IP Library › Granted Patent US 7,538,125
Granted Patent B2
US 7,538,125 · App. 11/523,771 · Granted May 26, 2009

Pharmaceutical composition

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Quick Facts
Patent No.
US 7,538,125
App. No.
11/523,771
Granted
May 26, 2009
Kind
B2
Abstract

Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

Claims (21)

1. A pharmaceutical composition which comprises:

1) pioglitazone or a pharmacologically acceptable salt thereof;

2) glimepiride; and

3) a physiologically acceptable carrier.

2. The pharmaceutical composition according to claim 1 , which is in an oral dosage form.

3. The pharmaceutical composition according to claim 1 , which is in the form of a tablet.

4. The pharmaceutical composition according to claim 1 , which comprises pioglitazone or a pharmacologically acceptable salt thereof at the oral dose range from 0.05 to 5 mg/kg body weight.

5. The pharmaceutical composition according to claim 1 , which is for administration at the frequency of 1 to 3 times a day.

6. The pharmaceutical composition according to claim 1 , which comprises:

1) pioglitazone or a pharmacologically acceptable salt thereof;

2) glimepiride;

3) an excipient;

4) a disintegrator;

5) a binder; and

6) a lubricant.

7. The pharmaceutical composition according to claim 6 , wherein the excipient is lactose.

8. The pharmaceutical composition according to claim 6 , wherein the binder is hydroxypropylcellulose.

9. The pharmaceutical composition according to claim 6 , wherein the lubricant is magnesium stearate.

10. The pharmaceutical composition according to claim 6 , which is manufactured by

adding the excipient, the disintegrator, the binder and the lubricant to pioglitazone or a pharmacologically acceptable salt thereof and glimepiride; and then

compressing the resultant.