Preventive agent/remedial agent for constipation predominant IBS
View Patent ↗A novel preventive and/or therapeutic medicament for a constipation predominant IBS which contains as the active ingredient a thieno[3,2-b]pyridinecarboxamide derivative represented by the formula (I): wherein R 1 and R 2 each independently represents hydrogen atom or a lower alkyl group and A represents a substituent selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group 1-azabicyclo[2.2.2]octyl group, and the N-oxides thereof, a pharmaceutically acceptable salt thereof, or a solvate or hydrate thereof.
1. A method of treating constipation predominant IBS comprising administering to a patient in need thereof a therapeutically effective amount of a thieno[3,2-b]pyridinecarboxamide derivative represented by the following formula (I) or a tautomer thereof:
wherein R 1 and R 2 each independently represents hydrogen atom or a lower alkyl group and A represents a substituent selected from the group consisting of a 1-azabicyclo[3.2.2]nonyl group, a 1-azabicyclo[2.2.2]octyl group, and N-oxides thereof, or a pharmaceutically acceptable salt thereof.
2. The method according to claim 1 wherein R 1 and R 2 each independently represents a hydrogen atom or a methyl group.
3. The method according to claim 1 , wherein A represents a 1-azabicyclo[2.2.2]oct-3-yl group or an N-oxide thereof.
4. The method according to claim 1 , wherein said derivative is any one of N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide, (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide, (S)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]-pyridine-6-carboxamide, or a tautomer thereof.
5. The method according to claim 1 , wherein said derivative is in the form of a hydrochloride salt.
6. A method of treating constipation predominant IBS comprising administering to a patient in need thereof a therapeutically effective amount of (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide or the tautomer thereof.
7. The method according to claim 2 , wherein A represents a 1-azabicyclo[2.2.2]oct-3-yl group or an N-oxide thereof.
8. The method according to claim 2 , wherein said derivative is in the form of a hydrochloride salt.
9. The method according to claim 3 , wherein said derivative is in the form of a hydrochloride salt.
10. The method according to claim 4 , wherein said derivative is in the form of a hydrochloride salt.
11. The method according to claim 6 , wherein said derivative is in the form of a hydrochloride salt.
12. The method of claim 1 , wherein the derivative of formula (I) is in the form of a pharmaceutically acceptable salt thereof.
13. A method of treating abdominal pain or discomfort associated with constipation predominant IBS, comprising administering to a patient in need thereof a therapeutically effective amount of a thieno[3,2-b]pyridinecarboxamide derivative represented by the following formula (I) or a tautomer thereof:
wherein R 1 and R 2 each independently represents a hydrogen atom or lower alkyl group and A represents a substituent selected from the group consisting of a 1-azabicyclo[3.2.2]nonyl group, a 1-azabicyclo[2.2.2]octyl group and N-oxides thereof, or a pharmaceutically acceptable salt thereof.
14. The method of claim 13 , wherein R 1 and R 2 each independently represents a hydrogen atom or a methyl group.
15. The method of claim 13 , wherein A represents a 1-azabicyclo[2.2.2]oct-3-yl group or an N-oxide thereof.
16. The method of claim 13 , wherein said derivative is any one of N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide, (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide, (S)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide, or a tautomer thereof.
17. The method of claim 13 , wherein said derivative is in the form of a hydrochloride salt.
18. A method of treating abdominal pain or discomfort associated with constipation predominant IBS, comprising administering to a patient in need thereof a therapeutically effective amount of (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide, or the tautomer thereof.
19. The method of claim 18 , wherein said derivative is in the form of a hydrochloride salt.
20. The method of claim 13 , wherein the administration is oral.
21. The method of claim 13 , wherein the derivative of formula (I) is in the form of a pharmaceutically acceptable salt thereof.