IP Library › Granted Patent US 7,674,616
Granted Patent B2
US 7,674,616 · App. 11/532,072 · Granted Mar 9, 2010

Device and method for measuring properties of a sample

Assignee: Hemosense, Inc.
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Quick Facts
Patent No.
US 7,674,616
App. No.
11/532,072
Granted
Mar 9, 2010
Kind
B2
Abstract

Test strips designed to prevent or reduce false results when measuring the condition of a sample are provided. The test strips can be used for analysis of samples by methods including electrical and optical measurements. The reagent test strips and methods are particularly suited for use in the detection of blood coagulation.

Claims (14)

1. A test strip for determining the degree of the ability of a sample to coagulate comprising at least two branch channels each fluidly connected to a different reaction chamber, wherein at least one of said branch channels is a delaying branch channel and at least one of said branch channels is a non-delaying branch channel, wherein the delaying branch channel is adapted to delay arrival of a portion of the sample to its reaction chamber with respect to arrival of a second portion of the sample to said non-delaying branch channel reaction chamber, and further wherein at least one of said delaying branch channels is fluidly connected to a control reaction chamber, wherein at least one of said non-delaying branch channels is fluidly connected to an assay reaction chamber, and wherein the control reaction chamber comprises an electrode pair for measuring an electrical property of the sample.

2. The test strip of claim 1 , wherein the reaction chamber of the delaying channel detects an error in the test strip.

3. The test strip of claim 1 , wherein said delaying branch channel is longer than said non-delaying branch channel.

4. The test strip of claim 1 , wherein said delaying branch channel is narrower than said non-delaying branch channel.

5. The test strip of claim 1 , wherein said delaying branch channel is longer and narrower than said non-delaying branch channel.

6. The test strip of claim 1 , wherein said delaying branch channel is partially occluded by an obstacle.

7. The test strip of claim 6 , wherein said obstacle is less wettable than said branch channel.

8. The test strip of claim 1 , wherein said reaction chambers are configured for the detection of coagulation or lysis time of a fluid sample.

9. The test strip of claim 1 , wherein said delaying branch channel prolongs the time it takes a sample to fill a reaction chamber coupled to said delaying branch channel.

10. The test strip of claim 1 , wherein at least one reaction chamber of said non-delaying branch channel comprises a reagent that activates the coagulation of said fluid sample for determining one of prothrombin time (PT), activated clotting time (ACT), activated partial prothrombin time (APTT), or thrombin clotting time (TCT).

11. The test strip of claim 1 , wherein at least one reaction chamber comprises tissue factor.

12. The test strip of claim 1 , wherein said assay and control reaction chambers comprise reagent compositions for measuring prothrombin time (PT).

13. The test strip of claim 1 , wherein the condition is determined as an electrical property of said sample.

14. The test strip of claim 1 wherein each of said reaction chambers comprises an electrode pair measuring a parameter of coagulation of sample in said reaction chamber.

Assignments (9)
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY RECORDED AT REEL 036994, FRAME 0192 AND REEL 037115, FRAME 0498 Recorded Oct 5, 2017
From: HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS COLLATERAL AGENT
To: ALERE CONNECT, LLC; ALERE SAN DIEGO, INC. (FKA BIOSITE INC. OR FKA CHOLESTECH CORP. OR FKA HEMOSENSE INC. OR FKA INVERNESS MEDICAL-BIOSTAR INC. OR FKA ISCHEMIA TECHNOLOGIES, INC. OR FKA TWISTDX, INC.); ALERE SCARBOROUGH, INC. (FKA MATRITECH, INC. FKA ADVANTAGE DIAGNOSTICS CORP. OR FKA BINAX, INC. OR FKA MILANO ACQUISITION CORP.); INNOVACON, INC. (FKA APPLIED BIOTECH, INC. OR FKA AMEDITECH INC.); IONIAN TECHNOLOGIES, LLC (FKA IONIAN TECHNOLOGIES, INC.); QUALITY ASSURED SERVICES INC. (FKA ZYCARE INC.); STANDING STONE, LLC; ESCREEN, INC.
Reel/Frame 044213/0258 →
ASSIGNMENT OF IP SECURITY AGREEMENT, PREVIOUSLY RECORDED AT REEL 036994, FRAME 0192 Recorded Nov 16, 2015
From: GENERAL ELECTRIC CAPITAL CORPORATION, AS RETIRING ADMINISTRATIVE AGENT
To: HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS SUCCESSOR ADMINISTRATIVE AGENT
Reel/Frame 037115/0498 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Oct 29, 2015
From: ALERE CONNECT, LLC; ALERE SAN DIEGO, INC. (FKA BIOSITE INC. OR FKA CHOLESTECH CORP. OR FKA HEMOSENSE INC. OR FKA INVERNESS MEDICAL-BIOSTAR INC. OR FKA ISCHEMIA TECHNOLOGIES, INC. OR FKA TWISTDX, INC.); ALERE SCARBOROUGH, INC. (FKA MATRITECH, INC. FKA ADVANTAGE DIAGNOSTICS CORP. OR FKA BINAX, INC. OR FKA MILANO ACQUISITION CORP.); INNOVACON, INC. (FKA APPLIED BIOTECH, INC. OR FKA AMEDITECH INC.); IONIAN TECHNOLOGIES, LLC (FKA IONIAN TECHNOLOGIES, INC.); QUALITY ASSURED SERVICES INC. (FKA ZYCARE INC.); STANDING STONE, LLC; ESCREEN, INC.
To: GENERAL ELECTRIC CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 036994/0192 →
NOTICE OF RELEASE OF SECURITY INTEREST IN PATENTS RECORDED AT REEL 026557 FRAME 0287 Recorded Jun 23, 2015
From: GENERAL ELECTRIC CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT AND COLLATERAL AGENT
To: ADVANTAGE DIAGNOSTICS CORPORATION; ALERE MEDICAL, INC.; ALERE SAN DIEGO, INC.; ALERE SCARBOROUGH, INC.; AMEDITECH INC.; APPLIED BIOTECH, INC.; BINAX, INC.; BIOSITE INCORPORATED; CHOLESTECH CORPORATION; GENECARE MEDICAL GENETICS CENTER, INC.; HEMOSENSE, INC.; INSTANT TECHNOLOGIES, INC.; INVERNESS MEDICAL - BIOSTAR INC.; ISCHEMIA TECHNOLOGIES, INC.; MATRITECH, INC.; MATRIA HEALTHCARE, INC.; ZYCARE, INC.
Reel/Frame 036011/0581 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2012
From: HEMOSENSE, INC
To: ALERE SAN DIEGO, INC
Reel/Frame 028349/0270 →
SECURITY AGREEMENT Recorded Jul 7, 2011
From: ADVANTAGE DIAGNOSTICS CORPORATION; ALERE MEDICAL INCORPORATED; ALERE SAN DIEGO, INC.; ALERE SCARBOROUGH, INC.; AMEDITECH INC.; APPLIED BIOTECH, INC.; BINAX, INC.; BIOSITE INCORPORATED; CHOLESTECH CORPORATION; GENECARE MEDICAL GENETICS CENTER, INC.; HEMOSENSE, INC.; INSTANT TECHNOLOGIES, INC.; INVERNESS MEDICAL - BIOSTAR INC.; ISCHEMIA TECHNOLOGIES, INC.; MATRITECH, INC.; ZYCARE INC.; MARTIA HEALTHCARE, INC.
To: GENERAL ELECTRIC CAPITAL CORPORATION
Reel/Frame 026557/0287 →
SECURITY AGREEMENT Recorded Dec 12, 2007
From: HEMOSENSE, INC.
To: GENERAL ELECTRIC CAPITAL CORPORATION, AS AGENT
Reel/Frame 020227/0892 →
SECURITY AGREEMENT Recorded Dec 10, 2007
From: HEMOSENSE, INC.
To: GENERAL ELECTRIC CAPITAL CORPORATION, AS AGENT
Reel/Frame 020218/0639 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 27, 2006
From: FARNAM, W. EDWARD, III; NAVARRO, MARIA C.
To: HEMOSENSE, INC.
Reel/Frame 018681/0128 →
Continuity (1)
Related Publication 20080124749A1 · May 29, 2008