SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
1 - 71 . (canceled)
72 . A method of blocking signaling by PRO5798, the method comprising providing an antibody that binds amino acids 22-189 of SEQ ID NO:232 to an extracellular environment.
73 . The method of claim 72 , wherein the extracellular environment is an extracellular environment of a tumor.
74 . The method of claim 73 , wherein the tumor is a lung tumor.
75 . The method of claim 73 , wherein the tumor is a colon tumor.
76 . The method of claim 72 , wherein the antibody is a monoclonal antibody.
77 . The method of claim 72 , wherein the antibody is a human antibody.
78 . The method of claim 72 , wherein the antibody is a humanized antibody.
79 . The method of claim 72 , wherein the antibody is an antibody fragment.
80 . The method of claim 72 , wherein the antibody is a single chain antibody.
81 . A method of treating a tumor comprising exposing the tumor to an antibody that binds to amino acids 22-189 of SEQ ID NO:232.
82 . The method of claim 81 , wherein the tumor is a lung tumor.
83 . The method of claim 81 , wherein the tumor is a colon tumor.
84 . The method of claim 81 , wherein the antibody is a monoclonal antibody.
85 . The method of claim 81 , wherein the antibody is a human antibody.
86 . The method of claim 81 , wherein the antibody is a humanized antibody.
87 . The method of claim 81 , wherein the antibody is an antibody fragment.
88 . The method of claim 81 , wherein the antibody is a single chain antibody.