Mesenchymal stem cells and uses therefor
Methods of treating autoimmune diseases, allergic responses, cancer, or inflammatory diseases in an animal, promoting would healing, repairing epithelial damage and promoting angiogenesis in an organ or tissue of an animal by administering to the animal mesenchymal stem cells in an effective amount.
1 . A method of promoting angiogenesis in an organ or tissue of an animal other than the heart, comprising:
administering to said animal mesenchymal stem cells in an amount effective to promote angiogenesis in an organ or tissue other than the heart of said animal.
2 . The method of claim 1 wherein said animal is a mammal.
3 . The method of claim 2 wherein said mammal is a primate.
4 . The method of claim 3 wherein said primate is a human.
5 . The method of claim 1 wherein said mesenchymal stem cells are administered in an amount of from about 1×10 5 cells/kg to about 1×10 7 cells/kg.
6 . The method of claim 5 wherein said mesenchymal stem cells are administered in an amount of from about 1×10 6 cells/kg to about 5×10 6 cells/kg.
7 . The method of claim 1 wherein said mesenchymal stem cells are administered systemically.
8 . The method of claim 1 wherein said mesenchymal stem cells are administered intravenously.
9 . The method of claim 1 wherein said mesenchymal stem cells are administered by direct injection to said organ or tissue other than the heart of said animal.
10 . A method of treating a disease selected from the group consisting of autoimmune diseases and graft-versus-host in an animal, comprising:
administering to said animal mesenchymal stem cells in an amount effective to treat said disease in said animal
11 . The method of claim 10 wherein said animal is a mammal
12 . The method of claim 11 wherein said mammal is a human.
13 . The method of claim 10 wherein said disease is multiple sclerosis.
14 . A method of treating an inflammatory response in an animal, comprising:
administering to said animal mesenchymal stem cells in an amount effective to treat said inflammatory response in said animal.
15 . The method of claim 14 wherein said animal is a mammal.
16 . The method of claim 15 wherein said mammal is a human.
17 . The method of claim 14 wherein said inflammatory response is associated with psoriasis.
18 . A method of treating cancer in an animal, comprising:
administering to said animal mesenchymal stem cells in an amount effective to treat cancer in said animal.
19 . The method of claim 18 wherein said animal is a mammal.
20 . The method of claim 19 wherein said mammal is a human.
21 . A method of treating an allergic disease or disorder in an animal, comprising:
administering to said animal mesenchymal stem cells in an amount effective to treat said allergic disease or disorder in said animal.
22 . The method of claim 21 wherein said animal is a mammal.
23 . The method of claim 22 wherein said mammal is a human.
24 . The method of claim 14 wherein said allergic disease or disorder is arthritis.
25 . A method of promoting wound healing in an animal, comprising:
administering to said animal mesenchymal stem cells in an amount effective to promote wound healing in said animal.
26 . The method of claim 25 wherein said animal is a mammal.
27 . The method of claim 26 wherein said mammal is a human.
28 . A method of preventing fibrosis in an animal, comprising:
administering to said animal mesenchymal stem cells in an amount effective to prevent fibrosis in said animal.
29 . A method of repairing epithelial damage in an animal, comprising:
administering to said animal mesenchymal stem cells in an amount effective to repair epithelial damage in said animal.
30 . The method of claim 29 wherein said animal is a mammal.
31 . The method of claim 30 wherein said mammal is a human.
32 . The method of claim 29 wherein said epithelial damage is a result of graft-versus-host disease.