more instructions for selecting at least one combination of at least one said metabolic-alteration agent and at least one said telomerase-activity-alteration agent, wherein the selected at least one combination is associated with at least one treatment option and is associated with topical administration; and

one or more instructions for indicating the selected at least one combination to at least one system user.

21. The system as in claim 20 , wherein said one or more instructions for accepting input identifying an epithelial target cell population comprises:

one or more instructions for accepting input identifying at least one melanoma cell, basal cell carcinoma cell, squamous cell carcinoma cell, wart cell, neoplastic cell, dysplastic cell, hyperplastic cell, freckle cell, or non-terminally differentiated cell.

22. The system as in claim 20 , wherein the one or more instructions for accepting input identifying an epithelial target cell population comprises:

one or more instructions for accepting input identifying an epithelial target cell population in situ, ex situ, in vivo, or ex vivo.

23. The system as in claim 20 , wherein the one or more instructions for accepting input identifying at least one specified alteration in metabolic activity in at least a part of the epithelial target cell population further comprises:

one or more instructions for accepting input identifying mitotic acceleration, mitotic deceleration, increased differentiation, stabilized differentiation, cell growth acceleration, cell growth deceleration, cell cycle progression, or cell cycle stasis.

24. The system as in claim 20 , comprising:

one or more instructions for accepting input identifying one or more cellular features associated with the epithelial target cell population.

25. The system as in claim 24 , wherein the one or more instructions for accepting input identifying one or more cellular features associated with the epithelial target cell population comprises:

one or more instructions for accepting input identifying mitotic index, location, cell size, mass size, mutation, ploidy, or protein expression.

26. The system as in claim 20 , further comprising:

one or more instructions for selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population.

27. The system as in claim 26 wherein said one or more instructions for selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

one or more instructions for recalling one or more cellular feature characteristics associated with the epithelial target cell population; and

one or more instructions for identifying at least one agent predicted to preferentially alter metabolic activity in response to the one or more cellular feature characteristics associated with the epithelial target cell population.

28. The system as in claim 26 wherein said one or more instructions for selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

one or more instructions for identifying at least one agent associated with mitotic acceleration.

29. The system as in claim 26 wherein said one or more instructions for selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

one or more instructions for identifying at least one metabolic-alteration agent in response to a desired alteration in metabolic activity related to differentiation, mitosis, cell growth, or cell cycle activity.

30. The system as in claim 26 wherein said one or more instructions for selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

one or more instructions for identifying at least one agent that includes all trans retinoic acid in response to a desired alteration in metabolic activity related to mitosis.

31. The system as in claim 26 wherein said one or more instructions for selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

one or more instructions for identifying at least one agent associated with a tumor necrosis factor (TNF) alpha related signaling pathway.

32. The system as in claim 26 wherein said one or more instructions for selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

one or more instructions for identifying at least one agent associated with a Sonic Hedgehog related signaling pathway.

33. The system as in claim 26 wherein said one or more instructions for selecting at least one metabolic-alteration agent in response to the specified alteration in metabolic activity in the at least the part of the epithelial target cell population further comprises:

one or more instructions for identifying at least one agent associated with upregulation of endogenous p53 in at least one epithelial cell.

34. The system as in claim 20 further comprising:

one or more instructions for selecting at least one telomerase-activity-alteration agent in response to the specified alteration in telomerase activity in the at least the part of the epithelial target cell population.

35. The system as in claim 34 wherein the one or more instructions for selecting at least one telomerase-activity-alteration agent in response to the specified alteration in telomerase activity in the at least the part of the epithelial target cell population further comprises:

one or more instructions for selecting at least one telomerase-activity-alteration agent in response to a desired decrease in telomerase activity, decrease in activity of one or more cellular factors associated with telomerase or decrease in activity of one or more compounds required for telomerase activity.

36. The system as in claim 20 wherein the one or more instructions for selecting at least one combination of at least one said metabolic-alteration agent and at least one said telomerase-activity-alteration agent comprises:

one or more instructions for selecting at least one combination associated with cell death within the epithelial target cell population.

37. The system as in claim 20 , wherein the selected at least one combination that is associated with a treatment option comprises:

one or more instructions for selecting at least one combination associated with substantially simultaneous administration of the at least one metabolic-alteration agent and the at least one telomerase-activity-alteration agent.

38. The system as in claim 20 , wherein the selected at least one combination that is associated with a treatment option comprises:

one or more instructions for selecting at least one combination associated with acceptable toxicity.

39. A system comprising:

circuitry for accepting input identifying an epithelial target cell population;

circuitry for accepting input identifying at least one specified alteration in metabolic activity in at least a part of the epithelial target cell population; and

circuitry for accepting input identifying at least one specified alteration in telomerase activity in at least a part of the epithelial target cell population;

circuitry for selecting at least one metabolic-alteration agent in response to the input alteration in metabolic activity in the at least the part of the epithelial target cell population;

circuitry for selecting at least one telomerase-activity-alteration agent in response to the input alteration in telomerase activity in the at least the part of the epithelial target cell population;

circuitry for selecting at least one combination of at least one said metabolic-alteration agent and at least one said telomerase-activity-alteration agent, wherein the selected at least one combination is associated with at least one treatment option and is associated with topical administration; and

circuitry for indicating the selected at least one combination to at least one system user.

40. A system comprising:

means for accepting input identifying an epithelial target cell population;

means for accepting input identifying at least one specified alteration in metabolic activity in at least a part of the epithelial target cell population; and

means for accepting input identifying at least one specified alteration in telomerase activity in at least a part of the epithelial target cell population;

means for selecting at least one metabolic-alteration agent in response to the input alteration in metabolic activity in the at least the part of the epithelial target cell population;

means for selecting at least one telomerase-activity-alteration agent in response to the input alteration in telomerase activity in the at least the part of the epithelial target cell population;

means for selecting at least one combination of at least one said metabolic-alteration agent and at least one said telomerase-activity-alteration agent, wherein the selected at least one combination is associated with at least one treatment option and is associated with topical administration; and

means for indicating the selected at least one combination to at least one system user.