IP Library › Granted Patent US 7,556,963
Granted Patent B2
US 7,556,963 · App. 11/514,728 · Granted Jul 7, 2009

Feline IL-18 nucleic acid molecules

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Quick Facts
Patent No.
US 7,556,963
App. No.
11/514,728
Granted
Jul 7, 2009
Kind
B2
Abstract

The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includes feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain nucleic acid molecules encoding such proteins, antibodies raised against such proteins and/or inhibitors of such proteins or nucleic acid molecules. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and/or inhibitors, as well as their use to evaluate and regulate an immune response in an animal.

Claims (20)

1. An isolated nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of:

(a) a nucleic acid sequence encoding the amino acid sequence of SEQ ID NO:2, SEQ ID NO:5, SEQ ID NO:8 or SEQ ID NO:12;

(b) a nucleic acid sequence consisting of SEQ ID NO:73 or SEQ ID NO:74; and

(c) a nucleic acid sequence fully complementary to the nucleic acid sequence of (a) or (b).

2. The isolated nucleic acid molecule of claim 1 , wherein said nucleic acid sequence is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:7,SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:13 and SEQ ID NO:41.

3. A recombinant virus comprising the isolated nucleic acid molecule of claim 1 .

4. A recombinant cell comprising the isolated nucleic acid molecule of claim 1 .

5. A composition comprising an excipient and the isolated nucleic acid molecule of claim 1 .

6. A kit comprising the isolated nucleic acid sequence of claim 1 .

7. An at least 70 nucleotide fragment from an isolated nucleic acid molecule consisting of a nucleic acid sequence selected from the group consisting of:

(a) a nucleic acid sequence encoding the amino acid sequence of SEQ ID NO:2, SEQ ID NO:5, SEQ ID NO:8 or SEQ ID NO:12;

(b) a nucleic acid sequence fully complementary to the nucleic acid sequence of(a).

8. The fragment of claim 7 , wherein said fragment is at least 75 nucleotides in length.

9. The fragment of claim 7 , wherein said fragment is at least 100 nucleotides in length.

10. The fragment of claim 7 , wherein said fragment is at least 200 nucleotides in length.

11. The isolated nucleic acid molecule of claim 7 , wherein said nucleic acid sequence is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:13 and SEQ ID NO:41.

12. A recombinant virus comprising the isolated nucleic acid molecule of claim 7 .

13. A recombinant cell comprising the isolated nucleic acid molecule of claim 7 .

14. A composition comprising an excipient and the isolated nucleic acid molecule of claim 7 .

15. A kit comprising the isolated nucleic acid molecule of claim 7 .