IP Library Granted Patent US 8,227,471
Granted Patent B2
US 8,227,471 · App. 11/524,268 · Granted Jul 24, 2012

Treating sexual desire disorders with flibanserin

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,227,471
App. No.
11/524,268
Granted
Jul 24, 2012
Kind
B2
Abstract

The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire.

Claims (24)

1. A method of treating a patient having hypoactive sexual desire disorder, comprising administering a therapeutically effective amount of flibanserin or a pharmaceutically acceptable acid addition salt thereof to the patient to treat hypoactive sexual desire disorder.

2. The method of claim 1 , wherein the patient is male.

3. The method of claim 1 , wherein the amount administered is between 0.1 and 400 mg per day of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

4. The method of claim 1 , wherein the amount administered is between 1 and 300 mg per day of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

5. The method of claim 1 , wherein the amount administered is between 2 and 200 mg per day of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

6. The method of claim 1 , wherein the amount administered is in a dosage unit containing from 0.01 to 100 mg of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

7. The method of claim 1 , wherein the amount administered is in a dosage unit containing from 0.1 to 50 mg of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

8. The method of claim 1 wherein the amount administered is in a dosage unit containing 150 mg of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

9. The method of claim 1 , wherein the amount administered is in a dosage unit containing 100 mg of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

10. The method of claim 1 , wherein the amount administered is in a dosage unit containing 80 mg of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

11. The method of claim 1 , wherein the amount administered is in a dosage unit containing 50 mg of flibanserin or a pharmaceutically acceptable acid addition salt thereof.

12. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof selected from the salts formed by the acids selected from the group consisting of succinic acid, hydrobromic acid, acetic acid, fumaric acid, maleic acid, methanesulphonic acid, lactic acid, phosphoric acid, hydrochloric acid, sulphuric acid, tartaric acid, citric acid, and mixtures thereof.

13. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with succinic acid.

14. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with hydrobromic acid.

15. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with acetic acid.

16. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with fumaric acid.

17. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with maleic acid.

18. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with methanesulphonic acid.

19. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with lactic acid.

20. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with phosphoric acid.

21. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with hydrochloric acid.

22. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with sulphuric acid.

23. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with tartaric acid.

24. A method according to claim 1 , wherein flibanserin is administered in the form of a pharmaceutically acceptable acid addition salt thereof, wherein the salt is formed with citric acid.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2025
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED); SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD; SANTARUS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; HUMAX PHARMACEUTICAL S.A.; SOLTA MEDICAL IRELAND LIMITED; BAUSCH & LOMB MEXICO, S.A. DE C.V.; BAUSCH+LOMB OPS B.V.; BAUSCH HEALTH AMERICAS, INC.; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH HOLDCO LIMITED; BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC); BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA); BAUSCH HEALTH US, LLC; BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC.; ICN POLFA RZESZOW SPOLKA AKCYJNA (A/K/A ICN POLFA RZESZOW S.A.); ORAPHARMA, INC.; PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.); SOLTA MEDICAL DUTCH HOLDINGS B.V.; V-BAC HOLDING CORP.; VRX HOLDCO LLC; 1261229 B.C. LTD.; 1530065 B.C. LTD.
Reel/Frame 070778/0199 →
RELEASE OF SECURITY INTEREST IN SPECIFIED PATENTS Recorded Sep 9, 2022
From: THE BANK OF NEW YORK MELLON
To: SPROUT PHARMACEUTICALS, INC.
Reel/Frame 061402/0236 →
RELEASE OF SECURITY INTEREST IN SPECIFIED PATENTS Recorded Sep 9, 2022
From: BARCLAYS BANK PLC
To: SPROUT PHARMACEUTICALS, INC.
Reel/Frame 061402/0194 →
SECURITY INTEREST Recorded Feb 25, 2021
From: SPROUT PHARMACEUTICALS, INC.
To: GOODRICH, BRAXTON; WHITEHEAD, ROBERT
Reel/Frame 055407/0810 →
SECURITY INTEREST Recorded Jul 19, 2017
From: SPROUT PHARMACEUTICALS, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 043041/0950 →
SECURITY AGREEMENT Recorded Dec 21, 2015
From: SPROUT PHARMACEUTICALS, INC., AS GRANTOR; UNILENS VISION INC., AS GRANTOR; COMMONWEALTH LABORATORIES, LLC, AS GRANTOR; SYNERGETICS USA, INC., AS GRANTOR
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 037357/0490 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2012
From: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
To: SPROUT PHARMACEUTICALS, INC.
Reel/Frame 027527/0168 →