Prevention and treatment of ocular side effects with a cyclosporin
View Patent ↗Presently described are methods of administration and associated treatment of one or more ocular conditions using cyclosporine, or an analog or derivative thereof. The ocular conditions can be a result of treatment using other therapeutic agents, such as chemotherapy agents, antiviral agents and immunomodulators.
1. A method comprising administering cyclosporin A to an eye of a mammal in combination with administration of docetaxel to said mammal, wherein said method is effective in treating keratoconjunctivitis or conjunctivitis.
2. A method comprising administering cyclosporin A to an eye of a mammal in combination with administration of docetaxel or fluorouracil to the mammal, wherein the method is effective to treat abnormal lacrimation, keratitis, keratoconjunctivitis, or conjunctivitis.
3. The method of claim 2 , wherein the method is effective to treat abnormal lacrimation.
4. The method of claim 2 , wherein the method is effective to treat keratitis.
5. The method of claim 2 , wherein the method is effective to treat keratoconjunctivitis.
6. The method of claim 2 , wherein the method is effective to treat conjunctivitis.
7. A method comprising the step of administering cyclosporin A to an eye of a mammal undergoing treatment with docetaxel or fluorouracil, wherein the method is effective to treat abnormal lacrimation, keratitis, keratoconjunctivitis, or conjunctivitis.
8. The method of claim 7 , wherein the method is effective to treat abnormal lacrimation.
9. The method of claim 7 , wherein the method is effective to treat keratitis.
10. The method of claim 7 , wherein the method is effective to treat keratoconjunctivitis.
11. The method of claim 7 , wherein the method is effective to treat conjunctivitis.