Methods and compositions for treating polycystic ovary syndrome
View Patent ↗The present invention relates to methods of treating polycystic ovary syndrome (PCOS) comprising administering glucagon-like peptide-1 (GLP-1), exendin, and analogs and agonists thereof, to subjects suffering therefrom.
1. A method for treating polycystic ovary syndrome in a patient in need thereof comprising administering to the patient a therapeutically effective amount of
(i) an exendin-4 comprising the amino acid sequence of SEQ ID NO:9, and
(ii) metformin,
to treat the polycystic ovary syndrome in the patient.
2. The method of claim 1 , wherein the method reduces insulin resistance in the patient.
3. The method of claim 1 , wherein the method prevents the onset of type-2 diabetes in the patient.
4. The method of claim 1 , wherein the method restores regular menses in the patient.
5. The method of claim 1 , wherein the method restores regular ovulation in the patient.
6. The method of claim 1 , wherein the method restores fertility in the patient.
7. The method of claim 1 , wherein the method prevents spontaneous abortion in the patient.
8. A method for treating irregular menses in a patient diagnosed with polycystic ovary syndrome comprising administering to the patient a therapeutically effective amount of
(i) an exendin-4 comprising the amino acid sequence of SEQ ID NO:9, and
(ii) metformin,
to treat irregular menses in the patient.
9. A method for treating infertility in a patient diagnosed with polycystic ovary syndrome comprising administering to the patient a therapeutically effective amount of
(i) an exendin-4 comprising the amino acid sequence of SEQ ID NO:9, and
(ii) metformin,
to treat the infertility in the patient.
10. The method of claim 9 , wherein the method for treating infertility restores regular ovulation in the patient.