Benzothiazole cyclobutyl amine derivatives

1. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein:

m is 0 or 1;

one of R 1 and R 2 is hydrogen, acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, cycloalkyl, fluoroalkoxy, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, alkylthio, —NR A R B , (NR A R B )carbonyl, —SO 2 N(R 14a )(R 14b ), —N(R 14a )SO 2 (R 14b ), a group of the formula —L 2 —R 6 , or a group of the formula —L 3a —R 6a —L 3b —R 6b ;

the other of R 1 and R 2 is selected from the group consisting of hydrogen, cyano, halogen, alkyl, cycloalkyl, fluoroalkyl, alkoxy, alkoxyalkyl, fluoroalkoxy, alkylthio, —SO 2 N(R 14a )(R 14b ), and —N(R 14a )SO 2 (R 14b );

R 3a and R 3b are each independently selected from the group consisting of hydrogen, cyano, halogen, alkyl, cycloalkyl, fluoroalkyl, alkoxy, alkoxyalkyl, fluoroalkoxy, alkylthio, —SO 2 N(R 14a )(R 14b ), and —N(R 14a )SO 2 (R 14b );

R 4 and R 5 are each independently selected from the group consisting of alkyl, fluoroalkyl, hydroxyalkyl, alkoxyalkyl, and cycloalkyl; or R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring;

R 6 is aryl, heterocycle or heterocyclealkyl;

R 6a is aryl or heterocycle;

R 6b is aryl or heterocycle;

L is a bond or alkylene;

L 2 is a bond, —O—, alkylene, —C(═O)—, —S—, —SO 2 N(R 14a )—, N(R 14a )SO 2− —, —C(O)N(R 14a )—, —N(R 14a )C(O)—, or —N(R 15 )—;

L 3a and L 3b are each independently selected from the group consisting of a bond, —O—, alkylene, —C(═O)—, —S—, —SO 2 N(R 14a )—, —N(R 14a )SO 2− —, —C(O)N(R 14a )—, N(R 14a )C(O)—, and —N(R 15 )—;

R 10 is selected from the group consisting of hydrogen, cyano, fluoro, hydroxy, and alkyl;

R 14a and R 14b are each independently selected at each occurrence from the group consisting of hydrogen, alkyl, and cycloalkyl;

R 15 is selected from the group consisting of hydrogen, alkyl, acyl, alkoxycarbonyl, and (R 14a )(R 14b )NC(O)—; and

R A and R B are independently selected from hydrogen, alkyl, acyl, haloalkyl, alkoxycarbonyl, cycloalkyl, and formyl.

2. The compound of claim 1 , wherein R 1 is —L 2 —R 6 , wherein L 2 is a bond and R 6 is as defined in claim 1 .

3. The compound of claim 2 , wherein R 6 is a heterocycle which may be unsubstituted, or alternatively may be optionally substituted with one or more substituents chosen from the list of acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, cycloalkyl, fluoroalkoxy, formyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, oxo, alkylthio, —NR A R B , (NR A R B )carbonyl, —SO 2 N(R 14a )(R 14b ), and —N(R 14a )SO 2 (R 14b ).

4. The compound of claim 3 , wherein R 6 is selected from the group consisting of furyl, imidazolyl, isoxazolyl, isothiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl, tetrazolyl, thiadiazolyl, thiadiazolonyl, thiadiazinonyl, oxadiazolyl, oxadiazolonyl, oxadiazinonyl, thiazolyl, thienyl, triazinyl, triazolyl, triazolyl, pyridazinonyl, pyridonyl, pyrimidinonyl, indolyl, benzothienyl, benzofuranyl, indazolyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, benzoisothiazolyl, benzoisoxazolyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pteridinyl, purinyl, naphthyridinyl, cinnolinyl, thieno[2,3-d]imidazole, pyrrolopyrimidinyl, azepanyl, azetidinyl, aziridinyl, azocanyl, morpholinyl, piperazinyl, piperidinyl, pyrrolidinyl, pyrrolinyl, dihydrothiazolyl, dihydropyridinyl, thiomorpholinyl, dioxanyl, dithianyl, tetrahydrofuryl, dihydropyranyl, tetrahydropyranyl, and [1,3]dioxolanyl.

5. The compound of claim 4 , wherein R 6 is selected from the group consisting of cyanophenyl, pyrazolyl, pyrimidinyl, pyrimidinonyl, pyridinyl, pyridazinonyl, and quinolinyl, wherein each ring is substituted with 0, 1, or 2 substituents selected from methoxy and methyl.

6. The compound of claim 1 , wherein R 3a and R 3b are both hydrogen.

7. The compound of claim 1 , wherein R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring, wherein the non-aromatic ring is a 4- to 9-membered non-aromatic ring.

8. The compound of claim 7 , wherein the non-aromatic ring is a ring of the structure:

Q 1 is O, S, —N(R 20 )—, or C;

Q 2 is —N(R 20 )— or C;

Q 3 is N or C;

R 20 is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl;

p1 and p2 are each independently 1, 2 or 3;

q1, q2, q3, q4, and q5 are each independently 0, 1, or 2; and

r1, r2 and r3 are each independently 1 or 2;

wherein each carbon atom in the ring is substituted with hydrogen, or with 0, 1, or 2 substituents independently selected at each occurrence from the group consisting of hydrogen, hydroxy, fluoro, alkyl, hydroxyalkyl, fluoroalkyl, cycloalkyl, cyano, fluoroalkoxy, alkoxyalkyl, alkoxy, fluoroalkoxy, haloalkyl, and N(R 21a )(R 21b ), wherein R 21a and R 21b are each independently selected from the group consisting of hydrogen, alkyl, and alkylcarbonyl.

9. The compound of claim 1 , wherein R 4 and R 5 are taken together with the nitrogen atom to which each is attached to form azepanyl, azetidinyl, aziridinyl, azocanyl, morpholinyl, piperazinyl, piperidinyl, pyrrolidinyl, pyrrolinyl, and hexahydropyrrolo[3,4-b]pyrrolyl, wherein each group is substituted with 0, 1, or 2 substituents selected from alkyl, hydroxyalkyl, and fluoro.

10. The compound of claim 1 , where m is 0, L is a bond, and R 6 is heterocycle.

11. The compound of claim 1 , wherein the compound has the formula (II):

wherein R 1 , R 2 , R 3a , R 3b , R 4 , and R 5 are as defined in claim 1 .

12. The compound of claim 1 , wherein the compound has the formula (III):

wherein R 1 , R 2 , R 3a , R 3b , R 4 , and R 5 are as defined in claim 1 .

13. The compound of claim 1 , wherein one of R 1 and R 2 is L 2 R 6 , L 2 is a bond, and R 6 is a structure of formula:

wherein R 16 and R 17 each are independently selected from hydrogen, alkyl, haloalkyl, cycloalkyl, alkoxyalkyl, aryl, and heteroaryl; or R 16 and R 17 taken together with the carbon atom to which each is attached form a 3- to 7-membered ring; v is 1, 2, 3, 4, 5, or 6.

14. The compound of claim 1 , selected from the group consisting of:

Trans-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-6-(2,6-dimethylpyridin-3-yl)-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-6-(2,4-dimethoxypyrimidin-5-yl)-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-6-(2-methoxypyrimidin-5-yl)-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-6-pyridin-4-yl-1,3-benzothiazole;

Trans-6-(6-methoxypyridin-3-yl)-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-6-pyridin-3-yl-1,3-benzothiazole;

Trans-3-(2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)quinoline;

Trans-6-(6-fluoropyridin-3-yl)-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-4-(2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)benzonitrile;

Trans-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-6-(2,4-dimethoxypyrimidin-5-yl)-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-6-(2,6-dimethylpyridin-3-yl)-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-6-(2-methoxypyrimidin-5-yl)-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-6-(6-methoxypyridin-3-yl)-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-3-(2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)quinoline;

Cis-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-6-pyrimidin-5-yl-1,3-benzothiazole;

Cis-6-(2,6-dimethylpyridin-3-yl)-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Cis-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-6-pyrimidin-5-yl-1,3-benzothiazole;

Cis-6-(2,4-dimethoxypyrimidin-5-yl)-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Cis-6-(2,6-dimethylpyridin-3-yl)-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-2-(2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridazin-3(2H)-one;

Trans-6-methyl-2-(2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridazin-3(2H)-one;

Trans-5-methyl-1-(2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridin-2(1H)-one;

Trans-3-methyl-1-(2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridin-2(1H)-one;

Trans-2-(2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridazin-3(2H)-one;

Trans-6-methyl-2-(2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridazin-3(2H)-one;

Trans-5-methyl-1-(2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridin-2(1H)-one;

Trans-3-methyl-1-(2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridin-2(1H)-one;

Cis-6-pyrimidin-5-yl-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Cis-6-(2-methoxypyrimidin-5-yl)-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Cis-2-(3-piperidin-1-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole

Cis-6-(2-methoxypyrimidin-5-yl)-2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazole;

Cis-2-(3-azepan-1-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole;

Cis-2-(3-morpholin-4-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole;

Cis-{(2S)-1-[3-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)cyclobutyl]pyrrolidin-2-yl}methanol;

Cis-((2S)-1-{3-[6-(2-methoxypyrimidin-5-yl)-1,3-benzothiazol-2-yl]cyclobutyl}pyrrolidin-2-yl)methanol;

Cis-2-{3-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]cyclobutyl}-6-pyrimidin-5-yl-1,3-benzothiazole;

Cis-2-{3-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]cyclobutyl}-6-(2-methoxypyrimidin-5-yl)-1,3-benzothiazole;

Cis-2-{3-[(2R)-2-methylpiperidin-1-yl]cyclobutyl}-6-pyrimidin-5-yl-1,3-benzothiazole;

Cis-N-isopropyl-N-methyl-N-[3-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)cyclobutyl]amine;

Cis-{1-[3-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)cyclobutyl]piperidin-4-yl}methanol;

Trans-{1-[3-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)cyclobutyl]piperidin-4-yl}methanol;

Trans-2-(3-piperidin-1-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-6-(2,6-dimethylpyridin-3-yl)-2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-6-(6-methoxypyridin-3-yl)-2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-6-(2-methoxypyrimidin-5-yl)-2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one;

Cis-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one;

Trans-6-methyl-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one;

Trans-3-methyl-1-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridin-2(1H)-one;

Trans-6-(1-methyl-1H-pyrazol-4-yl)-2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-N-isopropyl-N-methyl-N-[3-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)cyclobutyl]amine;

Trans-N-isopropyl-N-{3-[6-(2-methoxypyrimidin-5-yl)-1,3-benzothiazol-2-yl]cyclobutyl}-N-methylamine;

Trans-N-isopropyl-N-{3-[6-6-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]cyclobutyl}-N-methylamine;

Trans-N-isopropyl-N-{3-[6-(2-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]cyclobutyl}-N-methylamine;

Trans-N-{3-[6-(2,6-dimethylpyridin-3-yl)-1,3-benzothiazol-2-yl]cyclobutyl}-N-isopropyl-N-methylamine;

Trans-2-(2-{3-[isopropyl(methyl)amino]cyclobutyl}-1,3-benzothiazol-6-yl)pyridazin-3(2H)-one;

Trans-2-(2-{3-[isopropyl(methyl)amino]cyclobutyl}-1,3-benzothiazol-6-yl)-6-methylpyridazin-3(2H)-one;

Trans-1-(2-{3-[isopropyl(methyl)amino]cyclobutyl}-1,3-benzothiazol-6-yl)-3-methylpyridin-2(1H)-one;

Trans-1-(2-{3-[isopropyl(methyl)amino]cyclobutyl}-1,3-benzothiazol-6-yl)-5-methylpyridin-2(1H)-one;

Trans-2-(3-azetidin-1-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-6-pyrimidin-5-yl-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-6-(2,6-dimethylpyridin-3-yl)-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-6-(2-methoxypyrimidin-5-yl)-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-6-(2,4-dimethoxypyrimidin-5-yl)-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-6-(6-methoxypyridin-3-yl)-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-2-[2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one;

Trans-6-methyl-2-[2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one;

Trans-5-methyl-1-[2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridin-2(1H)-one;

Trans-3-methyl-1-[2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridin-2(1H)-one;

Trans-2-(3-azepan-1-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-2-(3-morpholin-4-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-2-{3-[(2S)-2-(fluoromethyl)pyrrolidin-1-yl]cyclobutyl}-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-{(2S)-1-[3-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)cyclobutyl]pyrrolidin-2-yl}methanol;

Trans-((2S)-1-{3-[6-(2,6-dimethylpyridin-3-yl)-1,3-benzothiazol-2-yl]cyclobutyl}pyrrolidin-2-yl)methanol;

Trans-2-[3-(2-methylpiperidin-1-yl)cyclobutyl]-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-2-(3-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-2-[3-(4-fluoropiperidin-1-yl)cyclobutyl]-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-2-[3-(4-fluoropiperidin-1-yl)cyclobutyl]-6-(2-methoxypyrimidin-5-yl)-1,3-benzothiazole;

Trans-6-(2,6-dimethylpyridin-3-yl)-2-[3-(4-fluoropiperidin-1-yl)cyclobutyl]-1,3-benzothiazole;

Trans-(3R)-1-[3-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)cyclobutyl]piperidin-3-ol;

Trans-N-ethyl-N-propyl-N-[3-(6-pyrimidin-5-yl-1,3-benzothiazol-2-yl)cyclobutyl]amine;

Trans-Diethyl-[3-(6-pyrimidin-5-yl-benzothiazol-2-yl)-cyclobutyl]-amine;

Trans-Diethyl-{3-[6-(2-methoxy-pyrimidin-5-yl)-benzothiazol-2-yl]-cyclobutyl}-amine;

Trans-{3-[6-(2-Methoxy-pyrimidin-5-yl)-benzothiazol-2-yl]-cyclobutyl}-methyl-propyl-amine;

Trans-{3-[6-(2,6-Dimethyl-pyridin-3-yl)-benzothiazol-2-yl]-cyclobutyl}-methyl-propyl-amine;

Trans-Methyl-{3-[6-(1-methyl-1H-pyrazol-4-yl)-benzothiazol-2-yl]-cyclobutyl}-propyl-amine;

Trans-2-(Ethyl-{3-[6-(2-methoxy-pyrimidin-5-yl)-benzothiazol-2-yl]-cyclobutyl}-amino)-ethanol;

Trans-2-({3-[6-(2,6-Dimethyl-pyridin-3-yl)-benzothiazol-2-yl]-cyclobutyl}-ethyl-amino)-ethanol;

6-Pyrimidin-5-yl-2-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-benzothiazole;

Trans-5-(2,6-Dimethyl-pyridin-3-yl)-2-[3-(2-methyl-pyrrolidin-1-yl)-cyclobutyl]-benzothiazole;

Trans-5-(2,4-Dimethoxy-pyrimidin-5-yl)-2-[3-(2-methyl-pyrrolidin-1-yl)-cyclobutyl]-benzothiazole;

Trans-6-(1-Methyl-1H-pyrazol-4-yl)-2-[3-(2-methyl-pyrrolidin-1-yl)-cyclobutyl]-benzothiazole;

Trans-2-[3-(4-Fluoro-piperidin-1-yl)-cyclobutyl]-6-(1-methyl-1H-pyrazol-4-yl)-benzothiazole;

Trans-2-(3-azetidin-1-ylcyclobutyl)-6-(2-methoxypyrimidin-5-yl)-1,3-benzothiazole;

Trans-2-(3-azetidin-1-ylcyclobutyl)-6-(2,6-dimethylpyridin-3-yl)-1,3-benzothiazole;

Trans-2-(3-azetidin-1-ylcyclobutyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,3-benzothiazole;

Trans-2-(3-azepan-1-ylcyclobutyl)-6-(2-methoxypyrimidin-5-yl)-1,3-benzothiazole;

Trans-2-(3-azepan-1-ylcyclobutyl)-6-(2,6-dimethylpyridin-3-yl)-1,3-benzothiazole;

Trans-2-(3-azepan-1-ylcyclobutyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,3-benzothiazole;

Cis-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-acetamide;

Cis-2-Chloro-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-acetamide;

Cis-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-propionamide;

Cis-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-isobutyramide;

Cis-Cyclopropanecarboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-Cyclobutanecarboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-Cyclopentanecarboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-Cyclohexanecarboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-Furan-2-carboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-4-Cyano-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-benzamide;

Cis-4-Cyano-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-benzenesulfonamide;

Cis-Thiophene-2-sulfonic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-Thiophene-2-carboxylic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-Thiophene-2-carboxylic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-carbamic acid isobutyl ester;

Cis-Morpholine-4-carboxylic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-Pyrazine-2-carboxylic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Cis-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-2-thiophen-3-yl-acetamide;

Cis-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-3-thiophen-2-yl-propionamide;

Cis-3-Furan-2-yl-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-propionamide;

Cis-Pyrimidine-5-carboxylic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Trans-4-Cyano-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-benzamide;

Trans-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-propionamide;

Trans-N-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-isobutyramide;

Trans-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-carbamic acid isobutyl ester;

Trans-Cyclopropanecarboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Trans-Cyclobutanecarboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Trans-Cyclopentanecarboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Trans-Cyclohexanecarboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Trans-Fu ran-2-carboxylic acid[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Trans-Morpholine-4-carboxylic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Trans-Pyrimidine-5-carboxylic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Trans-Pyrazine-2-carboxylic acid-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amide;

Racemic-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-pyrimidin-5-yl-amine;

Racemic-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-pyrimidin-2-yl-amine;

Racemic-(5-bromo-pyrimidin-2-yl)-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amine;

Racemic-(5-methyl-pyridin-2-yl)-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-yl]-amine;

Racemic-6-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-ylamino]-nicotinonitrile;

Racemic-6-[2-(3-Piperidin-1-yl-cyclobutyl)-benzothiazole-6-ylamino]-nicotinonitrile;

2-{Trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl-azetidin-2-one;

2-{Trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl-pyrrolidin-2-one;

2-{Trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl-piperidin-2-one;

2-{Trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl-homopyrrolidin-2-one;

2-{Trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-carboxamide;

N-Isopropyl-2-{trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-carboxamide;

N-cyclopropyl-2-{trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-carboxamide;

N-phenyl-2-{trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-carboxamide;

N-thiazol-2-yl-2-{trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-carboxamide;

N-benzyl-2-{trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-carboxamide;

N-(2-phenethyl)-2-{trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-carboxamide;

N,N-dimethyl-2-{trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-carboxamide;

(Pyrrolidin-1-yl)-2-{trans-3-[(S)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole-6-methanone;

2-[Trans-3-(piperidin-1-yl)cyclobutyl]-1,3-benzothiazol-6-yl-3-methyl-pyrrolidin-2-one;

2-[Trans-3-(piperidin-1-yl)cyclobutyl]-1,3-benzothiazol-6-yl-oxazolidin-2-one;

2-[Trans-3-(piperidin-1-yl)cyclobutyl]-1,3-benzothiazol-6-yl-3-methylimidazolidin-2-one;

Trans-6-bromo-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Trans-6-bromo-2-{3-[(2S)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Cis 6-bromo-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Cis-6-bromo-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Cis-6-bromo-2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazole;

Cis-2-(3-azepan-1-ylcyclobutyl)-6-bromo-1,3-benzothiazole;

Cis-{(2S)-1-[3-(6-bromo-1,3-benzothiazol-2-yl)cyclobutyl]pyrrolidin-2-yl}methanol;

Cis-tert-butyl(3aR,6aR)-5-[3-(6-bromo-1,3-benzothiazol-2-yl)cyclobutyl]hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate;

Cis-6-bromo-2-{3-[(2R)-2-methylpiperidin-1-yl]cyclobutyl}-1,3-benzothiazole;

Cis-N-[3-(6-bromo-1,3-benzothiazol-2-yl)cyclobutyl]-N-isopropyl-N-methylamine;

Cis-{1-[3-(6-bromo-1,3-benzothiazol-2-yl)cyclobutyl]piperidin-4-yl}methanol;

Trans-{1-[3-(6-bromo-1,3-benzothiazol-2-yl)cyclobutyl]piperidin-4-yl}methanol;

Trans-6-bromo-2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-N-[3-(6-bromo-1,3-benzothiazol-2-yl)cyclobutyl]-N-isopropyl-N-methylamine;

Trans-2-(3-azetidin-1-ylcyclobutyl)-6-bromo-1,3-benzothiazole;

Trans-6-bromo-2-(3-pyrrolidin-1-ylcyclobutyl)-1,3-benzothiazole;

Trans-2-(3-azepan-1-ylcyclobutyl)-6-bromo-1,3-benzothiazole;

Trans-6-bromo-2-(3-morpholin-4-ylcyclobutyl)-1,3-benzothiazole;

Trans-6-bromo-2-{3-[(2S)-2-(fluoromethyl)pyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol;

Trans-{(2S)-1-[3-(6-bromo-1,3-benzothiazol-2-yl)cyclobutyl]pyrrolidin-2-yl}methanol;

Trans-6-bromo-2-[3-(2-methylpiperidin-1-yl)cyclobutyl]-1,3-benzothiazole;

Trans-tert-butyl 5-[3-(6-bromo-1,3-benzothiazol-2-yl)cyclobutyl]hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate;

Trans-6-bromo-2-[3-(4-fluoropiperidin-1-yl)cyclobutyl]-1,3-benzothiazole;

Trans-[3-(6-Bromo-benzothiazol-2-yl)-cyclobutyl]-diethyl-amine;

Trans-[3-(6-Bromo-benzothiazol-2-yl)-cyclobutyl]-methyl-propyl-amine;

Trans-2-{[3-(6-Bromo-benzothiazol-2-yl)-cyclobutyl]-ethyl-amino}-ethanol;

6-Bromo-2-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-benzothiazole; and

Trans-5-Chloro-2-[3-(2-methyl-pyrrolidin-1-yl)-cyclobutyl]-benzothiazole.

15. The compound of claim 1 , selected from the group consisting of:

Trans-2-(3-piperidin-1-ylcyclobutyl)-6-pyrimidin-5-yl-1,3-benzothiazole;

Trans-Diethyl-{3-[6-(2-methoxy-pyrimidin-5-yl)-benzothiazol-2-yl]-cyclobutyl}-amine; and

Trans-2-(Ethyl-{3-[6-(2-methoxy-pyrimidin-5-yl)-benzothiazol-2-yl]-cyclobutyl}-amino)-ethanol;

Trans-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one; and

Cis-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one.

16. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier.

17. A compound that is trans-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one or a pharmaceutically acceptable salt thereof.

18. A compound that is cis-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one or a pharmaceutically acceptable salt thereof.