IP Library › Patent Application 11531931
Patent Application
App. No. 11/531,931

METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29

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Quick Facts
Patent No.
US None
App. No.
11/531,931
Abstract

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

Claims (5)

1 . A method of treating a viral infection comprising administering to an immunocompromised mammal with a hepatitis infection a therapeutically effective amount of a polypeptide comprising the amino acid sequence of SEQ ID NO:20, wherein after administration of the polypeptide the hepatitis infection is reduced.

2 . The method of claim 1 wherein the polypeptide is conjugated to a polyalkyl oxide moiety.

3 . The method of claim 2 wherein the polyalkyl oxide moiety is a polyethylene glycol.

4 . The method of claim 1 wherein the hepatitis infection is a hepatitis B infection.

5 . The method of claim 1 wherein the hepatitis infection is a hepatitis C infection.