Cocrystallization methods
Methods for preparing cocrystals wherein solutions of active agents in suitable liquids are combined with solutions of guests, both with and without suitable liquids, in an interface region are described herein. Methods for analyzing the cocrystals are also described.
1 . A method for screening a cocrystal of an active agent and a guest comprising the steps of:
a. Contacting the active agent with a suitable liquid to form an active-agent solution;
b. Contacting the active-agent solution with a guest solution to form a mixture of solutions in an interface region;
c. Solidifying the solution mixture in the interface region to form a solid;
d. Analyzing the solid for the presence of a cocrystal.
2 . The method of claim 1 wherein the analysis is performed by observing the formation of eutectic regions on both sides of the cocrystal in the interface region.
3 . The method of claim 1 wherein the solidification occurs by lowering the temperature of the interface region mixture.
4 . The method of claim 1 wherein the guest solution is a melt of the guest.
5 . The method of claim 1 wherein the guest solution is prepared by contacting the guest with a suitable liquid.
6 . The method of claim 5 wherein the suitable liquid contacted with the active agent is the same as that which is contacted with the guest.
7 . The method of claims 1 , 5 , or 6 wherein the suitable liquid has a higher boiling point than the melting point of the active agent.
8 . The method of claims 5 or 6 wherein the suitable liquid has a higher boiling point that the melting point of the guest.
9 . The method of claim 1 wherein the analytical technique is selected from optical microscopy, x-ray powder diffraction, single-crystal x-ray analysis, Raman spectroscopy, Raman microscopy, and infrared spectroscopy.
10 . A method for preparing a cocrystal of an active agent and a guest comprising the steps of:
a. Contacting the active agent with a suitable liquid to form an active-agent solution;
b. Contacting the active-agent solution with a guest solution to form a mixture of solutions in an interface region;
c. Solidifying the solution mixture in the interface region to form a cocrystal.