Hetaryloxy-substituted phenylamino pyrimidines as Rho kinase inhibitors
View Patent ↗The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
1. A compound of the formula (I)
in which
R 1 represents chlorine, cyano, methyl, ethyl, hydroxyethyl, methoxyethyl or cyclopropyl,
R 2 represents hydrogen or fluorine, and
R 3 represents hydrogen, chlorine, trifluoromethyl or pentafluoroethyl, or a salt thereof.
2. The compound as claimed in claim 1 ,
in which
R 1 represents chlorine, cyano, methyl, ethyl, hydroxyethyl, methoxyethyl or cyclopropyl,
R 2 represents hydrogen or fluorine, and
R 3 represents hydrogen, chlorine or trifluoromethyl, or a salt thereof.
3. The compound as claimed in claim 1 ,
in which
R 1 represents cyano, methyl or hydroxyethyl,
R 2 represents hydrogen or fluorine, and
R 3 represents chlorine or trifluoromethyl,
or a salt thereof.
4. A process for preparing a compound of the formula (I) as defined in claim 1 , characterized in that
a compound of the formula (II)
in which
R 1 and R 2 are as defined in claim 1 is reacted with a compound of the formula (III)
in which
R 3 is as defined in claim 1 .
5. A method for the treatment of erectile dysfunction comprising administering an effective amount of a compound of the formula (I) as defined in claim 1 .
6. A method for the treatment of hypertension, comprising administering an effective amount of a compound of the formula (I) as defined in claim 1 .
7. A pharmaceutical composition, comprising a compound of the formula (I) as defined in claim 1 in combination with a further active compound.
8. A pharmaceutical composition comprising a compound of the formula (I) as defined in claim 1 in combination with an inert nontoxic pharmaceutically acceptable auxiliary.